q ?N ?EZ?~?;?q ?97?? Annu. Rev. Immunol. 1985.3:501-539. Downloaded from www.annualreviews.org by SCELC Trial on 10/25/13. For personal use only.
)$ǞY wÔǞĠhhvƉÓǞçQP($ǞMǞ(×KM(Ǟ ċƊƍƽƚŵacƩǞƿǞKQPøǞŅƼǞ)kvĿǞY we ƷƦǞġkŊ$Ǟ)ǞƛeacƪrǞƜ r Ɲƶ őǞ
-
9 -)'!9 ')!%!-.9
)'*)((-9 )9 Annu. Rev. Immunol. 1985.3:501-539. Downloaded from www.annualreviews.org by SCELC Trial on 10/25/13. For personal use only.
*+)-!(9 (-!("!-.9 E6CT T "$:C/IT g ɖɖ!"3ɖ"ɖ"
ɖ''!ɖɖ!- ɖ-ɖ-Aɖ- ɖɖɖAɖ 'ɖ ,-Aɖ -ɖ !-7ɖ p-!ɖ Éɖ -"!3ɖ ɖ ɖ ɖ , ɖ-ɖ!"ɖ-ɖ! ɖAɖ-ɖĝB ɖ'ɖ- ɖɖ!-Pɖ Yɖ!,A,ģ ɖɖ-!ɖ!-ɖĝB ɖɖ A-ɖA! ɖ A !ɖ !-ɖ B! ɖ 'Aɖ !, ɖ !-ɖ ɖ !ɖ -ɖ A,7ɖ Yɖ 'Aɖ!-!ɖ-ɖ!-ɖ!ɖɖA!A!d'ɖɖɖA--ɖ -ɖ ɖ A! ɖ '!A-ɖ "ɖA!-A-Aɖ A,ɖ ,Aɖ ɖ ĕ[ɖ ³m3ɖ ±,-!AAɖ '- !Æ-3ɖ !,!'ɖ , !ɖ A!-A-3ɖ [-,!ɖA!-A-ɖ'ɖ'!-8BAɖ,'7ɖɖ'ɖ -ɖ¨8!ɖ'ɖ,!-ɖ'!A-ɖɖɖ! ɖɖ!- ,-ɖ ɖ ɖ!-'ɖAtAɖ-!-ɖ.ɖɖ-Aɖ!,!ɖA-!2ɖ-,ɖ ɖ±B ɖ-ɖ'', ɖ-ɖA'ɖ!',ɖ'ɖ!,A,! ɖ ɖ.-!ɖ !"3ɖɖ M2ɖ ɖ''-3ɖɖ -A-ɖ-ɖ-Aɖ--ɖɖ!-ɖɖ ɖA! ɖ'!A-ɖɖ!-''ɖ ɖ,ɖ-ɖɖA-,- ɖ ,'ɖ -ɖ ! ɖ --ɖ ɖ !-ɖ ɖ - A, !ɖ 'Aɖ .q?ąɖ q q27ɖ !
3ɖɖB! ɖ'ɖ ɖ!Ȟɖ ɖ-ɖ!-ɖ!ɑ ,!ɖA-!ɖ!ɖɖ!- ɖ!ɖ"ɖɖ-!A ɖA A, -ɖ . Z 923ɖ "Aɖ ,ɖ
ɖ - ɖ ɖ ,!ɖ -ɖ ɖ ,-ɖ 'ɖ -' ɖ!ɖ-!ɖɖŰɖɖɖA-8A-'ɖ!7ɖ "ɖ-ɖɖA,!!ɖ -ɖ-ɖ-!A ɖA A, -ɖɖ!e A
ɖ'!'ɖ-!-ɖ-,ɖɖ! ɖ- ɖ-ɖ'!ɖ-ɖ -!ɖɖɖ!-Ⱦɖɖɖ ɖ!-ɖ!'ɖA!-- A, !ɖ!,A,!ɖ ɖ B! ɖ ,, ɖ -!ɖ ,'!'ɖ ɖ 'Aɖ Aɖ -ɖ !-ɖ
;?Eɖ
7 *0? 7?
L PɖY Lɖ : ɖɖ
ɖ Lɖ'ɖɖ: ɖ:ɖ Ñ ɖ'ɖ ɖɖ ɖɖ`ɖ ɖ ĉǞ Qr=y>$>`ɖ`ɖŒɖɖ ' ɖAG ɖ'ɖɖ ɖ:'ɖɖ ɖ ɖťZ V2oɖF ɖ :ɖ: ɖ ɖ 'ɖ ɖ'::ɖɖɖ"è ɖ 'ɖ Lɖ ɖLɖ ɖ:L3ɖ ' : ɖ ɖ : ɖ Û : : ɖ : : ɖ ɖ' ɖ Lɖ .Z93ɖ ZE2Pɖ h ɖ :ɖ: ɖ
' ɖ : >ɖ ɖ >
ɖ .>ɖ ɖ ɖ >ɖ ' ɖ : 2ɖ :" ɖ : Lɖ ɖ ɖ : Lɖ :ɖ : ɖ LPɖ Ėɖ =ɖ `Lɖ ' ':ɖ : ɖ :ɖ : Lɖ'ɖ ɖLɖ : ɖ' Lɖ ɖ:ɖ " ɖɖ ɖɖ:ɖ :'ɖɖ ɖ:8'' ɖ ɖɖ ɖɖ: ɖ ɖ 'ɖɖɖ ' ɖ` ɖɖ :ɖɖ ɖ`Lɖ ɖ ɖ ɖ Ɖɖ Ľɖ ɖ ɖ ' ɖ B LɖL ɖɖ 'Lɖ L' ɖɖ Lɖɖ:ɖ Ćɖ"ɖ" ɖ L LɖLɖɖ ɖ38@G:'ɖ,85-Gɖɖɖ ɖ ɖ. ɖ :ɖ: L2ɖ :'ɖ" ''ɖ Lɖ."ɖ:ɖ L2=ɖ L Pɖ ®ɖ '' ɖ ɖ' ɖ : ɖ =ɖ ɖ ɖ ɖ :Åɖė ɖǠ Åɖ Åȹɖ Ǣ ÅɖÅɖ :ėɖǀî:ɖ :ÅÅúɖ
L ĈL: ɖ' L'ɖ ɖɖ L:3ɖɖ ɖɖ:L ɖ L3ɖ
ɖ :
3ɖ:'ɖɖ ɖ`ɖ ɖɖ`ɖ ɖ 'ǖ Pɖ h>3ɖ`ɖ' :ɖ ɖɖ ɖ ɖɖɖ ɖ ɖɖ
:'ɖɖ`Lɖ`ɖ ɖɖB: ɖɖɖɖɖ ɖ :ɖ : Lɖ ɖ ɖ Ǩ'ɖ Ⱥ ɖ L Lɖ :Ȼɖ :ɖ ɖ L'ɖ ''ɖ ɖ' ɖ L:ɖLLLɖ. Z ;2oɖ p:'ɖɖɖ : ɖɖ L ɖ L:ɖ ' : ɖ`'Lɖ:ɖ >ɖɖ`ɖ 3ɖ ɖɖÑɖB ɖ:ɖ ɖg>ɖ ɖ ɖ ɖ ɖPɖc`3ɖɖ : ɖ ɖ ɖ ɖ ɖ :ɖ : ɖ>ɖ''ɖ:'ɖ' ''ɖɖ ɖg"ɖ>ɖ`ɖrFɖ ' ɖ Lɖ B LLɖ ɖ :ɖ L ɖ :ȁɖ ɖ ɖ ɖ L ɖ ɖ rFɖ .Z2Pɖ Ʋɖ ɖ :ɖ Lɖ Lɖ Lɖ :ɖ ɖ äB ɖ Lɖ
:'ɖ ɖ ɖ rFɖ ' ɖ:'ɖ ɖ ɖ:L ɖ. Z N2PɖYɖ :ɖ ɖ`>ɖ>ɖ' ɖɖɖɖr8 ɖ 'ɖ:3ɖ`ɖ
Lɖ''ɖ ɖ?ɖL Lɖ:'ɖ' L''ɖ ɖZ Ɠ?ɖL Lɖɖɖ : ɖ : ɖ :L 'Pɖ Yɖ': ɖ ãB ɖ ɖ®Í3ɖ " ɖ :Lɖ ɖ ɖ Õ"ɖ ɖ ɖ ɖ:'ɖ`'' ɖ ' 3ɖ :ɖ ɖ ɖ' ɖ 'ɖ ɖ ɖ ' Pɖ z:ɖ ɖ ɖ :ɖ ɖ Ñɖ
ɖł3ɖĞɖłɖĽ:ɖ3ɖ'ɖɖ[ Ņkɖ?Vɖz:ɖ:ɖ' ɖ ɖ [ Ņkɖā Ȝ>Ăɖ: ɖ."ɖ`ɖ L:ɖ:'ɖ: :ɖ': L2ɖɖɖɖ ?ɕɖ.M2fɖrLɖɖ'::ɖ ' ɖ:L 'ɖãL ɖL LÛ ɖ. Z H2ɖ ' :ɖ:ɖɖB ɖ g'ɖ
ɖ': Lɖ:>ɖ `ɖ ' ɖ-Ñ :'ɖ> `ɖ' ɖɖÑɖ`ɖ: 'ɖ Pɖ ®ɖ: 3ɖ`ɖ : ɖõɖ 3ɖɖ" ɖ:ɖ ɖ ɖɖ
Annu. Rev. Immunol. 1985.3:501-539. Downloaded from www.annualreviews.org by SCELC Trial on 10/25/13. For personal use only.
:
Annu. Rev. Immunol. 1985.3:501-539. Downloaded from www.annualreviews.org by SCELC Trial on 10/25/13. For personal use only.
6,)? ),%6;? *? *6*6;?
;?;ɖ
ɖ >ɖ ®Íɖ >ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖɖ ɖ±B Pɖ ɖ ɖɖ =ɖ ɖ
ɖɖBɖ ɖɖ doɖcɖ>ɖ ɖ ɖ > ɖ ɖ zɖ ɖ ɖ ɖ z ɖ ɖ ɖ ɖ
ɖ ɖɖ ɖ ɖɖ RM=ɖ9?Pɖ cɖ ɖ B ɖ ɖ ɖ ®Íɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ g ɖ ɖ Pɖ ɖ ɖ ɖ ɖ ɖ ɖ B Éɖ ɖ g ɖ ɖ> ɖ ɖɖɖ=ɖɖ ɖ ãB ɖ ɖ ɖ ɖ ɖ ɖ ɖ g ɖ jɖ zB ɖ >ɖ ɖɖɖ>ɖɖɖ ɖɖɖ =ɖ ɖ ɖ ɖɖɖ ɖ ɖ9RjɖzɖBɖ ɖ Bg ɖÙɖ ɖɖ ɖ ɖɖ>ɖ ɖɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ 99Pɖ [ ɖ > ɖ ɖ ɖ ɖ ɖ ɖ >ɖ Pɖ cɖ ɖ ɖɖ B ɖɖ ɖ ɖɖɖ ɖ ɖ ɖ 9VPɖ ®ɖ ɖ g ɖ ɖ ɖ ɖ ɖ e ɖd8ɖ ɖ ɖ¥ɖ ɖ ɖɖ ɖ ɖ ɖ ɖ 9RPɖ ®ɖ ɖ ɖ ɖ ɖ Bɖɖɖɖ ɖè ɖá ɖ ɖɖɖɖ>ɖɖ
ɖ ɖ ɖɖ¨8ɖ ɖ9EPɖɖ=ɖ ɖɖd8ɖ
ɖ ɖɖ ɖ ɖ ɖ ɖ>ɖɖɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ 9;~9Myɖ h>=ɖ ɖ ɖ
ɖ ɖ°ɖɖ ƊɖɖB ɖ ɖ ɖè ɖɖdīɖɖ ɖ ɖ> ɖɖɖoɖ kè=ɖɖdīɖ ɖ ɖ ɖ ɖ ɖ ɖɖ ɖ ɖ ɖɖ ɖ ǩ ɖ ɖ ɖ?đɖ cɖɖ >ɖ ɖ ɖ ɖ° ɖ ¨ɖ ɖ ɖ > ɖ g>ɖɖ ɖɖɖɖB ɖ ɖɖɖɖ B ɖ ɖ ɖ ɖ ɖ ɖ Pɖ k d ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ 9?ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ± ɖȐ ɖ ɖ ° =ɖ ɖ ɖ¨8ɖ ȼɖR=ɖ9Pɖcɖɖ ɖ>ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ ɖ > ɖ ɖɖ ɖɖɖ ɖ ɖɖ ɖ> ɖɖ ɖ ɖ oɖ cɖ ɖ ɖ ɖɖ ɖ >ɖ B ɖ ɖ > ɖ ɖ ɖ ɖ ɖ ɖ 8 ɖ ɖ g ɖ Pɖ c ɖ ɖ ɖ ɖ ɖ ɖ ɖ >ɖ ɖ ɖ ɖ ɖ ɖ >ɖ Pɖ FɖB ɖ ɖɖ>ɖ ɖɖ=ɖɖɖ >=ɖ ɖ > ɖ ɖ >ɖ ɖ ɖ ɖ ɖ ɖ >ɖ ŏ ɖ ɖ ɖɖ ɖ jɖƼɖ ɖ ɖ ɖɖɖ ɖɖ ɖ ɖɖɖɖ d ɖɖɖ >ɖ ɖɖ ɖɖ ɖɖ č ɖɖ Ìɖ
Annu. Rev. Immunol. 1985.3:501-539. Downloaded from www.annualreviews.org by SCELC Trial on 10/25/13. For personal use only.
;?Dɖ
6 +0? 6=,? - 603,*? 6? %?
F!ɖ!ɖ¸ɖ ! ɖ'ɖɖ ɖ!3ɖɖ!ɖ8 ɖ ɖ!!ɖ !ɖ!ɖɖ!Ĝ ɖɖB 'ɖ! ɖɖ ɖ '!ɖ !ɖ ɖ ɖ !ɖ ! ɖ 'ɖ ɖ ɖ !ɖ ɖ !!ɖ!ɖ'! ɖ! ` ɖ! yɖɖɖɖ ɖ !ɖ
ɖ 'ɖ "ɖ ! ɖ !· 3ɖ 'ɖ ! Û B'ɖ!ɖ ɖ`ɖ !'!ɖɖ ɖɖ!ɖ!ɖ
fɖ F ɖɖɖ! ɖɖ ɖ ɖɖɖ ɖɖɖ ɖ !ɖ ɖ ɖ !'ɖ "ɖ ɖ !ɖ ɖ ! jɖ cɖ !"ɖ 'ɖ (G ɖ ' !ɖ ɖ '! ɖ B! ɖ "!gɖ ɖ ɖ !ɖ !!ɖ [h!ɖ ɖ "ɖ ''ɖ ɖ ɖ ɖ !'!'ɖ Ȥ ɖɖ'ɖɖ`d'ɖ'ɖ'ɖE g!! ɖ'ɖ ɖɖ!ɖɖ!ɖ" `ɖ ɖ! ɖ!'ɖ e ɖ'ɖ'ɖ`ɖ! ɖɖ``ñ! ɖ !
!Pɖļ`ɖɖ`ɖ ! ɖ ɖ !ɖ ɖ ɖ ' ɖ !ɖ !ɖ !ɖ ɖ !ɖ ɖɖɖ ɖɖ!ɖ Pɖ
7A:/+6+}ɚ fɚ388}ɚ @ôɚ ( ɚ A Iė OmǦ8>ɚ =ɚ W> ƽɚ v8>ɚ äɚ =\ >ɚ.ėÓėÚ ė t 5ė? ė ė ,ġ`& Û ɚ (Ìɚ kȷ¼&ɚ ɚ ė ±Sɚm8 ɚW \%IJɚ =ɚWɚ >\ɗ \ ɚ Eė mė Vė ? 5 ė ė ė HC8S}ɚ H }ɚ Sm}ɚ ± ɚ ?ɚ Õè>ëʼnèɚP#ɚkʼnȱÕ>ɚÀɚėǜȗ8ɚ /¼/ɚ `Tɚ `1ɚ Ȉ1`ɚ 1ɚ WE à ɚ(Ó1ɚ `Tɚ`Óɚ /ɚ `ɕ ?ɚ8 >ɚ ɚ5? ɚW% ɚ%mWɘ > ɚ S5 ɚ )Qþ+ė ė hėu ^ė ė O5mɚ WDǞ ¥!Iė .ė ( +)ė ! 5ė!ė !Iė ¥`DE``Ȝ&ɚĀ ɚ*À}ɚk1&ɚĀ ż] ɚ !ė
`ɚ `D11ɚ`TɚÓ1ɚ1/ɚɚ/E1/ɚ dȹ8ɚm>Ěƒ%WSɚä ɚTė ùóėGė ^ė
5 ? ė
(%m8 \Œ WSɚ >\ >ɚ =ɚSɚ m8 ɚ WWə >ɚd Ȧm>őm8 ɚ UQÿė^ ė¬? ė ?ė M8%ėɚ ( ɚ *Ǟ 3S8W>>Ųɚ Ħ¾Ǟ &ɚ ME1`ðɚ ɚĀ/ŭɚ Ffėkïɚ( ɚ ė [%ɚ > ɚ? %\>ɚɚ ė Y >\ ɚ >SC ɚ Sɚ %Œ >ɚ C S ɚ ɚ 5Cɚ >\5\>Ìɚ
"ė
UQ ė ? ·ė ?ė
ĩÓ`&ɚ( ɚ.E:ǞME1`&ɚ_ ďɚ¥EE1`ðɚH ɚ 3ɚ A Cė H\Ŏɚ dɚ 8ɚ DIɚ >\ɚ? \>ɚUij ÿǞ Rɚ? %\>ɚW% ɚɚ Aė Y>\ ɚ Tė Bėúìė 5ė? ė Iė ġI`&ɚ FCė pÀ)ɚ H #ɚ ÿ . ɚ *Ǟ ^ė Hɚȉx15Ĉ1mɚ`ǾɚĈ``Dɖ Ó1 ɚH%\\ɚ=ɚSɚ¥\8ɚ( 5mɚ \ɚ kɚ i88\5\ ɚ Ǖɚ
Iė
7 +) ËI 5 ? ė
;V?ɖ
7#-1^ 79/^ 0712/-^ 7^ )^
K"ɚ 3&ɚǗ ɚ ,&ɚO6T &ɚ@ &ɚ] 5 &ɚ *&ɚ[&ɚP K"27 ɚGė K'' ¤ ;Y2ɚ ;' ɚ p &ɚ X ɚ M ɚ !"+! ɚ ($ė -ė
Annu. Rev. Immunol. 1985.3:501-539. Downloaded from www.annualreviews.org by SCELC Trial on 10/25/13. For personal use only.
*17ė ė *$ė |$ė _Ĕ ėSeė K$4qė-Kė iɚ ɚ
;K ɚ *U &ɚ @ɚ Q ɚ K"+ K ɚ Rɚ ɚ ɚ xɚ Tɚ 6ɚ ɚ iɚ EKeÛ@ėė($@ė @$1qė ɚ3ɚM ɚ X&ɚ@ ɚR ɚp&ɚ ɚ,ɚ*0 &ɚ ɚ !7+ ɚCɚÆ < ¤ɚXUɚ ;; ɚ Mtɚ P ɚ Q ɚ @ Øɚ Q6§tɚ R ɚ Xɚ K"2+ ɚ q ~6 ɚ T 6ɚ ɚUɚɚx2ė =2Lė L ü ɚ tė K+ ɚ P-ɚ _ &ɚ O,-ɚ ( -ɚ P -ɚ k ɚ !"27 ɚ Oɚ Tɚ ɚ ɚ ɚ ɚ ɚ ɚ ɚ D ɚ Ĵ¦åɚ ^ɚ ëɚ Dȏɚ ¦åɚ ɚ ȫDɚ M[Riř ɚ ɚ xdLo)Rė 0>2Nė =ZLė L ɚ!B"ɚ !" ɚ 3D-ɚ i ɚ Ośɚ OD-ɚ 3 ɚ , -ɚ
;V;ɖ
P-ɚ * ɚ @ ɚ [ ɚ K"2Y¢ɚ [Ōɚ Ȋ| ɚ ɚ ɚ ^ɚ ɚ | ɚ ɚ^ɚɚJĘV ɚ ɚ ɚ Tɚ^ɚ D ɚ (>2ė Vė 02ė `&a&ė w ! " ²ė Y'Bɚ K 7' ɚ (-ɚ ( -ɚ OŜɚ O -ɚ _