1 3 5 7 9 11 13 15 17 19 21 X 2 4 6 8 10 12 14 16 18 20 22 1 3 ... - PLOS

Figure S1. Manhattan Plots and accompanying QQ Plots for seven RBC Traits in 12,502 HCHS/SOL Hispanic/Latinos.

Observed –log 10 p-value 4 6 8

14 12 -log 10(p-value) 6 8 10

2

4

0

2



0



10

Fig S1a. Hematocrit

Chromosome:

1

3 2

5 4

7 6

9 8

11 10

13 12

0

15

17 19 21 X 16 18 20 22

14

2 4 6 expected –log 10 p-value

8



Fig S1b. Hemoglobin



-23

6.0x10

0

5

-log10(p-value)

Observed –log10 p-value 10 15 20



Chromosome:

1

3 2

5 4

7 6

9 8

11 10

13 12

15 14

17 19 21 X 16 18 20 22

0

2 4 6 expected –log 10 p-value

8



Fig S1c. Red Blood Cell Count





2.8x10-33

1.4x10-19



0

5

-log10(p-value)

Observed –log 10 p-value 10 15 20 25 30

3.6x10-17

Chromosome:

1

3

5

2

7

4

9

6

11

8

10

13 12

15 14

0

17 19 21 X 16 18 20 22

2 4 6 expected –log 10 p-value

8





Fig S1d. Red Cell Distribution Width 3.7x10-29

0

5

-log10(p-value)

Observed –log 10 p-value 10 15 20 25

2.9x10-20

Chromosome:

1

3 2

5 4

7 6

9 8

11 10

13 12

15 14

17 19 21 X 16 18 20 22

0

2 4 6 expected –log 10 p-value

8





Fig S1e. Mean Corpuscular Hemoglobin



2.5x10-79

0

-log10(p-value)

Observed –log 10 p-value 20 40 60

1.0x10-34

80



Chromosome:

1

3 2

5 4

7 6

9

11

8

10

13 12

15 17 19 21 X 14 16 18 20 22

0

2 4 6 expected –log 10 p-value



8





Fig S1f. Mean Corpuscular Hemoglobin Concentration

7.0x10-17

0

5

-log10(p-value)

Observed –log 10 p-value 10 15 20

1.6x10-22

Chromosome:

1

3 2

5 4

7 6

9 8

11 10

13 12

15 14

17 16

19 21 X 18 20 22

0

2 4 6 expected –log 10 p-value

8



Fig S1g. Mean Corpuscular Volume





1.6x10-17

2.3x10-17



10

-log10(p-value)

Observed –log 10 p-value 20 30 40 50

3.9x10-56

0

Chromosome:



1

3 2

5 4

7 6

9 8

11 10

13 12

15 14

17 19 21 X 16 18 20 22

0

2 4 6 expected –log 10 p-value

8