Cancer Medicine
Open Access
ORIGINAL RESEARCH
Elevated glypican-1 expression is associated with an unfavorable prognosis in pancreatic ductal adenocarcinoma Haizhen Lu1,a, Fangfei Niu2,a, Fang Liu2, Jiajia Gao2, Yulin Sun2 & Xiaohang Zhao2 1Department
of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100021, China 2State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China
Keywords Biomarker, gene expression, glypican-1, pancreatic ductal adenocarcinoma, prognostic factor Correspondence Xiaohang Zhao and Yulin Sun, State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, 17 Panjiayuan Nanli, Chaoyang, Beijing 100021, China. Tel: +86 10 67709015(XZ), +86 10 87788423(YS); Fax: +86 10 87778360, E-mails:
[email protected], ylsun@cicams. ac.cn Funding Information This work was supported by grants from the National Natural Science Foundation (81572840, 81572365, 81372591 and 91629105), the State Key Project for Basic Research (2014CBA02001 and 2014CBA02002) of China and the CAMS Innovation Fund for Medical Sciences (2016-I2M-1-001).
Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer in humans, with a 5- year survival rate of
