724 Angina pectoris stable

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Oct 19, 2015 - enhanced coronary reactivity in patients with vasospastic angina ... to exhibit circadian variation in the occurrence of angina attacks with a peak ...
724

Angina pectoris stable

P4008 | BEDSIDE Short term physical exercise leads to a small troponin increase measurable with a high-sensitive cardiac troponin I assay T. Reichlin, S.M. Sou, T.H. Hochgruber, E. Vogler, K. Roost, M. Zellweger, S. Osswald, C. Mueller. University Hospital Basel, Basel, Switzerland

Circadian change of Rho-kinase activity

important role of Rho-kinase activity in the circadian variation of ischemic events of VSA patients.

P4010 | BEDSIDE The correlation of visual and quantitative assessment for regional LV function in Dobutamine Stress Echocardiography (DSE) by Speckle Tracking (STE) and Automated Function Imaging (AFI) K. Wierzbowska-Drabik, N. Roszczyk, M. Plewka, J.Z. Peruga, J.D. Kasprzak. Medical University, Lodz, Poland

Figure 1

Conclusions: Short term exercise with achievement of heart rates >85% of the maximum predicted heart rate leads to a small, but measurable, progressive and signficant increase in hs-cTnI regardless of presence or absence of underlying ischemia.

Background: Parameters of longitudinal deformation derived from STE showed diagnostic value for differentiation among assessed visually resting contractility impairment. There is still a little data concerning relationships between visual and quantitative contractility evaluation during peak stage of stress echocardiography. Aim: We aimed to assess the relationship between myocardial contractility stratified visually as normo- hipo- and akinesis and longitudinal strain (S) and strain rate (SR) in both stages of DSE- at baseline (0) and at peak stress (1). Methods: We examined by DSE 238 patients, 105 female, mean age 62±9. The whole group had evaluated the status of the coronary arteries by angiography or computed tomography. Mean heart rate at baseline was 66±10 beat/minute and at peak 140±12 beat/minute. In all segments of LV systolic longitudinal strain - SLS (both by STE and AFI) and systolic longitudinal strain rate - SLSR was measured. Results: We compared deformation parameters among segments assessed as normokinetic, hipokinetic and akinetic during baseline and peak stage of DSE and observed decreasing absolute values of SLS and SLSR along with deepening contractility impairment. The results are displayed in table. The comparison of deformation parameters Parameter SLS0 SLSR0 AFI0 Parameter

P4009 | BEDSIDE Circadian variation of rho-kinase activity associated with enhanced coronary reactivity in patients with vasospastic angina T. Nihei, J. Takahashi, Y. Kikuchi, R. Tsuburaya, T. Shiroto, Y. Ito, Y. Matsumoto, M. Nakayama, K. Ito, H. Shimokawa. Tohoku University Graduate School of Medicine, Department of Cardiovascular Medicine, Sendai, Japan Background: We have recently demonstrated that Rho-kinase activity in circulating neutrophils is a useful biomarker for vasospastic angina (VSA). VSA is known to exhibit circadian variation in the occurrence of angina attacks with a peak in the early morning. We examined whether Rho-kinase activity in circulating neutrophils also exhibits circadian variation and could reflect coronary artery tone and vasomotor reactivity. Methods: In 25 consecutive VSA patients with proven coronary spasm (M/F 17/8, 59±11 [SD] yrs) and 17 controls (M/F 11/6, 58±16 yrs), we measured Rho-kinase activity in circulating neutrophils (as expressed in the ratio of phosphorylated/total form of myosin binding subunit, a Rho-kinase substrate) at 21:00, 6:00, 12:00. We also examined the relationship between Rho-kinase activity at spasm provocation test performed in the morning and coronary vasodilating responses to intracoronary nitrate. Results: Rho-kinase activity was significantly higher in VSA patients than in controls at 6:00 (1.24±0.18 vs. 0.95±0.18, P