a, -b, -g - PLOS

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Wi-38. CON(PRE). Wi-38. 4d post 10 Gy XRA. Wi-38. 4d post 0.5 Gy XRA. Wi-38. 10d post 0.5 Gy XRA. Wi-38 GSE. 4d post 10 Gy XRA. Wi-38. 4d post RAS.
B

WI-38 p53 status XRA dose (Gy)

wt

wt

wt

GSE

+

+

+

-

C

0

0.5

10

10

n/a

2 4 7 10

2 4 7 10

2 4 7 10

Wi-38 Wi-38 Wi-38 Wi-38 Wi-38 GSE Wi-38 Wi-38 Wi-38 GSE Wi-38

SE N

(R SE EP; XR N (R A) AS SE ) N (G SE SE > R N EP (G ;X SE R R A) > EV R AS )

A

+

+

-

+

-

+

-

+

Secretory profile extent

41

49

56

61

36

Profile comparison vs SEN (REP;XRA)

p53 status RAS status

Overall conserved

-

32

39

35

21

(78 %)

(95 %)

(85 %)

(51 %)

Overall conserved & further increased

17

24

24

(41 %)

(59 %)

(59 %)

(22 %)

9

Uniquely increased

17

17

26

15

Days after irradiation IL-6 GRO (-a, -b, -g) IL-8 GM-CSF IL-7 GRO-a ICAM-1 Osteopro tegerin HGF IGFBP-4 MCP-2 uPARProliferation IGFBP-2 BrdU labelling Eotaxin-3

0

1

Correlation

+

+

-

-

> 80%

> 80%

< 5%

< 5%

CON (PRE) 4d post 10 Gy 4d post 0.5 Gy 10d post 0.5 Gy 4d post 10 Gy 4d post RAS 10d post 10 Gy 10d post 10 Gy 10d post RAS

XRA XRA XRA XRA XRA XRA