A Comprehensive, High-Resolution Genomic ... - Genome Research

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LETTER

A Comprehensive, High-Resolution Genomic Transcript Map of Human Skeletal Muscle Stefania Bortoluzzi,1 Luca Rampoldi,1 Barbara Simionati,2 Rosanna Zimbello,2 Alessandro Barbon,1 Fabio d’Alessi,1 Natascia Tiso,1 Alberto Pallavicini,1 Stefano Toppo,2 Nicola Cannata,2 Giorgio Valle,2 Gerolamo Lanfranchi,2 and Gian Antonio Danieli1,3 1

Department of Biology and 2CRIBI Biotechnology Center, University of Padua, Padua, Italy

We present the Human Muscle Gene Map (HMGM), the first comprehensive and updated high-resolution expression map of human skeletal muscle. The 1078 entries of the map were obtained by merging data retrieved from UniGene with the RH mapping information on 46 novel muscle transcripts, which showed no similarity to any known sequence. In the map, distances are expressed in megabase pairs. About one-quarter of the map entries represents putative novel genes. Genes known to be specifically expressed in muscle account for