A Fig. S1 B - PLOS

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ZMA 110 DAECLSFAVSLAKAASEIKATDIRVLCVRRLV-------- YWTRFFIILTAFSNAQ-IDAISSK---. CJE 1. ---MQERIDLIVKILDEKKAENIKTI DMSEQE--.
A SYN 24 BHA 1 ECO 1 CVI 1 SPN 1 ZMA 110 CJE 1 HSA 87 TPA 1 SCE 98 Cons

Fig. S1 APATEHLVWTIAQAAEERKAGDLVILKVTDVS--------YLADYFVICTGFSRTQ-VRAIADN----------------MSNQELLQLAVNAVDDKKAEQVVALNMKGIS--------LIADFFLICHGNSEKQ-VQAIAHE----------------MQGKALQDFVIDKIDDLKGQDIIALDVQGKS--------SITDCMIICTGTSSRH-VMSIADH---------------MQGKALQDFVIDKIDDLKGQDIIALDVQGKS SITDCMIICTGTSSRH VMSIADH -MEIQEISKLAIEALEDIKGKDIIELDTSKLT--------SLFQRMIVATGDSNRQ-VKALANS----------------MNEKELLELVVKAADEKRAEDILALDVQDLT--------SVTDYLVITSSMNSRQ-LDAIAAN---------------DAECLSFAVSLAKAASEIKATDIRVLCVRRLV--------YWTRFFIILTAFSNAQ-IDAISSK------------------MQERIDLIVKILDEKKAENIKTIDMSEQE--------YFVKYVIIAATLGERH-ALSLIDE---------------HTGPKFDIDMMVSLLRQENARDICVIQVPPEM--------RYTDYFVIVSGTSTRH-LHAMAFY----------------MSANGAASAVAEALCDARAEDVCVFDVSARC--------GWADFAVVATVPGLLHGTHRLVCE---------------KTSPNSLRKIADLLTGKLGLDDFLVFDLRKKSPNSVSAVNKLGDFMVICTARSTKHCHKSFLELNKFLKHEFCSSAYVEG . :. : :: . : :

SYN --------------IEKQ--VELVHGQLPTHTEGNSESIWVLQD--FGDVLVHTFMPEEREFYKLEAFWGHAQEQTLADIATAIGVAYNAPTSP BHA --------------LKK---VAQEQGIEIKRLEGYEQARWVLID--LGDVVVHVFHKDERAYYNLEKLWGDAPTVELEGVIS-----------ECO --------------VVQ---ESRAAGLLPLGVEGENSADWIVVD--LGDVIVHVMQEESRRLYELEKLWS-----------------------CVI --------------VQV---KLKEAGVDIVGSEGHESGEWVLVD--AGDVVVHVMLPAVRDYYDIEALWGGQKPSFAVGAAKPWSAV------SPN --------------IRE---KVAQAGFKGSHVEGDAAGGWVLLD--LGAVVVHIFSEEMRAHYNLEKLWHEANSVDISEALA-----------ZMA --------------MRD----IGEKQFSKVASGDTKPNSWTLLD--FGDVVVHIFLPQQRAFYNLEEFYGNATPIELPFDTQRQ---------CJE --------------LKT---RLKAKGEEFLNIDSSEE--WSVID--LGDILIHLLTPEHRGIYNIEELLENLKKGRV----------------HSA --------------VVKMYKHLKCKRDPHVKIEGKDTDDWLCVD--FGSMVIHLMLPETREIYELEKLWTLRSYDDQLAQIAPETVPEDFILGI TPA --------------QAAR----FGLREVHRKKRGLCEEQWRVLD--FGSILVHLMSAQARAFYDLDRLWQDCLVAR-----------------SCE NFNERQESRRKRRLARKSNLSKLLGRSSECSAKDLNSEAWYMIDCRVDGIFVNILTQRRRNELNLEELYAPENEKSKFQNIDSGNVPTISGVNE Cons . * * . :.:: : * .:: :

B SYN ZMA TPA ECO CVI CJE SPN BHA SCE HSA Cons

1 1 1 1 1 1 1 1 1 1

----------------MIQQQTYLNVADNSGARKLMCLRVLG---TGNCTYGGIGDQIIAVVKDALPNMP---------------------MIQPQTLLNVADNSGARKLMCIRVIGA--AGNQRYARIGDVIIAVIKDAVPQMP---------------------MIQVQSRLNVADNSGARLVQCIKVVG---GSRRRYASVGDIIVVAVKDALPTSV---------------------MIQEQTMLNVADNSGARRVMCIKVLG---GSHRRYAGVGDIIKITIKEAIPRGK---------------------MIQMQTMLEVADNTGARHVQCIKVLG---GSKRRYASVGDIIKVSIKDAAPRGR---------------------MIQSFTRLAVADNSGAKELMCIKVLG---GSKRRYATVGDVIVASVKKALPNGK---------------------MIQTETRLKVADNSGAREILTIKVLG---GSGRKFANIGDVIVASVKQATPGGA---------------------MIQQESRLKVADNSGARELLCIKVLG---GSGRKTANIGDVIVCSVKQATPGGV---------------------MIFLKSVIKVIDNSGAQLAECIKVIRK--GSPKSPAMVGDRIVCVIQKAKPLTQNITGTA MAFFTGLWGPFTCVSRVLSHHCFSTTGSLSAIQKMTRVRVVDNSALGNSPYHRAPRCIHVYKKNGVGKVG-----D :: . . :. : ::*: . * :..

SYN ZMA TPA ECO CVI CJE SPN BHA SCE HSA Cons

----IKKSDVVRAVIVRTKQ-PLRRASGMSIRFDDNAAVIINAEGN-PRGTRVFG---PVARELRDKNFTKIVSLAPEVL ----LERSEVIRAVIVRTRK-EFKGDDGIIIRYDDNAAVIIDQKGN-PKGTRVFG---AVAEELRELNLTKIVSLAPEVL ----IKKGSVEKAVIVRVSK-EYRRVDGTYIRFDDNACVVIDANGN-PKGKRIFG---PVARELRDMDFTKIVSLAPEVL IKKGSVEKAVIVRVSK EYRRVDGTYIRFDDNACVVIDANGN PKGKRIFG PVARELRDMDFTKIVSLAPEVL ----VKKGDVLKAVVVRTKK-GVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIFG---PVTRELRSEKFMKIISLAPEVL ----VKKGDVYNAVVVRTAK-GVRRPDGSLIKFDSNAAVLLNNKLE-PIGTRIFG---PVTRELRTERFMKIVSLAPEVL ----VKKGQVVKAVIVRTKK-EIHRDNGSLIRFDENAAVILDNKRE-PIGTRIFG---PVGREVRYGGFMKIVSLAPEVL ----VKKGDVVKAVIVRTKS-GARRADGSYIKFDENAAVIIREDKT-PRGTRIFG---PVARELREGGFMKIVSLAPEVL ----VKKGDVVKAVIVRSKS-GVRRNDGSYIKFDENAAVIVRDDKS-PRGTRIFG---PVARELRDNQFMKIVSLAPEVL NTNRVKKGDICHAIVVRSKQRNMCRKDGSTVAFGDTACVLINKNTGEPLGTRIMANDGCVDRTLKDKGYNKICSLASRVI QILLAIKGQKKKALIVGHCMPGPRMTP----RFDSNNVVLIEDNGN-PVGTRIKTP-IPTSLRKREGEYSKVLAIAQNFV :.. .*::* :. . *:: . * *.*: . : *: ::* ..:

122 123 122 123 122 122 122 122 138 144

154 117 105 122 117 228 108 219…234 111 271…612