May 20, 2016 - standard pre-ESRD multidisciplinary care for patients with stage ... medical control according to the NKF KDOQI guidelines4,8,9. ..... The protective effects of proteinuria reduction persisted in late stage of CKD26,28,36,37.
www.nature.com/scientificreports
OPEN
received: 14 August 2015 accepted: 04 May 2016 Published: 20 May 2016
Proteinuria as a Therapeutic Target in Advanced Chronic Kidney Disease: a Retrospective Multicenter Cohort Study Chang-Hsu Chen1, Hon-Yen Wu2, Chieh-Li Wang3, Feng-Jung Yang4, Pei-Chen Wu5, Szu-Chun Hung6, Wei-Chih Kan7, Chung-Wei Yang8, Chih-Kang Chiang3, Jenq-Wen Huang3 & Kuan-Yu Hung3 Current evidence of proteinuria reduction as a surrogate target in advanced chronic kidney disease (CKD) is incomplete due to lack of patient-pooled database. We retrospectively studied a multicenter cohort of 1891 patients who were enrolled in the nationwide multidisciplinary pre-end stage renal disease care program with a baseline glomerular filtration rate (GFR) 1.04 g/g (n = 892)
