Apr 20, 2014 - ORIGINAL PAPER. A sensitive amperometric detection of dopamine agonist drug pramipexole at functionalized multi-walled carbon nanotubes.
Ionics (2014) 20:1599–1606 DOI 10.1007/s11581-014-1123-2
ORIGINAL PAPER
A sensitive amperometric detection of dopamine agonist drug pramipexole at functionalized multi-walled carbon nanotubes (f-MWCNTs) modified electrode Srikanth Cheemalapati & Chelladurai Karuppiah & Shen-Ming Chen
Received: 19 February 2014 / Revised: 24 March 2014 / Accepted: 3 April 2014 / Published online: 20 April 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract The electrochemical detection of dopaminergic agonist drug pramipexole dihydrochloride monohydrate (PPX) has been investigated by cyclic voltammetric (CV) and amperometric i–t techniques at functionalized multi-walled carbon nanotubes-modified glassy carbon electrode. For the first time, a sensitive and rapid electrochemical method was developed for the determination of PPX. The surface morphological characteristics of the proposed electrode have been studied by using transmission electron microscopy (TEM); further, electrochemical impedance spectroscopy (EIS) and Fourier transform infrared spectroscopy (FTIR) have been employed. PPX shows an irreversible anodic peak, which may be ascribed to the oxidation of the –NH groups of PPX. The proposed method was showing good sensitivity of 0.993 μA μM−1 cm−2 with a linear range of 5 to 340 μM by amperometric i–t and CV technique shows a linear range of 12.5 to 313 μM with a sensitivity of 1.92 μA μM−1 cm−2. The recovery of PPX from blood serum samples was found 100.6 and 98.9 %, respectively. Furthermore, the proposed method has been demonstrated for the determination of PPX in commercially available pharmaceutical samples and good agreement of results obtained.
Keywords Functionalized multi-walled carbon nanotubes . Modified electrode . Amperometry . Pramipexole Electronic supplementary material The online version of this article (doi:10.1007/s11581-014-1123-2) contains supplementary material, which is available to authorized users. S. Cheemalapati : C. Karuppiah : S.
