A Short Comprehensive and Imperative Note on

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7 days ago - Pharmacology is the science of drugs and study of mechanism of action of drugs and lead compounds on the targets or target proteins or ...
 

A Short Comprehensive and Imperative Note on Regenerative Pharmacology Devansh Mehta1*, Parkhi Rastogi2, Mohd Shuaib1, Mohd Ali3 ’ƒ”–‹…—Žƒ” –Š‡”ƒ’›‘”–Š‡”ƒ’‡—–‹…• ƒ’’Ž‹‡† ‹ ‘”†‡”–‘ˆ‹† –Š‡ǡDz‹‰Š– …—”‡ˆ‘”–Š‡ ‹‰Š–†‹•‡ƒ•‡dzǤ ȏʹȐ ‡‰‡‡”ƒ–‹˜‡’Šƒ”ƒ…‘Ž‘‰›ƒ•‹–Šƒ•„‡‡‡™Ž›…‘‹‡† …ƒ Š‡Ž’ ‹ „”‹‰‹‰ ”‡˜‘Ž—–‹‘ ‹ –Š‡ Š‡ƒŽ–Š…ƒ”‡ ƒ† ’Šƒ”ƒ…‡—–‹…ƒŽ ‹†—•–”›Ǥ • –ƒ‡ ˆ‘” ‡Ǥ‰Ǥ  ‘”†‡” –‘ ˆ‹† …—”‡ˆ‘”ƒ„”ƒ‹†‹•‘”†‡”ǡ•—…Šƒ•ǡŽœŠ‡‹‡”ǯ•†‹•‡ƒ•‡ǡ–Š‡ ”‡…‡’–‘” ’”‡•‡– ‹ –Š‡ …‘”‡” ‘ˆ –Š‡ „”ƒ‹ǡ …‘—Ž† „‡ ”‡’ƒ‹”‡† ‘” ”‡…‘•–”—…–‡† ‹ ‘”†‡” –‘ „”‹‰ ”‡•—Ž–• ’‘•‹–‹˜‡Ž›™‹–Š–Š‡‡™Ž›‹–”‘†—…‡††”—‰‘Ž‡…—Ž‡ǤŠ‹• ™ƒ›ǡ–Š‡ˆ—–—”‡’Šƒ”ƒ…‘Ž‘‰‹•–™‘—Ž†‡ƒ•‹Ž›ˆ‹†–Š‡…—”‡ ˆ‘”–Š‡†‹•‡ƒ•‡•ǡ™Š‹…Š‹’”‡•‡–•…‡ƒ”‹‘‹•‘–’”‡•‡–Ǥ ȏʹȐ  ”‡‰‡‡”ƒ–‹˜‡ ’Šƒ”ƒ…‘Ž‘‰› ƒ† ’Šƒ”ƒ…‘Ǧ –Š‡”ƒ’‡—–‹…• …ƒ Š‡Ž’ ‹ †‡˜‹•‹‰ ‡™‡” ƒ† „‡––‡” …—”‡ –Š”‘—‰Š ”‡…‘•–”—…–‹‘ ƒ† ”‡’ƒ‹” ’”ƒ…–‹…‡• ‹••‹‰ ‹ –Š‡ Š—ƒ „‘†› ƒ† …ƒ ”‡ƒŽŽ› …Šƒ‰‡ –Š‡ ‘˜‡”ƒŽŽ •…‡ƒ”‹‘‘”–Š‡‘—–…‘‡ˆ”‘–Š‡‡™‡”†‡˜‡Ž‘’‡–•‹ –Š‡ ˆ‹‡Ž† ‘ˆ ’Šƒ”ƒ…‡—–‹…ƒŽ „‹‘–‡…Š‘Ž‘‰› ‘” ’Šƒ”ƒ…‡—–‹…ƒŽ‹†—•–”›ǡ‘”‹‘–Š‡”ƒ•’‡…–•‹–Š‡ˆ‹‡Ž†‘ˆ ‹‘–‡…Š‘Ž‘‰›Ǥ ‘–Š‡”™‘”†•ǡƒ‡‰‡‡”ƒ–‹˜‡’Šƒ”ƒ…‘Ž‘‰›‹•‘–Š‹‰ „—– ƒ ƒƒŽ‰ƒƒ–‹‘ ‘ˆ –™‘ ˆ‹‡Ž† ‘ˆ ‡†‹…ƒŽ •…‹‡…‡•ǡ ‹Ǥ‡Ǥǡ Šƒ”ƒ…‘Ž‘‰›ƒ†‹‘–‡…Š‘Ž‘‰›‘”‹‘Ǧ‡‰‹‡‡”‹‰Ǥ ‡…Š‘Ž‘‰›™‘—Ž†ƒ›™ƒ›•™‘—Ž†„”‹‰…Šƒ‰‡•‹‘– ‘Ž›‹–Š‡ˆ‹‡Ž†‘ˆ’Šƒ”ƒ…‘Ž‘‰›„—–ƒŽ•‘‹‘–Š‡”ƒ•’‡…–• ‘ˆ –Š‡ ‡†‹…ƒŽ •…‹‡…‡• •—…Š ƒ• ‹–‡”ƒŽ ‡†‹…‹‡•ǡ ‘” –Š‡ ‘„•–‡–”‹…•ǡ‡–…Ǥ Š‡ ƒƒŽ‰ƒƒ–‹‘ ‘ˆ „‹‘‡‰‹‡‡”‹‰ ‘” ”‡‡‰‹‡‡”‹‰ ƒ† ’Šƒ”ƒ…‘Ž‘‰› ™‘—Ž† ”‡•—Ž– ‹–‘ ‡‰‡‡”ƒ–‹˜‡ ’Šƒ”ƒ…‘Ž‘‰› ™Š‹…Š …‘—Ž† ‡˜‡ ™‘” ƒ– –Š‡ǡ Dzƒ‘DzȂ Ž‡˜‡ŽǤ ‡‰‡‡”ƒ–‹˜‡ ’Šƒ”ƒ…‘Ž‘‰› ™‘—Ž† Š‡Ž’ ‹ ”‡…‘•–”—…–‹‰ ƒ† ”‡Ǧ‡‰‹‡‡”‹‰ –Š‡ ’ƒ–Š™ƒ›• ƒ– –Š‡ ‘Ž‡…—Žƒ” Ž‡˜‡Ž ™Š‹…Š …ƒ Š‡Ž’ ‹ „”‹‰‹‰ ‘—– „‡––‡” –”‡ƒ–‡– ’”‘–‘…‘Ž• ‘” –Š‡ ”‡•—Ž– ˆ”‘ –Š‡ Ž‡ƒ† …‘’‘—†•ƒ’’Ž‹‡†‘”‹–”‘†—…‡†‹–Š‡’ƒ–‹‡–ǯ•„‘†›‹ ‘”†‡” –‘ ˆ‹† ƒ —‹˜‡”•ƒŽ …—”‡ ˆ‘” ƒ› –›’‡ ‘ˆ ’ƒ”–‹…—Žƒ” †‹•‡ƒ•‡‘”–Š‡ƒ‹Ž‡–•Ǥȏ͵Ȑ Š‹• ‹†‡ƒ ‘ˆ ƒƒŽ‰ƒƒ–‹‘ ‘ˆ „‹‘‡‰‹‡‡”‹‰ ƒ† ’Šƒ”ƒ…‘Ž‘‰›ˆ”‘‘—”•‹†‡ǡ‹•‹ƒˆˆ‹”ƒ–‹‘–Šƒ–ǡ‹–™‘—Ž† •’ƒ”†‹•…—••‹‘•ƒ‘‰–Š‡•…‹‡–‹ˆ‹…ˆ”ƒ–‡”‹–›ƒ…”‘••–Š‡ ™‘”Ž†ƒ†‡™‡”–‡…Š‘Ž‘‰‹‡•ƒ†ƒ”‡ƒ•‘”‰”‡›ƒ”‡ƒ•ǡ…ƒ „‡ Š‹‰ŠŽ› ‡š’Ž‘”‡† ‹ ‘”†‡” –‘ ‘˜‡ –‘™ƒ”†•ǡ ƒ†˜ƒ…‡• ‹ –Š‡‡†‹…ƒŽ•…‹‡…‡•Ǥ  REFERENCES

Šƒ”ƒ…‘Ž‘‰› ‹• –Š‡ •…‹‡…‡ ‘ˆ †”—‰• ƒ† •–—†› ‘ˆ ‡…Šƒ‹• ‘ˆ ƒ…–‹‘ ‘ˆ †”—‰• ƒ† Ž‡ƒ† …‘’‘—†• ‘ –Š‡ –ƒ”‰‡–•‘”–ƒ”‰‡–’”‘–‡‹•‘””‡…‡’–‘”‘Ž‡…—Ž‡•Ǥ ‹…‡ ƒ‰‡•ǡ ’Šƒ”ƒ…‘Ž‘‰› ƒ† ’Šƒ”ƒ…‘Ǧ–Š‡”ƒ’‡—–‹…• Šƒ˜‡ ‡‡”‰‡† ƒ† Šƒ˜‡ „‡‡ …‘–”‹„—–‹‰ –‘ –Š‡ Š‡ƒŽ–Š •…‹‡…‡• ƒ† ‡†‹…ƒŽ ‹†—•–”› –Š”‘—‰Š ‹–• ‹‘˜ƒ–‹‘ ƒ† ”‹‰‘”‘—• Šƒ”† ™‘” ‹ ‘”†‡” –‘ ˆ‹† ‹‘˜ƒ–‹˜‡ …—”‡ ƒ† –”‡ƒ–‡– ’”‘–‘…‘Ž•ǡ ˆ‘” –Š‡ ‡Šƒ…‡‡– ‘ˆ –Š‡ ‡†‹…ƒŽ •…‹‡…‡•ƒ†ˆ‘”–Š‡„‡‡ˆ‹–‘ˆƒ‹†Ǥ  ‡™‡” …‘…‡’– Šƒ• „‡‡ …‘‹‡†ǡ ™Š‹…Š ‹•ǡ Dz‡‰‡‡”ƒ–‹˜‡ Šƒ”ƒ…‘Ž‘‰›dzǤ Š‡ ”‡‰‡‡”ƒ–‹˜‡ ’Šƒ”ƒ…‘Ž‘‰›‹•†‡ˆ‹‡†ƒ•–Š‡’Šƒ”ƒ…‘Ž‘‰›—•‹‰‡™‡” –‘‘Ž• ƒ† –‡…Š‘Ž‘‰› ‹ ‘”†‡” –‘ ”‡…‘•–”—…– –Š‡ ”‡…‡’–‘” –ƒ”‰‡–• ƒ† …‡ŽŽ• ‘” ‘”‰ƒ …‘’‘‡–•ǡ ‹ ‘”†‡” –‘ ƒ†Œ—•– ™‹–Š –Š‡ ‡™Ž› †‡˜‡Ž‘’‡† Ž‡ƒ† …‘’‘—†• ˆ‘” –Š‡ „‡––‡” ‘—–…‘‡ ‘ˆ –Š‡”ƒ’‡—–‹…• ƒ’’Ž‹‡† ‹ ‘”†‡” –‘ …—”‡ ‘” ˆ‹† •‘Ž—–‹‘•ˆ‘”–Š‡‡˜‡”‹…”‡ƒ•‹‰…‘’Ž‡š‹–›‘ˆ–Š‡†‹•‡ƒ•‡• ƒ†ƒ‹Ž‡–•ƒ‘‰–Š‡Š—ƒ„‡‹‰•Ǥ Š‡’”‡•‡–Ž‡––‡”–‘–Š‡‡†‹–‘”Šƒ•„‡‡™”‹––‡–‘‡‡’ ‹–Š‡‹–‡”‡•–‘ˆ–Š‡•…‹‡–‹•–•ƒ†Š‡ƒŽ–Š…ƒ”‡’”ƒ…–‹–‹‘‡”• ƒ…”‘•• –Š‡ ™‘”Ž†ǡ –‘ †‹•…—•• ƒ† Šƒ˜‡ ƒ –Š‘—‰Š– ‘ –Š‹• ‡™Ž›‡‡”‰‹‰ˆ‹‡Ž†‘ˆ‡†‹…ƒŽ•…‹‡…‡Ǥ Šƒ”ƒ…‘Ž‘‰›‹•–Š‡•…‹‡…‡‘ˆˆ‹†‹‰‘—––Š‡ƒ–—”‡‘ˆ †”—‰• ƒ† ‘Ž‡…—Žƒ” ‡…Šƒ‹•• ‹ ‘”†‡” –‘ —†‡”•–ƒ† –Š‡ „‡Šƒ˜‹‘” ‘ˆ †”—‰•ǡ ‘” Ž‡ƒ† …‘’‘—†• ‘” –Š‡ ‡™Ž› †‡•‹‰‡† ‘Ž‡…—Ž‡• ‹•‹†‡ –Š‡ Š—ƒ „‘†› ƒ† ƒŽ•‘ –‘ —†‡”•–ƒ† –Š‡ „‡Šƒ˜‹‘” ‘ˆ Š—ƒ „‘†› ™‹–Š ”‡•’‡…– –‘ –Š‡•‡‘Ž‡…—Ž‡•ǤȏͳȐ ‡™Ž›…‘‹‡†–‡”ǡ‹Ǥ‡ǤǡDz‡‰‡‡”ƒ–‹˜‡Šƒ”ƒ…‘Ž‘‰›dzǡ Šƒ• ‡‡”‰‡† ‹ ”‡…‡– –‹‡•Ǥ Š‡ –‡” ”‡‰‡‡”ƒ–‹˜‡ ’Šƒ”ƒ…‘Ž‘‰› Šƒ• …Ž‘•‡ ”‡Žƒ–‹‘ ™‹–Š –Š‡ ”‡‰‡‡”ƒ–‹˜‡ ‡†‹…‹‡•ǡ ™Š‹…Š Šƒ• ƒŽ•‘ ‡‡”‰‡† ‡™Ž› ‹ –Š‡ ”‡…‡– –‹‡•Ǥ›–Š‡™‘”†ǡDz‡‰‡‡”ƒ–‹˜‡dz‹–Š‡‡†‹…ƒŽ™‘”Ž†ǡ‹– ‡ƒ• •‘‡–Š‹‰ –‘ ”‡…”‡ƒ–‡ ‘” –‘ ”‡…‘•–”—…–Ǥ Š‹• Šƒ• ™‹†‡ ƒ’’Ž‹…ƒ–‹‘ –‘ –Š‡ ‡†‹…ƒŽ •…‹‡…‡ ƒ† „‹‘Ž‘‰‹…ƒŽ •…‹‡…‡•ǡƒ•‹–’—”‡Ž›‡ƒ•…‘•–”—…–‹‰‡™…‡ŽŽ•ǡ‘”‰ƒ•ǡ ‘” ‹ –‡”• ‘ˆ ’Šƒ”ƒ…‘Ž‘‰›ǡ ”‡…‘•–”—…–‹‘ ‘” ”‡’ƒ‹” ‘ˆ –ƒ”‰‡–”‡…‡’–‘”•‹–Š‡…‡ŽŽ•ƒ†‘”‰ƒ•›•–‡•Ǥ ‡‰‡‡”ƒ–‹˜‡ Šƒ”ƒ…‘Ž‘‰› Š‘Ž†• ™‹†‡ ƒ’’Ž‹…ƒ–‹‘ –‘ –Š‡‡†‹…ƒŽ•…‹‡…‡ƒ†Š‡ƒŽ–Š…ƒ”‡‹†—•–”›ǡƒ•‹–™‹ŽŽŠ‡Ž’ ‹’—”‡Ž›”‡…‘•–”—…–‹‰–Š‡‘Ž†‡–Š‘†•™Š‹…ŠŠƒ˜‡ˆƒ‹Ž‡† –‘„”‹‰”‡•—Ž–•ǡ‹ƒ‡™‡”ƒ‡”™Š‹…Š™‘—Ž†—Ž–‹ƒ–‡Ž› ”‡•—Ž– ‹ –Š‡ †‡•‹”‡† ‘—–…‘‡• ‘” –Š‡ ”‡•—Ž–• ˆ”‘ ƒ ƒŽƒ •–‹–—–‡‘ˆ‡•‡ƒ”…Šƒ††˜ƒ…‡†–—†‹‡•ǡƒ”–ƒ’—”›’ƒ••‘ƒ†ǡ ‡‡”—–ǦʹͷͲͳͳͲǡ––ƒ””ƒ†‡•Šǡ †‹ƒǤ Ǧƒ‹Žǣ‡Š–ƒǤ†̷–”™”‹–‡”•Ǥ…‘ ȗ‘””‡•’‘†‹‰ƒ—–Š‘”  ʹ”ƒ•Žƒ •–‹–—–‡ ‘ˆ Šƒ”ƒ…‡—–‹…ƒŽ •…‹‡…‡•ǡ ƒ™ƒƒ ‘ƒ†ǡ ‡‡”—–Ǧ ʹͷͲͲͲͳǡ––ƒ””ƒ†‡•Šǡ †‹ƒǤ  ͵‡’ƒ”–‡– ‘ˆ Š›–‘…Š‡‹•–”› ƒ† Šƒ”ƒ…‘‰‘•›ǡ ƒ‹ƒ ƒ”†ƒ”†ǡ ‡™‡ŽŠ‹ǦͳͳͲͲͲͳǡ †‹ƒǤ ͳ

˜‡–‹ƒ’‹†ǣ‘Ž‡…—Žƒ”Šƒ”ƒ…‘Ž‘‰›‘ŽǤʹͲͳͻǡ ••—‡ͳ ȏ Ͳͻ͹͸Ǧ͵ͺͷ͸Ȑ

ͳǤ †‡”••‘  ƒ† Š”‹•–‰ Ǥ ‡‰‡‡”ƒ–‹˜‡ ’Šƒ”ƒ…‘Ž‘‰›ǣ –Š‡ ˆ—–—”‡‹•‘™Ǥ‘Ž –‡”˜ǡ7ȋʹȌǣ͹ͻȂͺ͸ǡʹͲͲ͹Ǥ ʹǤ ‘ƒ‰ƒ‹ ǡ ƒ•ƒ‰‹ ǡ ƒœœ‹‰Š‹ ǡ ƒœœ‡”‹  ƒ† ‘ƒ‰ƒ‹ Ǥ Šƒ”ƒ…‘Ž‘‰‹…ƒŽ ‘†—Žƒ–‹‘ ‘ˆ •–‡ …‡ŽŽ ˆ—…–‹‘Ǥ—””‡†Š‡ǡͳͶȋͳͲȌǣͳͳʹͻȂ͵ͻǡʹͲͲ͹Ǥ ͵Ǥ ƒœ‘Œ ǡ ‘‘”‘™•‹  ƒ† ‘Š… Ǥ –‡ …‡ŽŽ• ƒ† –‹••—‡ ‡‰‹‡‡”‹‰ ƒ’’Ž‹…ƒ–‹‘• ‘ˆ –Š‡ ‰‡‹–‘—”‹ƒ”› –”ƒ…–Ǥ ‡†‹ƒ–” ‡•ǡ͸͵ȋͷȌǣͶ͹ʹȂͶ͹͹ǡʹͲͲͺǤ

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ʹͲͳͻ’’ʹ͹ͷ͹ͺ ̹ ˜‡–‹ ‘—”ƒŽ•ȋȌ–† —„Ž‹•Š‡†‘‡„͵ͳȀͳʹȀʹͲͳͺǡ™™™Ǥ‹˜‡–‹Ǥ‹

     Cite this article as: ‡˜ƒ•Š ‡Š–ƒǡ ƒ”Š‹ ƒ•–‘‰‹ǡ ‘Š†Š—ƒ‹„ et alǤ Š‘”– ‘’”‡Š‡•‹˜‡ ƒ† ’‡”ƒ–‹˜‡ ‘–‡ ‘  ‡‰‡‡”ƒ–‹˜‡Šƒ”ƒ…‘Ž‘‰›Ǥ ˜‡–‹ƒ’‹†ǣ‘Ž‡…—Žƒ”Šƒ”ƒ…‘Ž‘‰›ǡʹͲͳͻȋͳȌǣͳǦʹǡʹͲͳͺǤ



˜‡–‹ƒ’‹†ǣ‘Ž‡…—Žƒ”Šƒ”ƒ…‘Ž‘‰›‘ŽǤʹͲͳͻǡ ••—‡ͳ ȏ Ͳͻ͹͸Ǧ͵ͺͷ͸Ȑ

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ʹͲͳͻ’’ʹ͹ͷ͹ͺ ̹ ˜‡–‹ ‘—”ƒŽ•ȋȌ–† —„Ž‹•Š‡†‘‡„͵ͳȀͳʹȀʹͲͳͺǡ™™™Ǥ‹˜‡–‹Ǥ‹