ORIGINAL RESEARCH published: 23 November 2017 doi: 10.3389/fphys.2017.00921
Acute Effects of Positive Airway Pressure on Functional Mitral Regurgitation in Patients with Systolic Heart Failure Takao Kato 1 , Takatoshi Kasai 1, 2*, Shoichiro Yatsu 1 , Azusa Murata 1 , Hiroki Matsumoto 1, 2 , Shoko Suda 1, 2 , Masaru Hiki 1 , Nanako Shiroshita 2 , Mitsue Kato 2 , Fusae Kawana 2 , Sakiko Miyazaki 1 and Hiroyuki Daida 1 1
Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan, 2 Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
Edited by: Jean-Pierre Montani, University of Fribourg, Switzerland Reviewed by: Jie Liu, Fourth Military Medical University, China Diego Arroyo, University of Fribourg, Switzerland Shin-ichi Ando, Kyushu University Hospital, Japan *Correspondence: Takatoshi Kasai
[email protected] Specialty section: This article was submitted to Integrative Physiology, a section of the journal Frontiers in Physiology Received: 18 July 2017 Accepted: 31 October 2017 Published: 23 November 2017 Citation: Kato T, Kasai T, Yatsu S, Murata A, Matsumoto H, Suda S, Hiki M, Shiroshita N, Kato M, Kawana F, Miyazaki S and Daida H (2017) Acute Effects of Positive Airway Pressure on Functional Mitral Regurgitation in Patients with Systolic Heart Failure. Front. Physiol. 8:921. doi: 10.3389/fphys.2017.00921
Frontiers in Physiology | www.frontiersin.org
Background: Acute effects of positive airway pressure (PAP) [including continuous PAP (CPAP) and adaptive servo-ventilation, an advanced form of bi-level PAP] on functional mitral regurgitation (fMR) in patients with heart failure (HF) with left ventricular (LV) systolic dysfunction remain unclear. Thus, whether PAP therapy reduces fMR in such patients with HF was investigated. Methods and Results: Twenty patients with HF and LV systolic dysfunction defined as LV ejection fraction (LVEF)
