Feb 10, 2018 - 2Angers University Hospital, Intensive Care Unit, Angers, FRANCE, ... Nantes, FRANCE, 12Centre Hospitalier du Mans, Intensive care unit, ...
Nephrology Dialysis Transplantation 31 (Supplement 1): i147–i159, 2016 doi:10.1093/ndt/gfw162.32
ACUTE KIDNEY INJURY. CLINICAL SP213
OUTCOME OF AAV PATIENTS WITH ACTIVE DISEASE ADMITTED TO THE ICU: A COMPARATIVE MULTICENTER STUDY
Jean-François Augusto1, Julien Demiselle1, Johann Auchabie2, Philippe Gatault3, François Beloncle2, Steven Grange4, Damien Du Cheyron5, Jean Dellamonica6, Sonia Boyer7, Dimitri Titeca8, Lise Piquilloud 9, Julien Letheulle10, Christophe Guitton11, Nicolas Chudeau12, Guillaume Géri13, François Fourrier14, René Robert15, Jean-Luc Diehl16, Julie Boisramé-Helms17, Pierre-François Dequin18, Alexandre Lautrette19, Pierre Edouard Bollaert20, Ferhat Meziani21, Loïc Guillevin22 and Nicolas Lerolle23 1 Angers University Hospital, Nephrology-Dialysis-transplantation, Angers, FRANCE, 2 Angers University Hospital, Intensive Care Unit, Angers, FRANCE, 3CHRU de Tours, Service de Néphrologie et Immunologie Clinique, Tours, FRANCE, 4Rouen University Hospital, Medical Intensive Care, Rouen, FRANCE, 5Caen university hospital, Medical Intensive Care, Caen, FRANCE, 6Nice University hospital, Medical intensive Care Unit, Nice, FRANCE, 7CHU Nice, Medical Intensive Care Unit, Nice, FRANCE, 8Amiens University Medical Center, Medical intensive Care Unit, Amiens, FRANCE, 9Centre Hospitalier Universitaire Vaudois, Service de médecine intensive adulte et centre des brûlés, Lausanne, SWITZERLAND, 10 Hôpital Pontchaillou CHU Rennes, Service de réanimation médicale, Rennes, FRANCE, 11Hôtel-Dieu, University Hospital of Nantes, Medical Intensive Care Unit, Nantes, FRANCE, 12Centre Hospitalier du Mans, Intensive care unit, Le Mans, FRANCE, 13Hôpital Cochin, Service de réanimation médicale, Paris, FRANCE, 14 Lille University hospital, Réanimation, centre de réanimation,, Lille, FRANCE,
15 CHU de Poitiers, Service de réanimation médicale, Poitiers, FRANCE, 16Hôpital Européen Georges Pompidou, Service de réanimation médicale, Paris, FRANCE, 17 Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Service de Réanimation Médicale, Strasbourg, FRANCE, 18CHU de Tours, Service de réanimation polyvalente, Tours, FRANCE, 19CHU de Clermont-Ferrand, Service de Réanimation Médicale Polyvalente, Clermont-Ferrand, FRANCE, 20CHU de Nancy, Service de réanimation médicale Polyvalente, Nancy, FRANCE, 21Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Service de Réanimation Médicale Polyvalente, Strasbourg, FRANCE, 22Assistance public des hôpitaux de Paris, Hôpital Cochin, Département de médecine interne, Paris, FRANCE, 23Angers University Hospital, Medical Intensive Care, Angers, FRANCE
Introduction and Aims: ANCA-associated vasculitis (AAV) patients requiring intensive cares have been poorly analyzed. The objective of this study was to analyze the characteristics of AAV patients admitted to ICU with AAV activity. Methods: Consecutive AAV patients (2002-2012) admitted to 17 ICUs were evaluated and compared to AAV patients admitted to 2 nephrology departments (non-ICU). Results: 97 and 95 patients were included in the ICU group and in the non-ICU group, respectively. The ICU group had predominantly GPA and PR3-ANCAs and showed higher frequency of heart, central nervous system (CNS) and diffuse alveolar hemorrhage (DAH). Fifteen patients died during ICU stay. Respiratory assistance, vasopressor use, infectious events, SOFA and SAPSII were significantly associated with mortality. In the multivariate analysis, only infectious events (OR 20.5, p=0.005) and SAPSII (OR 1.1, p=0.009) remained associated with mortality. Despite a higher initial mortality during the first hospital stay ( p
