Adam 10 - Adam 17

Adam 10 - Adam 17

0.2

Homo sapiens 1 Homo sapiens 29 Homo sapiens 25 53.1 51.1 Homo sapiens 30 87.6 Homo sapiens 2 Homo sapiens 9 92.1 Oscarella carmela 14 Homo sapiens 8 97.9 58.9 Homo sapiens 19 Homo sapiens 11 Encephalitozoon cuniculi Schizosaccharomyces pombe Aspergillus fumigatus A 99.5 Aspergillus fumigatus B 97.6 Ustilago maydis Amphimedon queenslandica 100 Hydra magnipapillata 10a Hydra magnipapillata 10b 79.2 87.8 Nematostella vectensis 10a Trichoplax adhaerens 10a 88.7 99.9 Trichoplax adhaerens 10b Aedes aegypti 10a 52.9 Nematostella vectensis 10b Strongylocentrotus purpuratus 56 ฀ Caenorhabditis elegans 10 94.3 Aedes aegypti 10b 76.4 Lottia gigantea 10 94.9 100 Helobdella robusta 10a Helobdella robusta 10b 56.2 Xenopus tropicalis 10a 99.9 Danio rerio 10a 100 Danio rerio 10b 96.4

95.2

52

99.1

92.6 55.6 59.9 63

52.2

฀

Gallus gallus 10 79 Homo sapiens 10 61.1 Xenopus tropicalis 10b 100 Danio rerio 10c 96 Danio rerio 10d Ciona intestinalis 10 Nematostella vectensis 10c Monosiga brevicolis 10a Monosiga brevicolis 10b Monosiga brevicolis 17a Monosiga brevicolis 17b Hydra magnipapillata 17 Pleurobrachia pileus 17 Oscarella carmela 17 Caenorhabditis elegans 17 Trichoplax adhaerens 17 Amphimedon queenslandica 17 Aedes aegypti 17 Lottia gigantea 17 Ciona intestinalis 17 Xenopus tropicalis 17 97.6 Gallus gallus 17 93.9 Homo sapiens 17a 100 100 Homo sapiens 17b 96.7

Danio rerio 17a Danio rerio 17b Branchiostoma floridae 17 Nematostella vectensis 17 Strongylocentrotus purpuratus 17

Aph1

0.2 Volvox carteri 96.6 Arabidopsis thaliana

66.8

Phytophthora ramorum Dictyostelium discoidum Monosiga brevicolis Amphimedon queenslandica

97.4

Helobdella robusta 77.9 Hydra magnipapillata 97.3

Nematostella vectensis 98.2 Nematostella vectensis Aedes aegypti Lottia gigantea Danio rerio 1 Gallus gallus Homo sapiens 1 98.5 Xenopus tropicalis

99.3

Homo sapiens 2 100 Homo sapiens 3 Danio rerio 2 Strongylocentrotus purpuratus 58.4 Branchiostoma floridae Ciona intestinalis Trichoplax adhaerens

Deltex 0.2 Trichoplax adhaerens Aedes aegypti

97.7 79.5

Amphimedon queenslandica

71.8

Nematostella vectensis 61

Ciona intestinalis Helobdella robusta 2a

91.8

Helobdella robusta 2b Strongylocentrotus purpuratus

56.8 100

Branchiostoma floridae a Branchiostoma floridae b

59.5

Danio rerio 2 71.4 Homo sapiens 2 77.9

98.7

Gallus gallus 2a

Xenopus tropicalis 2 75.3 Homo sapiens 4

90.2

Gallus gallus 2b Danio rerio 1

79.8

Xenopus tropicalis 1 Homo sapiens 1

100

Xenopus tropicalis 4

Homo sapiens 3b Homo sapiens 3c Lottia gigantea 3

Gallus gallus 3 Nematostella vectensis 3a

71.6

Ciona intestinalis 3a

59.5

Ciona intestinalis 3b

60.9

Ciona intestinalis 3c Nematostella vectensis 3b Danio rerio 3b Danio rerio 3a 84.9 95.3

Homo sapiens 3a Xenopus tropicalis 3 Monosiga brevicolis Lottia gigantea

Fringe

0.5

53.3

Trichomonas vaginalis Amphimedon queenslandica 5 Amphimedon 100 queenslandica 6 Amphimedon 91.2 queenslandica 1 Amphimedon queenslandica 2 Amphimedon 99.9 queenslandica 3 Amphimedon queenslandica 4 Nematostella vectensis 1 100 Nematostella vectensis 2 Ciona intestinalis 5 Ciona intestinalis 2

98.8

100

88.2

62.4

Ciona intestinalis 1 Ciona intestinalis 3

71.7 85.9

Ciona intestinalis 4 Ciona intestinalis 6

97

Ciona intestinalis 7 Danio rerio Radical 99.8

Homo sapiens Radical

63.6

73.5

Gallus gallus Radical 100

92.6

Xenopus tropicalis Radical 2 Xenopus tropicalis Radical 1

Danio rerio Lunatic 77

Xenopus tropicalis Lunatic Gallus gallus Lunatic 1 96.4 Gallus gallus Lunatic 2 Homo sapiens Lunatic

60.4

Danio rerio Manic 97.2 66.1

Homo sapiens Manic Gallus gallus Manic

51.8

Lottia gigantea Aedes aegypti Capitella Sp1 Strongylocentrotus purpuratus 1 Branchiostoma floridae Arabidopsis thaliana

&URIN 0.2 100

78

69

58

85

Schizosaccharomyces pombe 1 Schizosaccharomyces pombe 2 +EX Ustilago maydis Nematostella vectensis 10 Branchiostoma floridae 7 100 Branchiostoma floridae 8 Ciona intestinalis 5 0#3+ Xenopus tropicalis 7 82 Homo sapiens 6 73 gallus 9 86 70 Gallus Gallus gallus 7 Gallus gallus 6 Danio rerio 6 Trichoplax adhaerens 3 Ciona intestinalis 3 Homo sapiens 10 Amphimedon queenslandica Oscarella carmela Gallus gallus 8 Trichoplax adhaerens 2 Nematostella vectensis 9 Ciona intestinalis 2 Hydra magnipapillata 1 Nematostella vectensis 3 Helobdella robusta 5

100 83 55 67

853

74

99 88 100

Aedes aegypti 3

Caenorhabditis elegans 1 Lottia gigantea 2 Lottia gigantea 3 Xenopus tropicalis 2 100 Homo sapiens - PCSK4 Gallus gallus 3 999 96 Homo sapiens - furin 97 &URIN 99 Xenopus tropicalis 9 Danio rerio 2 99 Danio rerio 3 Strongylocentrotus purpuratus Branchiostoma floridae 100 Branchiostoma floridae 3 Ciona intestinalis 4 Gallus gallus 2 74 Homo sapiens 1 100 0ACE! Xenopus tropicalis 5 Danio rerio 5 88 Danio rerio 7 Danio rerio 8 100 Xenopus tropicalis 6 Xenopus tropicalis 3 Homo sapiens 4 100 Homo sapiens 8 Homo sapiens 7 72 Gallus gallus 5 Helobdella robusta 3 68 Helobdella robusta 2 997 64 Helobdella robusta 4 Helobdella robusta 6 68 gigantea 1 100 Lottia Lottia gigantea 5 91 Lottia gigantea 4 8 77 Lottia gigantea Caenorhabditis elegans 3 Aedes aegypti 4 Trichoplax adhaerens Lottia gigantea 6 998 Lottia 998 gigantea 10 97 100 Lottia gigantea 7 Helobdella robusta 1 0#3+ 93 Xenopus tropicalis 4 100 Danio rerio 1 80 Gallus gallus 4 75 Homo sapiens 3 81 Branchiostoma floridae 2 Helobdella robusta 7 97 96 Caenorhabditis elegans 2 100 Aedes aegypti 2 Ciona intestinalis 1 Branchiostoma floridae 4 69 0#3+ 99 Danio rerio 4 98 100 Xenopus tropicalis 1 Xenopus tropicalis 8 91 Homo sapiens 2 95 Gallus gallus 1 Nematostella vectensis 2 Pleurobrachia pileus Nematostella vectensis 7 98 Nematostella vectensis 8 Nematostella vectensis 5 Nematostella vectensis 13 Nematostella vectensis 12 Hydra magnipapillata 2 Nematostella vectensis 11 Nematostella vectensis 6 Lottia gigantea 9 81 Helobdella robusta 9 Branchiostoma floridae 10 100 Branchiostoma floridae 6 Branchiostoma floridae 9 Monosiga brevicolis

Branchiostoma floridae 16

floridae 17 99.9 99.6 Branchiostoma Branchiostoma floridae 11

Branchiostoma floridae 12 Branchiostoma floridae 13 Helobdella robusta 8

999

0#3+

&URIN

Mastermind

0.2 Nematostella vectensis

Branchiostoma floridae

Homo sapiens 1c

100 Homo sapiens 1b 100

Homo sapiens 1a

99.8

Gallus gallus 1

Xenopus tropicalis 1 94.9

Danio rerio 3


99.7

Homo sapiens 3b

98.8 100

Homo sapiens 3a 53.6

Gallus gallus 3

Mindbomb 0.1 Nematostella vectensis 2 Amphimedon queenslandica 2 Ciona intestinalis 2 Danio rerio 2a 100 Danio rerio 2b 61.8

Homo sapiens 2a 100 100 Homo sapiens 2b Homo sapiens 2c

97.9 97.2

Xenopus tropicalis 2 62.5 Gallus gallus 2 Aedes aegypti 2 Amphimedon queenslandica 1 Aedes aegypti 1 79.4

Lottia gigantea 1a 100 Lottia gigantea 1b Lottia gigantea 1c

54.2

Helobdella robusta Strongylocentrotus purpuratus Nematostella vectensis 1 54.9 Hydra magnipapillata Ciona intestinalis 1a 100 Ciona intestinalis 1b 100 Ciona intestinalis 1c Danio rerio 1 98.9

Homo sapiens 1 97 Gallus gallus 1 Xenopus tropicalis 1

Nedd4 1 99.6

Xenopus tropicalis 1 Xenopus tropicalis 2 Danio rerio 8 Gallus gallus 8 Homo sapiens 8

99.1

Monosiga brevicolis 4 Monosiga brevicolis 5 Monosiga brevicolis 12 77 Pleurobrachia pileus Lottia gigantea 3 73 54 Caenorhabditis elegans 1 Nematostella vectensis 3 Trichoplax adhaerens 2 Strongylocentrotus purpuratus 4 Aedes aegypti 2 100 Aedes aegypti 3 Branchiostoma floridae Ciona intestinalis 2 Danio rerio 6 98 68 Gallus gallus 3 Homo sapiens 2 Homo sapiens 5 Xenopus tropicalis 8 52 100 Xenopus tropicalis 9 Danio rerio 5 Gallus gallus 7 92 Homo sapiens 1 Homo sapiens 3 100 Homo sapiens 9 Oscarella carmela Xenopus tropicalis 5 Schizosaccharomyces pombe 2 86 61 Schizosaccharomyces pombe 1 Schizosaccharomyces pombe 3 Ustilago maydis 1 63 Saccharomyces cerevisiae Encephalitozoon cuniculi Monosiga brevicolis 11 Monosiga brevicolis 3 Naegleria gruberi Ustilago maydis 2 Arabidopsis thaliana 74 Volvox carteri 54 Phytophthora ramorum Phytophthora sojae 100 Plasmodium falciparum Leishmania major Monosiga brevicolis 9 96 Monosiga brevicolis 7 Dictyostelium discoidum 65 Entomoeba histolytica Helobdella robusta 5 96 Nematostella vectensis 4 Lottia gigantea 2 Aedes aegypti 5 Ciona intestinalis 3 100Danio rerio 2 91 Danio rerio 4 Gallus gallus 1 99 Homo sapiens 7 Gallus gallus 4 Homo sapiens 4 100 Danio rerio 1 Danio rerio 3 Xenopus tropicalis 4 98 Xenopus tropicalis 7 Monosiga brevicolis 2 Caenorhabditis elegans 2 Monosiga brevicolis 6 Trichoplax adhaerens 3 99 Helobdella robusta 4 Monosiga brevicolis 1 Trichoplax adhaerens 1 100 Strongylocentrotus purpuratus 2 Strongylocentrotus purpuratus 3 Aedes aegypti 4 99 Ciona intestinalis 1 Amphimedon queenslandica Nematostella vectensis 8 Gallus gallus 6 98 100 Homo sapiens 6 83 Gallus gallus 2 93 Homo sapiens Itch ITCH 100 Xenopus tropicalis 3 75 Xenopus tropicalis 6 Gallus gallus 5 100 Homo sapiens 10 Danio rerio 7 54 Helobdella robusta 3 Hydra magnipapillata 1 Caenorhabditis elegans 3 77 Helobdella robusta 2 Helobdella robusta 1 Lottia gigantea 1

PUB


Danio rerio 9

Nematostella vectensis 2 Gallus gallus 9 Aedes aegypti 1

0.2

Neuralized

Danio rerio 1a 100

Danio rerio 1b 85.9 Homo sapiens 1 75.3 Gallus gallus 1 93.7 Xenopus tropicalis 1

100

Gallus gallus 2a 100 50.6

Gallus gallus 2b

Xenopus tropicalis 2 99.9 Homo sapiens 2 97.2 Danio rerio 2b 99.2 Danio rerio 2a

Branchiostoma floridae 1 Branchiostoma floridae 2 100 Ciona intestinalis

Lottia gigantea 1 100 95.9

Lottia gigantea 2 Helobdella robusta

89.4 Caenorhabditis elegans 1 100 Caenorhabditis elegans 2

59 Aedes aegypti

Strongylocentrotus purpuratus Ciona intestinalis

Nicastrin 0.2 Phytophthora ramorum Phytophthora sojae Arabidopsis thaliana 100 Volvox carteri Dictyostelium discoidum 100 Pleurobrachia pileus Monosiga brevicolis Amphimedon queenslandica Aedes aegypti Caenorhabditis elegans Helobdella robusta Danio rerio 95.9

Gallus gallus 81

Homo sapiens 4 97.9 Homo sapiens 3

75.4 Homo sapiens 2 57.7 Homo sapiens 1 Hydra magnipapillata 98.1 Xenopus tropicalis Lottia gigantea 58.1 Branchiostoma floridae Trichoplax adhaerens 52.6 Nematostella vectensis Strongylocentrotus purpuratus

Notchless 0.2 Trichomonas vaginalis Naegleria gruberi Tetrahymena thermophila

53.5 Leishmania major Phytophthora ramorum 100 Phytophthora sojae Volvox carteri 71.6 Arabidopsis thaliana Entomoeba histolytica Aedes aegypti Caenorhabditis elegans

Monosiga brevicolis 53.9 Pleurobrachia pileus 70.8

Trichoplax adhaerens Xenopus tropicalis 98.9

Danio rerio

68.5 Homo sapiens 69.3 Gallus gallus Branchiostoma floridae Hydra magnipapillata Helobdella robusta Ciona intestinalis Amphimedon queenslandica

75.4

Strongylocentrotus purpuratus Lottia gigantea Nematostella vectensis Ustilago maydis

91.2 Schizosaccharomyces pombe 99.8 Saccharomyces cerevisiae

0.2

.5-"

Trichoplax adhaerens 61.8 Hydra magnipapillata

Nematostella vectensis Strongylocentrotus purpuratus 2 100 Strongylocentrotus purpuratus 1

Caenorhabditis elegans 81 Helobdella robusta

99.8 85.3 77.6

Lottia gigantea

Aedes aegypti


Ciona intestinalis

Danio rerio 2 93.5 Danio rerio 1

Xenopus tropicalis 3 100

97.7 100


Homo sapiens 4

51.6

Gallus gallus Homo sapiens 3

Homo sapiens 2 83.798.5 Homo sapiens 1


Pen 2 0.2 Arabidopsis thaliana

Dictyostelium discoidum 73.5 Mnemiopsys leidyi

Aedes aegypti

Entamoeba histolytica Helobdella robusta

Caenorhabditis elegans

Trichoplax adhaerens

Hydra magnipapillata 83.4 Nematostella vectensis



Strongylocentrotus purpuratus

Ciona intestinalis

Lottia gigantea

Homo sapiens 92.8 Xenopus tropicalis

Danio rerio

Presenilin 0.2 100

Phytophthora ramorum Phytophthora sojae

Volvox carteri

100

Arabidopsis thaliana Entomoeba histolytica Leishmania major Dictyostelium discoidum 56.2

Trichomonas vaginalis Monosiga brevicolis Amphimedon queenslandica

63.2

Trichoplax adhaerens 98.5 Hydra magnipapillata 65.4

85.6



Branchiostoma floridae Lottia gigantea Ciona intestinalis 1a 100 Ciona intestinalis 1b Danio rerio 2c 66.5 98.6

98.8

Xenopus tropicalis 2 93.1 Gallus gallus 2 96.2 Homo sapiens 2

100

Danio rerio 2b Danio rerio 2a

99.8 Gallus gallus 1 Xenopus tropicalis 1 76.4 Homo sapiens 1 Helobdella robusta 2a

87.7 Helobdella robusta 2b Pleurobrachia pileus Anopheles gambiae Strongylocentrotus purpuratus 2a 100 Strongylocentrotus purpuratus 2b Strongylocentrotus purpuratus 2c

Strawberry Notch

0.2 Oscarella carmela Nematostella vectensis Trichoplax adhaerens Monosiga brevicolis Danio rerio 2 Xenopus tropicalis 2a

64.2

73.2 Xenopus tropicalis 2b Gallus gallus 2 73.9 Homo sapiens 2

Strongylocentrotus purpuratus 1 Trichoplax adhaerens 1 Hydra magnipapillata 1 Caenorhabditis elegans 1a 100 Caenorhabditis elegans 1b Amphimedon queenslandica 1 Nematostella vectensis 1 Ciona intestinalis 1 Gallus gallus 1 97.6 Homo sapiens 1 Branchiostoma floridae 1 Helobdella robusta 1 66.4 Lottia gigantea 1 Aedes aegypti 1 Arabidopsis thaliana Volvox carteri

3U( 0.2 Ustaligo maydis 1

Schizosaccharomyces pombe

Ustaligo maydis 2

Monosiga brevicolis 100 Homo sapiens 100 79.7 Gallus gallus 1

Ciona intestinalis 2 54.2 Caenorhabditis elegans


Trichoplax adhaerens 73.1 Nematostella vectensis Lottia gigantea 51.2 Helobdella robusta

Aedes aegypti

Branchiostoma floridae 77.3 Ciona intestinalis 1

69

Xenopus tropicalis

99.1

Gallus gallus 2

Homo sapiens 2 54.8 Danio rerio 2 79.5 Danio rerio 1