Alpha/Beta Interferon and Gamma Interferon ... - Journal of Virology

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JOURNAL OF VIROLOGY, Nov. 2002, p. 11541–11550 0022-538X/02/$04.00⫹0 DOI: 10.1128/JVI.76.22.11541–11550.2002 Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Vol. 76, No. 22

Alpha/Beta Interferon and Gamma Interferon Synergize To Inhibit the Replication of Herpes Simplex Virus Type 1 Bruno Sainz, Jr., and William P. Halford* Department of Microbiology and Immunology, Tulane University Health Sciences Center, Program in Molecular Pathogenesis and Immunity, New Orleans, Louisiana 70112 Received 23 May 2002/Accepted 14 August 2002

In vivo evidence suggests that T-cell-derived gamma interferon (IFN-␥) can directly inhibit the replication of herpes simplex virus type 1 (HSV-1). However, IFN-␥ is a weak inhibitor of HSV-1 replication in vitro. We have found that IFN-␥ synergizes with the innate IFNs (IFN-␣ and -␤) to potently inhibit HSV-1 replication in vitro and in vivo. Treatment of Vero cells with either IFN-␤ or IFN-␥ inhibits HSV-1 replication by

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