Apr 4, 2006 - Effectiveness trials in hypertension enable the ... E-mail: [email protected] ... achieved, effectiveness studies provide an opportu-.
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An Effectiveness Study Comparing Algorithm-Based Antihypertensive Therapy With Previous Treatments Using Conventional and Ambulatory Blood Pressure Measurements Michael A. Weber, MD;1 William B. White, MD;2 Thomas D. Giles, MD;3 George L. Bakris, MD;4 Joel M. Neutel, MD;5 David H.G. Smith, MD;5 Giora Davidai, MD6
Effectiveness trials in hypertension enable the efficacy and safety of new drugs to be compared with previous therapy. Since these open-label trials could inadvertently be influenced by observer bias, this study has used ambulatory blood pressure monitoring (ABPM) to provide a rigorous blinded end point to validate the study conclusions. The study was performed in 675 patients with stage 1 or 2 hypertension despite receiving single-agent or fixed-dose combination therapy. After baseline ABPM, the previous treatment was replaced by telmisartan 40 mg daily; if control (office blood pressure
