Anabolic steroid-induced hypogonadism: a

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The history of the use of anabolic androgenic steroids (AAS) is older than we think. Dr. Brown-Seuard injected himself with “or- chitic fluid” extracted from ...


Journal of Exercise Rehabilitation 2018;14(1):2-3

Anabolic steroid-induced hypogonadism: a challenge for clinicians Hyun Jun Park

The history of the use of anabolic androgenic steroids (AAS) is older than we think. Dr. Brown-Seuard injected himself with “orchitic fluid” extracted from laboratory animals to improve his aging symptoms and reported improvement (Dotson and Brown, 2007). Since the introduction of oral methyltestosterone in 1935, the use of synthetic androgen has started in earnest. Since the 1950s, the structure of testosterone has been modified to increase the anabolic effect and minimize the androgenic effect, resulting in various AASs (Kicman, 2008). However, the use of AAS was not free from the characteristic sequelae of the use of androgen and resulted in an unfavorable side effect of anabolic steroid-induced hypogonadism (ASIH). ASIH is common as a cause of secondary hypogonadism in young men, especially because young men often use AAS (Coward et al., 2013; Jarow and Lipshultz, 1990). In young men, hypogonadism not only is a problem but also can cause a more serious problem such as infertility. Since AASs began to be used by Olympic athletes to improve performance in the 1950s, associated sports issues have emerged and now expanded to public health issues issues (Franke and Berendonk, 1997). The reason is that much more men actually use AAS indiscriminately. Among male gym attendees, the reported rate of using AAS ranges from 15% to 30% (Perry et al., 1992). In other words, as we often think or as coverage by mass media, AAS is not the problem of other worlds that only professional athletes use. The reality is that because of simple greed, four of five people use AAS to improve their appearance (Cohen et al., 2007; Ip et al., 2011; Parkinson and Evans, 2006; Perry et al., 1992). A serious problem is that clinicians, even endocrinologists and andrologists, do not have much information and knowledge about AAS. This is

a reality from the lack of large well-designed studies on AAS and ASIH. AAS users get information about AAS from the Internet, blogs, social networking service, or self-named “expert nutritionists” who work in gyms. AAS is purchased through the Internet, and Internet suppliers sell bundled packages, including selective estrogen receptor modulators (SERMs), aromatase inhibitors, human chorionic gonadotropin (hCG), and phosphodiesterase-5 inhibitors (Cordaro et al., 2011; Cooper et al., 2013; Pirola et al., 2010). This means that not only the use of AAS but also the treatment of ASIH occurring after AAS is solved by AAS users themselves, not by the medical system. The pathophysiology of ASIH can be explained by the fact that AAS induces feedback suppression of the hypothalamic-pituitary-gonadal axis. Inhibition of pulsatile gonadotropin-releasing hormone release results in a decrease in luteinizing hormone and follicle-stimulating hormone (Rahnema et al., 2014). The main symptoms of ASIH are low endogenous testosterone levels, gynecomastia, testicular atrophy, sexual dysfunction, hepatic dysfunction, and alopecia. To restore ASIH, treatment strategies that increase the production of endogenous testosterone through treatment such as testosterone replacement, SERMs, and hCG should be done through accurate diagnosis and consultation with medical professionals. In the sports athletic field, strict standards have been established and thorough doping tests have been conducted. However, no standard and regulation have been established for public use of AAS yet. To prevent the spread of the use of AAS in an indiscriminate way by noncompetitive athletes, it should be accepted as an important public health issue and public education should be strengthened through mass media. On the one hand, clinicians This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Copyright © 2018 Korean Society of Exercise Rehabilitation


pISSN 2288-176X eISSN 2288-1778

Park HJ • Anabolic steroid-induced hypogonadism

should have sufficient knowledge of AAS use, concepts of ASIH, and treatment strategies. Through counseling with AAS users, clinicians should understand why patients use AAS and what medical problems they are currently facing.

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Department of Urology, Pusan National University School of Medicine, 179 Gudeok-ro, Seo-gu, Busan 49241, Korea E-mail: [email protected]