synergistic action between cAMP- and calcium-mediated re- sponses has ...... 75:462-471. 14. Mandel, K. G., J. A. McRoberts, G. Beuerlein, E. S. Foster, and.
Synergistic Action of Cyclic Adenosine Monophosphate- and Calcium-mediated Chloride Secretion in a Colonic Epithelial Cell Line Christine A. Cartwright, James A. McRoberts, Kenneth G. Mandel, and Kiertisin Dharmsathaphom Department of Medicine, University of California, San Diego, California 92103
Abstract Vasoactive intestinal polypeptide (VIP) and the calcium ionophore A23187 caused dose-dependent changes in the potential difference and the short circuit current (I.) across confluent T84 cell monolayers mounted in modified Ussing chambers. Both VIP and A23187 stimulated net chloride secretion without altering sodium transport. Net chloride secretion accounted for the increase in I,
