who develop ovarian hyperandrogenism post menarche may present .... All subjects had normal glucose ... or less in the PP group (PP: 37.0% of all alleles were 20 repeats or less, vs. .... or android, distribution of body fat (32), and thus further.
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The Journal of Clinical Endocrinology & Metabolism 88(7):3333–3338 Copyright © 2003 by The Endocrine Society doi: 10.1210/jc.2002-021791
Androgen Receptor Gene CAG Repeat Polymorphism in the Development of Ovarian Hyperandrogenism ´N ˜ EZ, KEN K. ONG, NIGEL MONGAN, JARMO JA ¨A ¨ SKELA ¨ INEN, LOURDES IBA MARIA VICTORIA MARCOS, IEUAN A. HUGHES, FRANCIS DE ZEGHER, AND DAVID B. DUNGER Endocrine Unit (L.I.), Hospital Sant Joan de De´u, University of Barcelona, E-08950 Barcelona, Spain; Department of Paediatrics (K.K.O., N.M., J.J., I.A.H., D.B.D.), University of Cambridge CB2 2QQ, United Kingdom; Endocrine Unit (M.V.M.), Consorci Hospitalari de Terrassa, Barcelona, Spain; and Department of Paediatrics (F.D.Z.), University of Leuven, B-3000 Leuven, Belgium Ovarian hyperandrogenism, a key feature of polycystic ovary syndrome, is preceded by precocious pubarche (PP) (pubic hair < 8 yr) in some populations. We hypothesized that this earlier presentation may relate to increased androgen sensitivity, indicated by androgen receptor gene CAG repeat length. This polymorphism was genotyped in 181 Barcelona girls (age, 10.9 yr; range, 4 –19 yr) who had presented with PP, and in 124 Barcelona control girls. PP girls had shorter mean CAG number than Barcelona controls (PP vs. controls: mean, range: 21.3, 7–31 repeats vs. 22.0, 15–32, P ⴝ 0.003) and greater proportion of short alleles 20 repeats or less (37.0% vs. 24.6%, P ⴝ 0.002). Among post-menarcheal PP girls (n ⴝ 69), shorter CAG number (biallelic mean
