G Cambridge, D S Rampton, T R J Stevens, D A McCarthy, M Kamm, B Leaker. Abstract. Anti-neutrophil antibodies have been shown in sera from patients with a ...
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Gut, 1992, 33, 668-674
Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role G Cambridge, D S Rampton, T R J Stevens, D A McCarthy, M Kamm, B Leaker
Department of Renal Medicine, Institute of Urology, University College and Middlesex School of Medicine, London, WI G Cambridge
Abstract Anti-neutrophil antibodies have been shown in sera from patients with a variety of inflammatory diseases. Those reacting with components of neutrophil cytoplasm are associated with systemic vasculitis. Both nuclear and perinuclear staining patterns on human neutrophils have been reported using sera from patients with inflammatory bowel disease. We have evaluated the reactivity against human neutrophils of sera from 100 patients with inflammatory bowel disease, 14 disease controls, and 20 normal volunteers. Altogether 27/50 (54%) sera from patients with ulcerative colitis contained antibodies that reacted with cytospun ethanol fixed neutrophils compared with 5/50 (10%) from Crohn's disease (p
