Baseline high grade resistance (HR) was defined as !4 nucleoside analogue mutations ... outcomes of genotyping directed second line therapy in Thai children who have ... between 10 and 60, the intermediate susceptibility was calculated.
International Journal of Infectious Diseases 14 (2010) e311–e316
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Antiretroviral treatment outcome following genotyping in Thai children who failed dual nucleoside reverse transcriptase inhibitors§ Torsak Bunupuradah a,*, Piyarat Suntarattiwong b, Andrea Li a,c, Sunee Sirivichayakul d, Chitsanu Pancharoen d, Pitch Boonrak a, Thanyawee Puthanakit a,d, Stephen J. Kerr a,e, Kiat Ruxrungtham a,d, Tawee Chotpitayasunondh b, Bernard Hirschel f, Jintanat Ananworanich a,g the HIV-NAT 013 Study Team a
The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Center, 104 Ratchadamri Road, Pathumwan, Bangkok 10330, Thailand Queen Sirikit National Institute of Child Health, Bangkok, Thailand c Vanderbilt University School of Medicine, TN, USA d Chulalongkorn University, Bangkok, Thailand e National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia f Geneva University, Geneva, Switzerland g South East Asia Research Collaboration with Hawaii (SEARCH), Bangkok, Thailand b
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Article history: Received 4 December 2008 Received in revised form 21 May 2009 Accepted 25 May 2009
Objective: To evaluate outcomes in dual nucleoside reverse transcriptase inhibitor (NRTI) pretreated children after genotyping (GT). Methods: We assessed CD4 and viral load (VL) in children three years after baseline GT at the time of dual NRTI failure. Baseline high grade resistance (HR) was defined as 4 nucleoside analogue mutations (NAMs) Q151 M or 69 insertion complex, and low grade resistance (LR) was defined as
