Jun 20, 2015 - intraperitoneal injection of 60 mg/kg STZ dissolved in 0.1 M sodium citrate buffer at pH 4.5. The rats had free access to 5% of glucose water and ...
ejbps, 2015, Volume 2, Issue 4,538-551.
Research Article
SJIF Impact Factor 2.062
European Journal of Biomedical AND Pharmaceutical sciences http://www.ejbps.com
ISSN 2349-8870 Volume: 2 Issue: 4 538-551 Year: 2015
ANTIDIABETIC, ANTIHYPERLIPIDAEMIC AND ANTIOXIDANT ACTIVITIES OF LEAVES OF LEUCAS LINIFOLIA SPRENG IN STREPTOZOTOCIN INDUCED DIABETIC RATS Dr. Mukundam Borah*1 and Dr. Swarnamoni Das2 1
Demonstrator (MD, Pharmacology), Department of Pharmacology, Gauhati Medical College & Hospital, Guwahati, Assam, PIN-781032. 2
Professor & Head, Department of Pharmacology, Assam Medical College and Hospital, Dibrugarh, Assam, PIN-786002.
Article Received on 09/06/2015
Article Revised on 20/06/2015
Article Accepted on 21/07/2015
ABSTRACT *Correspondence for
Objectives: The leaves of Leucas linifolia Spreng. are used in folk
Author Dr. Mukundam Borah
medicine to treat diabetes. The objective of the study was to evaluate
Demonstrator (MD,
the antidiabetic, anti-hyperlipidemic and anti-oxidant activities of the
Pharmacology), Department
ethanolic extract of the leaves of Leucas linifolia Spreng. (EELL) in
of Pharmacology, Gauhati
streptozotocin induced diabetic rats. Materials & Methods: Male
Medical College & Hospital,
Wistar albino rats (150–200g) were administered single intraperitoneal
Guwahati, Assam, PIN-
injection of STZ (60 mg/kg b.w. i.p) to induce diabetes. Albino rats
781032.
(n=25) were divided into five groups of five animals each. Group I (Normal control) and Group II (Diabetic control) received normal saline (10ml / kg / day p.o) whereas Group III and Group IV received 250 mg/kg/day and 500 mg/kg/day p.o of EELL respectively for two weeks. Group V (Diabetic standard) received 6 U/kg /day s.c of NPH insulin. Biochemical estimations of fasting blood sugar, serum insulin, catalase, malondialdehyde and serum lipid profile were performed on 1st, 8th and 15th day. Effect of EELL on intestinal glucose absorption was also evaluated. Results: Group II exhibited significant rise in blood glucose, serum cholesterol, triglycerides, Low density lipoprotein, serum malondialdehyde levels and decrease in serum insulin, catalase and High density lipoprotein levels. EELL treated groups showed reversal of these changes significantly (p
