Original Article
http://dx.doi.org/10.3349/ymj.2013.54.3.567 pISSN: 0513-5796, eISSN: 1976-2437
Yonsei Med J 54(3):567-571, 2013
Association between Cerebrospinal Fluid S100B Protein and Neuronal Damage in Patients with Central Nervous System Infections Jeong-Wook Park, Gyoung Im Suh, and Hae-Eun Shin Department of Neurology, The Catholic University of Korea College of Medicine, Uijeongbu St. Mary’s Hospital, Uijeongbu, Korea.
Received: January 26, 2012 Revised: April 25, 2012 Accepted: May 11, 2012 Corresponding author: Dr. Hae-Eun Shin, Department of Neurology, The Catholic University of Korea College of Medicine, Uijeongbu St. Mary’s Hospital, 271 Cheonbo-ro, Uijeongbu 480-717, Korea. Tel: 82-31-820-3986, Fax: 82-31-821-3662 E-mail:
[email protected] ∙ The authors have no financial conflicts of interest.
Purpose: S100B protein is widely used as a measure of glial activity or damage in several brain conditions. Central nervous system (CNS) infections can cause neurological sequelae because of parenchyma invasion. It is difficult to predict further neuronal damage in the CNS infection. The present study is aimed to evaluate the role of the cerebrospinal fluid (CSF) S100B protein as an indicator of neuronal damage in CNS infection. Materials and Methods: We measured the concentration of CSF S100B protein in 62 patients with a CNS infection using an EnzymeLinked Immunosorbent Assay. The patients with CNS infections were classified as having no neuronal damage (CNS-N) or as having neuronal damage (CNS+N) according to the presence of neurological change or structural lesions on brain MRI. Results: The CSF S100B protein level of the CNS+N group (n=22, 0.235 µg/L, 0.10-2.18) was significantly higher than that of the CNS-N group (n=40, 0.087 µg/ L, 0.06-0.12) and control group (n=40, 0.109 µg/L, 0.07-0.14, p
