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6 days ago - Results. The study population comprised 1.429 individuals (median age 56 (IQR 48–66) years, 40% males) with complete ECG, ...
RESEARCH ARTICLE

Association between echocardiographic parameters and biomarkers in probands with atrial fibrillation and different PR interval lengths: Insight from the epidemiologic LIFE Adult Study a1111111111 a1111111111 a1111111111 a1111111111 a1111111111

OPEN ACCESS Citation: Kornej J, Zeynalova S, Thiery J, Burkhardt R, Baber R, Engel C, et al. (2019) Association between echocardiographic parameters and biomarkers in probands with atrial fibrillation and different PR interval lengths: Insight from the epidemiologic LIFE Adult Study. PLoS ONE 14(2): e0212627. https://doi.org/10.1371/journal. pone.0212627 Editor: Elena Cavarretta, Universita degli Studi di Roma La Sapienza, ITALY Received: September 25, 2018

Jelena Kornej ID1,2,3☯*, Samira Zeynalova2,3☯, Joachim Thiery3,4, Ralph Burkhardt3,4, Ronny Baber3,4, Christoph Engel2,3, Andreas Hagendorff3,5‡, Markus Loeffler2,3‡, Daniela Husser1,3‡ 1 Department of Electrophysiology, Heart Center, Leipzig, Germany, 2 Institute for Medical Informatics, Statistics, and Epidemiology, University of Leipzig, Leipzig, Germany, 3 LIFE – Leipzig Research Center of Civilization Diseases, University of Leipzig, Leipzig, Germany, 4 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany, 5 Department of Cardiology, University of Leipzig, Leipzig, Germany ☯ These authors contributed equally to this work. ‡ These authors also contributed equally to this work. * [email protected]

Abstract Background PR interval prolongation is associated with increased risk for atrial fibrillation (AF). Different biomarkers are used to predict AF incidence and its outcomes. The aim of this study was to investigate the association between echocardiographic parameters and blood biomarkers in PR interval groups and AF.

Accepted: February 6, 2019 Published: February 28, 2019 Copyright: © 2019 Kornej et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper. Funding: This publication is supported by LIFE – Leipzig Research Center for Civilization Diseases, an organizational unit affiliated to the Medical Faculty of the University Leipzig. LIFE is funded by means of the EU, by the European Regional Development Fund (ERDF) and by funds of the Free State of Saxony within the framework of the

Methods The LIFE-Adult-Study is a population-based cohort study of randomly selected participants from Leipzig, Germany. In this cross-sectional analysis, individuals �40 years with available echocardiographic (LA diameter, EF) and laboratory data (creatinine, Troponin, NTproBNP) were included.

Results The study population comprised 1.429 individuals (median age 56 (IQR 48–66) years, 40% males) with complete ECG, echocardiographic and laboratory data. There were 48 (3.4%) individuals with AF, 177 (12.4%) with short, 138 (9.7%) with prolonged and 1.066 (74.5%) with normal PR interval. Individuals with PR interval prolongation had larger LA diameter, higher Troponin and NT-proBNP levels than individuals with normal PR interval, but lower than AF group (p