Baker Heart Research Institute - Baker IDI

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Apr 1, 2013 ... and cardiac fibrosis in the db/db mouse model of type 2 diabetes. .... Du XJ. Re- modelling 'hostile' milieu of diseased myocardium via paracrine function of ... Wei HM, Fang L, Song J, Chatterjee S. Statin-inhibited endothelial ...
Baker IDI Heart and Diabetes Institute Experimental Cardiology Laboratory Publications Journal Articles Rafehi H, Balcerczyk A, Lunke S, Kaspi A, Ziemann M, Kn H, Okabe J, Khurana I, Ooi J, Khan AW, Du XJ, Chang L, Haviv I, Keating ST, Karagiannis TC, El-Osta A. Vascular histone deacetylation by pharmacological HDAC inhibition. Genome Res 2014; in press. Moore XL, Su Y, Fan Y, Zhang YY, Woodcock EA, Dart AM, Du XJ. Diverse regulation of cardiac expression of relaxin receptor by α1- and β 1-adrenoceptors. Cardiovasc Drugs Ther 2014;28(3):221-8. Bernardo BC, Gao XM, Tham YK, Kiriazis H, Winbanks CE, Ooi JY, Boey EJ, Obad S, Kauppinen S, Gregorevic P, Du XJ, Lin RC, McMullen JR. Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy. PLoS One 2014;9(2):e90337. White DA, Su Y, Kanellakis P, Kiriazis H, Morand EF, Bucala R, Dart AM, Gao XM, Du XJ. Differential roles of cardiac and leukocyte derived macrophage migration inhibitory factor in inflammatory responses and cardiac remodelling post myocardial infarction. J Mol Cell Cardiol 2014;69:32-42. Mathiyalagan P, Okabe J, Chang L, Su Y, Du XJ, El-Osta A. The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart. Nucleic Acids Res 2014;42(2):790-803. Chan W, White DA, Wang XY, Bai RF, Liu Y, Yu HY, Zhang YY, Fan F, Schneider HG, Duffy SJ, Taylor AJ, Du XJ, Gao W, Gao XM, Dart AM. Macrophage migration inhibitory factor for the early prediction of infarct size. J Am Heart Assoc 2013;2(5):e000226. Rose H, Low H, Dewar E, Bukrinsky M, Hoy J, Dart A, Sviridov D. The effect of HIV infection on atherosclerosis and lipoprotein metabolism: a one year prospective study. Atherosclerosis 2013;229(1):206-11. Fang L, Beale A, Ellims AH, Moore XL, Ling LH, Taylor AJ, Chin-Dusting J, Dart AM. Associations between fibrocytes and postcontrast myocardial T1 times in hypertrophic cardiomyopathy. J Am Heart Assoc 2013;2(5):e000270. White DA, Fang L, Chan W, Morand EF, Kiriazis H, Duffy SJ, Taylor AJ, Dart AM, Du XJ, Gao XM. Pro-inflammatory action of MIF in acute myocardial infarction via activation of peripheral blood mononuclear cells. PLoS One 2013;8(10):e76206. Kiriazis H, Tugiono N, Xu Q, Gao XM, Jennings NL, Ming Z, Su Y, Klenowski P, Summers RJ, Kaumann A, Molenaar P, Du XJ. Chronic activation of the low affinity site of β1 adrenoceptors stimulates haemodynamics but exacerbated pressure-overload cardiac remodelling. Br J Pharmacol 2013;170(2):352-65. 1

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Huynh K, Kiriazis H, Du XJ, Love JE, Gray SP, Jandeleit-Dahm KA, McMullen JR, Ritchie RH. Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice. Free Radic Biol Med 2013;60:307-17. Lee YY, Moujalled D, Doerflinger M, Gangoda L, Weston R, Rahimi A, de Alboran I, Herold M, Bouillet P, Xu Q, Gao X, Du XJ, Puthalakath H. CREB-binding protein (CBP) regulates β-adrenoceptor (β-AR)-mediated apoptosis. Cell Death Differ 2013;20(7):941-52. Moore XL, Michell D, Lee S, Skilton MR, Nair R, Dixon JB, Dart AM, Chin-Dusting J. Increased carotid intima-media thickness and reduced distensibility in human class III obesity: independent and differential influences of adiposity and blood pressure on the vasculature. PLoS One 2013;8(1):e53972. Cooley N, Ouyang K, McMullen JR, Kiriazis H, Sheikh F, Wu W, Mu Y, Du XJ, Chen J, Woodcock EA. No contribution of IP3-R(2) to disease phenotype in models of dilated cardiomyopathy or pressure overload hypertrophy. Circ Heart Fail 2013;6(2):318-25. Weeks KL, Gao X, Du XJ, Boey EJ, Matsumoto A, Bernardo BC, Kiriazis H, Cemerlang N, Tan JW, Tham YK, Franke TF, Qian H, Bogoyevitch MA, Woodcock EA, Febbraio MA, Gregorevic P, McMullen JR. Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction. Circ Heart Fail 2012;5(4):523-34. Liu Y, Jennings NL, Dart AM, Du XJ. Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice. World J Exp Med 2012;2(2):30-6. Huynh K, Kiriazis H, Du XJ, Love JE, Jandeleit-Dahm KA, Forbes JM, McMullen JR, Ritchie RH. Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes. Diabetologia 2012;55(5):1544-53. Gu HP, Lin S, Xu M, Yu HY, Du XJ, Zhang YY, Yuan G, Gao W. Up-regulating relaxin expression by G-quadruplex interactive ligand to achieve antifibrotic action. Endocrinology 2012;153(8):3692-700. Tikellis C, Pickering R, Tsorotes D, Du XJ, Kiriazis H, Nguyen-Huu TP, Head GA, Cooper ME, Thomas MC. Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes. Clin Sci 2012;123(8):519-29. Ritchie RH, Love JE, Huynh K, Bernardo BC, Henstridge DC, Kiriazis H, Tham YK, Sapra G, Qin C, Cemerlang N, Boey EJ, Jandeleit-Dahm K, Du XJ, McMullen JR. Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes. Diabetologia 2012;55(12):3369-81. Chan W, Duffy SJ, White DA, Gao XM, Du XJ, Ellims AH, Dart AM, Taylor AJ. Acute left ventricular remodeling following myocardial infarction: coupling of regional healing with remote extracellular matrix expansion. JACC Cardiovasc Imaging 2012;5(9):884-93.

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Bernardo BC, Gao XM, Winbanks CE, Boey EJ, Tham YK, Kiriazis H, Gregorevic P, Obad S, Kauppinen S, Du XJ, Lin RC, McMullen JR. Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. Proc Natl Acad Sci USA 2012;109(43):17615-20. Kiriazis H, Jennings NL, Davern P, Lambert G, Su Y, Pang T, Du X, La Greca L, Head GA, Hannan AJ, Du XJ. Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington's disease. J Physiol 2012;590(Pt 2):5845-60. Chang L, Kiriazis H, Gao XM, Du XJ, El-Osta A. Cardiac genes show contextual SWI/SNF interactions with distinguishable gene activities. Epigenetics 2011;6(6):760-8. Du XJ, Shan L, Gao XM, Kiriazis H, Liu Y, Lobo A, Head GA, Dart AM. Role of intramural platelet thrombus in the pathogenesis of wall rupture and intra-ventricular thrombosis following acute myocardial infarction. Thromb Haemost 2011;105(2):356-64. Gao XM, Liu Y, White D, Su Y, Drew BG, Bruce CR, Kiriazis H, Xu Q, Jennings N, Bobik A, Febbraio MA, Kingwell BA, Bucala R, Fingerle-Rowson G, Dart AM, Morand EF, Du XJ. Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation. J Mol Cell Cardiol 2011;50(6):991-9. Xu Q, Dalic A, Fang L, Kiriazis H, Ritchie R, Sim K, Gao XM, Drummond G, Sarwar M, Zhang YY, Dart A, Du XJ. Myocardial oxidative stress contributes to transgenic β(2) adrenoceptor activation-induced cardiomyopathy and heart failure. Br J Pharmacol 2011;162(5):1012-28. Tu Y, Wu T, Dai A, Pham Y, Chew P, de Haan JB, Wang Y, Toh BH, Zhu H, Cao Z, Cooper ME, Chai Z. Cell division autoantigen 1 enhances signaling and the profibrotic effects of transforming growth factor-β in diabetic nephropathy. Kidney Int 2011;79(2):199209. Samuel CS, Cendrawan S, Gao XM, Ming Z, Zhao C, Kiriazis H, Xu Q, Tregear GW, Bathgate RA, Du XJ. Relaxin remodels fibrotic healing following myocardial infarction. Lab Invest 2011;91(5):675-90. Hossain MA, Man BC, Zhao C, Xu Q, Du XJ, Wade JD, Samuel CS. H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor. Biochemistry 2011;50(8):1368-75. Chu PY, Zatta A, Kiriazis H, Chin-Dusting J, Du XJ, Marshall T, Kaye DM. CXCR4 antagonism attenuates the cardiorenal consequences of mineralocorticoid excess. Circ Heart Fail 2011;4(5):651-8. Fang L, Du XJ, Gao XM, Dart AM. Activation of peripheral blood mononuclear cells and extracellular matrix and inflammatory gene profile in acute myocardial infarction. Clin Sci 2010;119(4):175-83.

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Ying SQ, Xiang MX, Fang L, Wang JA. Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention. J Zhejiang Univ Sci B 2010;11(8):575-82. Gao XM, Ming Z, Su Y, Fang L, Kiriazis H, Xu Q, Dart AM, Du XJ. Infarct size and postinfarct inflammation determine the risk of cardiac rupture in mice. Int J Cardiol 2010;143(1):20-8. Kanellakis P, Pomilio G, Agrotis A, Gao X, Du XJ, Curtis D, Bobik A. Darbepoetinmediated cardioprotection after myocardial infarction involves multiple mechanisms independent of erythropoietin receptor-common beta-chain heteroreceptor. Br J Pharmacol 2010;160(8):2085-96. Xiao H, Zhang YY, Du XJ, Lu ZZ. Developmental changes in the geometry, function and responsiveness of the mouse heart to beta-adrenergic stimulation as determined by highresolution echocardiography. Clin Exp Pharmacol Physiol 2010;37(8):826-32. Huynh K, McMullen JR, Julius TL, Tan JW, Love JE, Cemerlang N, Kiriazis H, Du XJ, Ritchie RH. Cardiac-specific IGF-1 receptor transgenic expression protects against cardiac fibrosis and diastolic dysfunction in a mouse model of diabetic cardiomyopathy. Diabetes 2010;59(6):1512-20. Mathiyalagan P, Chang L, Du XJ, El-Osta A. Cardiac ventricular chambers are epigenetically distinguishable. Cell Cycle 2010;9(3):612-7. Lin RC, Weeks KL, Gao XM, Williams RB, Bernardo BC, Kiriazis H, Matthews VB, Woodcock EA, Bouwman RD, Mollica JP, Speirs HJ, Dawes IW, Daly RJ, Shioi T, Izumo S, Febbraio MA, Du XJ, McMullen JR. PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA. Arterioscler Thromb Vasc Biol 2010;30(4):724-32. Xu Q, Chakravorty A, Bathgate RA, Dart AM, Du XJ. Relaxin therapy reverses large artery remodeling and improves arterial compliance in senescent spontaneously hypertensive rats. Hypertension 2010;55(5):1260-6. Mukhamedova N, Rose H, Cui HL, Grant A, Tchoua U, Dart A, Bukrinsky M, Sviridov D. Antiretroviral compounds and cholesterol efflux from macrophages. Atherosclerosis 2009;206(2):439-43. Du XJ, Xu Q, Lekgabe E, Gao XM, Kiriazis H, Moore XL, Dart AM, Tregear GW, Bathgate RA, Samuel CS. Reversal of cardiac fibrosis and related dysfunction by relaxin. Ann NY Acad Sci 2009;1160:287-84. Pretorius L, Du XJ, Woodcock EA, Kiriazis H, Lin RC, Marasco S, Medcalf RL, Ming Z, Head GA, Tan JW, Cemerlang N, Sadoshima J, Shioi T, Izumo S, Lukoshkova EV, Dart AM, Jennings GL, McMullen JR. Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation. Am J Pathol 2009;175(3):9981009. 4

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Woodcock EA, Grubb DR, Filtz TM, Marasco S, Luo J, McLeod-Dryden TJ, Kaye DM, Sadoshima J, Du XJ, Wong C, McMullen JR, Dart AM. Selective activation of the "b" splice variant of phospholipase Cbeta1 in chronically dilated human and mouse atria. J Mol Cell Cardiol 2009;47(5):676-83. Halls ML, Hewitson TD, Moore XL, Du XJ, Bathgate RA, Summers RJ. Relaxin activates multiple cAMP signaling pathway profiles in different target cells. Ann NY Acad Sci 2009;1160:108-11. Moore XL, Hong A, Du XJ. Alpha-adrenergic activation upregulates expression of relaxin receptor RXFP1 in cardiomyocytes. Ann NY Acad Sci 2009;1160:285-6. Meng S, Fang L, Wang CQ, Wang LS, Chen MT, Huang XH. Impact of obstructive sleep apnoea on clinical characteristics and outcomes in patients with acute coronary syndrome following percutaneous coronary intervention. J Int Med Res 2009;37(5):1343-53. Huynh NN, Andrews KL, Head GA, Khong SM, Mayorov DN, Murphy AJ, Lambert G, Kiriazis H, Xu Q, Du XJ, Chin-Dusting JP. Arginase II knockout mouse displays a hypertensive phenotype despite a decreased vasoconstrictory profile. Hypertension 2009;54(2):294-301. Xu Q, Lekgabe ED, Gao XM, Ming Z, Tregear GW, Dart AM, Bathgate RA, Samuel CS, Du XJ. Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis. Endocrinology 2008;149(2):476-82. Amirahmadi F, Turnbull L, Du XJ, Graham RM, Woodcock EA. Heightened alpha1Aadrenergic receptor activity suppresses ischaemia/reperfusion-induced Ins(1,4,5)P3 generation in the mouse heart: a comparison with ischaemic preconditioning. Clin Sci 2008;114(2):157-64. Woodcock EA, Du XJ, Reichelt ME, Graham RM. Cardiac alpha 1-adrenergic drive in pathological remodelling. Cardiovasc Res 2008;77(3):452-62. Kiriazis H, Wang K, Xu Q, Gao XM, Ming Z, Su Y, Moore XL, Lambert G, Gibbs ME, Dart AM, Du XJ. Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overloadinduced cardiac hypertrophy and fibrosis. Br J Pharmacol 2008;153(4):684-92. Fang L, Gao XM, Samuel CS, Su Y, Lim YL, Dart AM, Du XJ. Higher levels of collagen and facilitated healing protect against ventricular rupture following myocardial infarction. Clin Sci 2008;115(3):99-106. Drenckhahn JD, Schwarz QP, Gray S, Laskowski A, Kiriazis H, Ming Z, Harvey RP, Du XJ, Thorburn DR, Cox TC. Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development. Dev Cell 2008;15(4):521-33.

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Bathgate RA, Lekgabe ED, McGuane JT, Su Y, Pham T, Ferraro T, Layfield S, Hannan RD, Thomas WG, Samuel CS, Du XJ. Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis. Mol Cell Endocrinol 2008;280(1-2):30-8. Yang Y, Ma Y, Han W, Li J, Xiang Y, Liu F, Ma X, Zhang J, Fu Z, Su YD, Du XJ, Gao XM. Age-related differences in postinfarct left ventricular rupture and remodeling. Am J Physiol Heart Circ Physiol 2008;294(4):H1815-22. Moore XL, Tan SL, Lo CY, Fang L, Su YD, Gao XM, Woodcock EA, Summers RJ, Tregear GW, Bathgate RA, Du XJ. Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes. Endocrinology 2007;148(4):1582-9. Xu Q, Ming ZQ, Dart AM, Du XJ. Optimizing dosage of ketamine and xylazine in murine echocardiography. Clin Exp Pharmacol Physiol 2007;34(5-6):499-507. Fang L, Moore XL, Gao XM, Dart AM, Lim YL, Du XJ. Down-regulation of mitofusin-2 expression in cardiac hypertrophy in vitro and in vivo. Life Sci 2007;80(23):2154-60. Fang L, Gao XM, Moore XL, Kiriazis H, Su Y, Ming Z, Lim YL, Dart AM, Du XJ. Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction. J Mol Cell Cardiol 2007;43(5):53544. Du XJ. Re-modelling 'hostile' milieu of diseased myocardium via paracrine function of transplanted cells or relaxin. J Cell Mol Med 2007;11(5):1101-4. Jiang XY, Gao GD, Du XJ, Zhou J, Wang XF, Lin YX. The signalling of AT2 and the influence on the collagen metabolism of AT2 receptor in adult rat cardiac fibroblasts. Acta Cardiol 2007;62(5):429-38. Du XJ, Zhou J. Role of relaxin in heart disease and therapeutic potential. J Xian Jiaotong University (Med Sci) 2007;28:117-26. Xu Q, Xu N, Zhang T, Zhang H, Li Z, Yin F, Lu Z, Han Q, Zhang Y. Mammalian tolloid alters subcellular localization, internalization, and signaling of alpha(1a)-adrenergic receptors. Mol Pharmacol 2006;70(2):532-41. Lekgabe ED, Royce SG, Hewitson TD, Tang ML, Zhao C, Moore XL, Tregear GW, Bathgate RA, Du XJ, Samuel CS. The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of non-reproductive organs. Endocrinology 2006;147(12):5575-83. Du XJ, Gao XM, Kiriazis H, Moore XL, Ming Z, Su Y, Finch AM, Hannan RA, Dart AM, Graham RM. Transgenic alpha(1A)-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival. Cardiovasc Res 2006;71(4):735-43.

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Lu J, Moochhala S, Moore XL, Ng KC, Tan MH, Lee LK, He B, Wong MC, Ling EA. Adult bone marrow cells differentiate into neural phenotypes and improve functional recovery in rats following traumatic brain injury. Neurosci Lett 2006;398(1-2):12-7. Kanellakis P, Slater NJ, Du XJ, Bobik A, Curtis DJ. Granulocyte colony-stimulating factor and stem cell factor improve endogenous repair after myocardial infarction. Cardiovasc Res 2006;70(1):117-25. Gao XM, Wong G, Wang B, Kiriazis H, Moore XM, Su YD, Dart AM, Du XJ. Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis. J Hypertens 2006;24(8):1663-70. Samuel CS, Zhao C, Bathgate RA, Du XJ, Summers RJ, Amento EP, Walker LL, McBurnie M, Zhao L, Tregear GW. The relaxin gene-knockout mouse: a model of progressive fibrosis. Ann NY Acad Sci 2005;1041:173-181. Gao XM, Kiriazis H, Moore XL, Feng XH, Sheppard K, Dart A, Du XJ. Regression of pressure-overload induced left ventricular hypertrophy in mice. Am J Physiol Heart Circ Physiol 2005;288(6):2702-7. Wei HM, Fang L, Song J, Chatterjee S. Statin-inhibited endothelial permeability could be associated with its effect on PECAM-1 in endothelial cells. FEBS Lett 2005;579(5):1272-8. Fang L, Wei HM, Chowdhury SH, Gong NL, Song J, Xiong ZW, Mak KH, Wang D, Lim YL, Chatterjee S. Association of Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene & soluble level of PECAM-1 with coronary artery disease in Asian Indians. Indian J Med Res 2005;121(2):92-9. Mookerjee I, Unemori EN, Du XJ, Tregear GW, Samuel CS. Relaxin modulates fibroblast function, collagen production, and matrix metalloproteinase-2 expression by cardiac fibroblasts. Ann NY Acad Sci 2005;1041:190-3. Lekgabe ED, Kiriazis H, Zhao C, Xu Q, Moore XL, Su Y, Bathgate RA, Du XJ, Samuel CS. Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats. Hypertension 2005;46(2):412-8. Gao XM, Xu Q, Kiriazis H, Dart AM, Du XJ. Mouse model of post-infarct ventricular rupture: time course, strain- and gender-dependency, tensile strength, and histopathology. Cardiovasc Res 2005;65(2):469-77. Kiriazis H, Du XJ, Feng X, Hotchkin E, Marshall T, Finch S, Gao XM, Lambert G, Choate JK, Kaye DM. Preserved left ventricular structure and function in mice with cardiac sympathetic hyperinnervation. Am J Physiol Heart Circ Physiol 2005;289(4):H1359-65. Du XJ, Feng X, Gao XM, Tan TP, Kiriazis H, Dart AM. I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities. Br J Pharmacol 2004;142:107-12.

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Samuel CS, Unemori EN, Mookerjee I, Bathgate RA, Layfield SL, Mak J, Tregear, GW, Du XJ. Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo. Endocrinology 2004;145:4125-33. Du XJ, Fang L, Gao XM, Kiriazis H, Feng X, Hotchkin E, Finch AM, Chaulet H, Graham RM. Genetic enhancement of ventricular contractility protects against pressure-overloadinduced cardiac dysfunction. J Mol Cell Cardiol 2004;37:979-87. Fang L, Wei HM, Mak KH, Xiong ZW, Song J, Lim YL, Chatterjee S. Markers of low-grade inflammation and soluble cell adhesion molecules in Chinese patients with coronary artery disease. Can J Cardiol 2004;20:1433-8. Moore XL, Lu J, Sun L, Zhu CJ, Tan P, Wong MC. Endothelial progenitor cells' "homing" specificity to brain tumors. Gene Ther 2004;11:811-8. Kang KB, Wang TT, Woon CT, Cheah ST, Lim YK, Moore XL, Wong MC. Celecoxib enhances brain tumour cell radiosensitivity leading to massive tumour necrosis. Ann Acad Med Singap 2004;33:(Suppl):S19-20. Gao XM, Agrotis A, Autelitano DJ, Percy E, Woodcock EA, Jennings GL, Dart AM, Du XJ. Sex hormones and cardiomyopathic phenotype induced by cardiac beta2-adrenergic receptor overexpression. Endocrinology 2003;144:4097-105. Du XJ, Samuel CS, Gao XM, Zhao L, Parry LJ, Tregear GW. Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype. Cardiovasc Res 2003;57:395-404. Lu J, Moochhala S, Shirhan Md, Ng KC, Teo AL, Tan MH, Moore XL, Wong MC, Ling EA. Neuroprotection by aminoguanidine after lateral fluid-percussive brain injury in rats: a combined magnetic resonance imaging, histopathologic and functional study. Neuropharmacology 2003;44:253-63. Sato Y, Schmidt AG, Kiriazis H, Hoit BD, Kranias EG. Compensated hypertrophy of cardiac ventricles in aged transgenic FVB/N mice overexpressing calsequestrin. Mol Cell Biochem 2003;242:19-25. Schwarz B, Percy E, Gao XM, Dart AM, Richardt G, Du XJ. Altered calcium transient and development of hypertrophy in beta2-adrenoceptor overexpressing mice with and without pressure overload. Eur J Heart Fail 2003;5:131-6. Tan TP, Gao XM, Krawczyszyn M, Feng X, Kiriazis H, Dart AM, Du XJ. Assessment of cardiac function by echocardiography in conscious and anesthetized mice: importance of the autonomic nervous system and disease state. J Cardiovasc Pharmacol 2003;42:18290. Brandenburger Y, Arthur JF, Woodcock EA, Du XJ, Gao XM, Autelitano DJ, Rothblum LI, Hannan RD. Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF. FEBS Lett 2003;548:79-84. 8

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Du XJ, Cole TJ, Tenis N, Gao XM, Kontgen F, Kemp BE, Heierhorst J. Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice. Mol Cell Biol 2002;22:2821-9. Gao XM, Dilley RJ, Samuel CS, Percy E, Fullerton MJ, Dart AM, Du XJ. Lower risk of postinfarct rupture in mouse heart overexpressing beta 2-adrenergic receptors: importance of collagen content. J Cardiovasc Pharmacol 2002;40:632-40. Lambert E, Du XJ, Percy E, Lambert G. Cardiac response to norepinephrine and sympathetic nerve stimulation following experimental subarachnoid hemorrhage. J Neurol Sci 2002;198:43-50. Dart AM, Du XJ, Kingwell BA. Gender, sex hormones and autonomic nervous control of the cardiovascular system.. Cardiovasc Res 2002;53:678-87. Du XJ. Clues to understanding the role of estrogen receptors in mediating cardiovascular protection. Cardiovasc Res 2002;56:4-7. Woodcock EA, Wang BH, Arthur JF, Lennard A, Matkovich SJ, Du XJ, Brown JH, Hannan RD. Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor. J Biol Chem 2002;277:22734-42. Kiriazis H, Sato Y, Kadambi VJ, Schmidt AG, Gerst MJ, Hoit BD, Kranias EG. Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis. Cardiovasc Res 2002;53:372-81.

Reviews Du XJ, Hewitson TD, Nguyen M-N, Samuel CS. Therapeutic effects of serelaxin in acute heart failure: Necessity for bilateral research translation. Circ J 2014;78(3):542-52. Dayawansa NH, Gao XM, White DA, Dart AM, Du XJ. Role of MIF in myocardial ischaemia and infarction: insight from recent clinical and experimental findings. Clin Sci 2014;127(3):149-61. Mathiyalagan P, Keating ST, Du XJ, El-Osta A. Chromatin modifications remodel cardiac gene expression. Cardiovasc Res 2014;103(1):7-16. Du XJ, Hewitson TD, Nguyen MN, Samuel CS. Therapeutic effects of serelaxin in acute heart failure. Circ J 2014;78(3):542-52. Mathiyalagan P, Keating ST, Du XJ, El-Osta A. Interplay of chromatin modifications and non-coding RNAs in the heart. Epigenetics 2014;9(1):101-12. Du XJ. Findings from recent clinical studies on relaxin therapy of acute decompensated heart failure: translational implications. Chin J Front Med Sci 2013;5(10):15-20. Gao XM, White DA, Dart AM, Du XJ. Post-infarct cardiac rupture: recent insights on pathogenesis and therapeutic interventions. Pharmacol Ther 2012;134(2):156-79. 9

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Du XJ, Bathgate RA, Samuel CS, Dart AM, Summers RJ. Cardiovascular effects of relaxin: from basic science to clinical therapy. Nat Rev Cardiol 2010;7(1):48-58. Andrews KL, Moore XL, Chin-Dusting JP. Anti-atherogenic effects of high-density lipoprotein on nitric oxide synthesis in the endothelium. Clin Exp Pharmacol Physiol 2010;37(7):736-42. Du XJ. Distinct role of adrenoceptor subtypes in cardiac adaptation to chronic pressure overload. Clin Exp Pharmacol Physiol 2008;35(3):355-60. Du XJ. Divergence of hypertrophic growth and fetal gene profile: the influence of betablockers. Br J Pharmacol 2007;152(2):169-71. Samuel CS, Du XJ, Bathgate RA, Summers RJ. 'Relaxin' the stiffened heart and arteries: the therapeutic potential for relaxin in the treatment of cardiovascular disease. Pharmacol Ther 2006;112(2):529-52. Du XJ, Fang L, Kiriazis H. Sex dimorphism in cardiac pathophysiology: experimental findings, hormonal mechanisms, and molecular mechanisms. Pharmacol Ther 2006;111(2):434-75. Du XJ. Role of extracellular matrix in cardiac pathophysiology: recent findings from studies using mice. Chin J Pathophysiol 2004;20:2369-71. Du XJ. Gender modulates cardiac phenotype development in genetically modified mice. Cardiovasc Res 2004;63:510-9.

Other Du XJ, Kiriazis H. Pro-inflammatory role of platelets in hypertension-mediated end-organ damage: Editorial to: "Inhibition of platelet activation by clopidogrel prevents hypertensioninduced cardiac inflammation and fibrosis" by L.-X. Jia et al. Cardiovasc Drugs Ther 2013;27(6):485-7. Editorial. Du XJ, Kiriazis H, Dart AM. Arterial remodeling following pressure overload by aortic constriction: an overlooked and potentially fertile research area. Clin Exp Pharmacol Physiol 2011;38(9):559-61. Editorial. Wei HM, Fang L, Song J, Li GD, Chatterjee S. Lovastatin compromises C-reactive protein induced endothelial dysfunction including altered expression of cell adhesion molecules and increased monocyte recruitment. Atherosclerosis 2005;178(2):399-401. Letter.

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