Nephrol Dial Transplant (2006) 21: 2957–2958 doi:10.1093/ndt/gfl321 Advance Access publication 17 June 2006
Case Report
Bilateral uraemic optic neuritis complicating acute nephrocalcinosis Paul Manley1, Jennifer Somerfield2, Ian Simpson1, Alan Barber2 and Jonathan Zwi3 1
Department of Nephrology, 2Department of Neurology and 3Department of Pathology, Auckland City Hospital, Auckland, New Zealand
Keywords: acute renal failure; nephrocalcinosis; oral sodium phosphate solution; uraemic optic neuropathy; visual loss
Correspondence and offprint requests to: Dr Paul Manley, Department of Nephrology, Auckland City Hospital, Private Bag 92024, Auckland, New Zealand. Email:
[email protected]
Conflict of interest statement. None declared.
References 1. Winkelmayer WC, Eigner M, Berger O et al. Optic neuropathy in uremia: an interdisciplinary emergency. Am J Kidney Dis 2001; 37: E23 2. Markowitz GS, Nasr SH, Klein P et al. Renal failure due to acute nephrocalcinosis following oral sodium phosphate bowel cleansing. Hum Path 2004; 35: 675–684
ß The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email:
[email protected]
Downloaded from http://ndt.oxfordjournals.org/ by guest on June 7, 2013
Bilateral uraemic optic neuritis is a rare complication of acute renal failure characterized by subacute visual loss, often in the setting of undiagnosed renal disease [1]. Acute renal failure following oral sodium phosphate solution (OSPS), resulting in acute nephrocalcinosis, is being increasingly recognized [2–6]. We describe a patient presenting with visual loss in acute renal failure thought to be precipitated by bowel preparation with OSPS. An 85-year-old woman presented with subacute, progressive asymmetrical visual impairment. She denied headache, jaw claudication, myalgia or confusion. She had a 10-year history of hypertension and was prescribed a thiazide diuretic and an angiotensin-converting enzyme inhibitor (ACEi) for this. A colonoscopy, to investigate iron deficiency anaemia, had been performed using an OSPS preparation 6 days earlier. Examination revealed a blood pressure of 160/ 60 mmHg. Visual acuity was 6/48 in the left eye, and light perception only in the right eye. Mild optic-disc swelling on the right and superior-disc swelling on the left were present. Direct and consensual pupillary reflexes to light were present but sluggish. The remainder of the neurological examination was normal. Blood tests showed an elevated creatinine of 0.64 mmol/l (0.112 mmol/l 1 month earlier) and urea of 34 mmol/l. Adjusted calcium was 2.22 mmol/l and phosphate 2.36 mmol/l. Immunological and serological markers were normal. A bland sediment and insignificant proteinuria were noted on midstream urine examination. Ultrasound scan of the renal tract revealed moderately echogenic but normal-size kidneys. Renal biopsy demonstrated acute tubular
necrosis and widespread calcification. Tubular calcium phosphate deposition was confirmed with positive von Kossa staining. Magnetic resonance imaging of the brain showed T2 hyperintensity of the proximal optic nerves consistent with bilateral optic neuritis. A diagnosis of bilateral uraemic optic neuritis secondary to acute renal failure on the basis of acute nephrocalcinosis was made. She was managed without dialysis, and blood pressure control optimized. Steroid therapy was tapered over 3 months. Her creatinine fell and plateaued at 0.20 mmol/l. Her vision improved and on review at 3 months, her visual acuity was 6/24 þ 1 in the left eye, but light perception only in the right. Bilateral uraemic optic neuritis causes visual loss in the context of acute renal failure. Reported cases have typically presented with bilateral severe visual loss developing over days with oedematous optic discs. In the majority of cases, steroids, haemodialysis or a combination of both have been used with varied outcomes [1]. This case illustrates two important points. Firstly, subacute visual loss in the setting of renal failure may be caused by uraemic optic neuritis. Management of uraemic optic neuritis consists of dialysis and high-dose steroids. In the present case, conservative management of renal failure in conjunction with steroids resulted in an improvement in visual acuity. Secondly, patients with acute renal failure following OSPS may have acute nephrocalcinosis. An alternative agent to OSPS should be considered in the elderly with underlying renal impairment or in those on an ACEi, angiotensin receptor blocker or diuretic therapy to avoid this complication.
2958 3. Markowitz GS, Whelan J, D’Agati VD. Renal failure following bowel cleansing with a sodium phosphate purgative. Nephrol Dial Transplant 2005; 20: 850–851 4. Orias M, Mahnensmith R, Perazella M. Extreme hyperphosphatemia and acute renal failure after a phosphoruscontaining bowel regimen. Am J Nephrol 1999; 19: 60–63
P. Manley et al. 5. Ahmed M, Raval P, Buganza G. Oral sodium phosphate catharsis and acute renal failure. Am J Gastroenterol 1996; 91: 1261–1262 6. Desmeules S, Bergeron MJ, Isenring P. Acute phosphate nephropathy and renal failure. N Engl J Med 2003; 349: 1006–1007 Received for publication: 18.11.05 Accepted in revised form: 8.5.06
Downloaded from http://ndt.oxfordjournals.org/ by guest on June 7, 2013
