BIOLOGY 665: BIOCHEMISTRY II

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Lecturer: Fusao Takusagawa. 3004 Haworth, Tel 4-4727, [email protected]. Textbook: Fundamentals of Biochemistry, Voet, Voet, Pratt or. Biochemistry 3 rd.
BIOLOGY 638: BIOCHEMISTRY II Spring Semester 2016 Lecturer: Fusao Takusagawa 3004 Haworth, Tel 4-4727, [email protected] Textbook: Fundamentals of Biochemistry, Voet, Voet, Pratt or Biochemistry 3rd Edition, Voet & Voet or Any Advanced Biochemistry Textbook Web site: http://crystal.res.ku.edu

What is Biochemistry II? Biochemistry II focuses metabolism in living system. Metabolism is consisting of catabolism (bio-degradation) and anabolism (bio-synthesis). Organisms in any living system (such as animal, plant, fungus, or micro-organism) obtain energy from ATP hydrolysis and reducing power from NADPH. ATP and NADPH are produced by catabolism of carbohydrates, lipids, and proteins. On the other hand, carbohydrates, lipids, proteins, and nucleic acids (DNA and RNA) are synthesized from small molecules under anabolism processes using ATP hydrolysis energy. Living cells are constantly oxidized by catabolism and anabolism processes, and thus are necessary to reduce by using NADPH.

What can I expect to learn from this course? Catabolism and anabolism processes (i.e., chemical reactions) in living system are catalyzed by various enzymes, and the enzyme activities are precisely regulated by various mechanisms. Abnormally high or low enzyme activities result in serious diseases. In this course, you will obtain general knowledge of enzyme catalysis in very complicated chemical reactions (i.e., metabolisms of carbohydrates, lipids, proteins, and nucleic acids), and how the enzyme activities are regulated in order to maintain the proper levels of metabolites in living cells.

Lecture and Exam Schedule Lecture notes, study guides, and your exam scores are available at: http://crystal.res.ku.edu/, click Takusagawa’s Note, and select Biol 638 (Biochemistry II).

Date 1/20 1/27 2/1 2/8 2/10 2/17 2/24 3/2 3/4 3/9 3/123/21 3/28 4/1 4/8 4/11 4/15 4/18 4/22 4/29 5/4 5/5 5/11

Topic (No. lectures) Introduction to metabolism (3) Hormones and receptors (2) Glycolysis (3) EXAM-1 Glycogen metabolism (3) Citric acid cycle (3) Electron transport and oxidative phosphorylation (3) EXAM-2 Other pathways of carbohydrate metabolism (2) Photosynthesis (2) Spring Break (No classes) 3/12 – 3/20 Lipid metabolism (4) EXAM-3 Amino acid metabolism (3) Energy metabolism and integration (1) Nucleotide metabolism (2) DNA replication and repair (2.5) EXAM-4 Transcription (2.5) Translation (2) EXAM-5 Last day of class (No class) Final Exam (10:30 AM - 1:00 PM) at room 2023

Reading Assignment Chapter 13 Chapter 21b Chapter 14 Chapter 15 Chapter 16 Chapter 17 Chapter 14b Chapter 18 Chapter 19 Chapter 20 Chapter 21a Chapter 22 Chapter 24 Chapter 25 Chapter 26

Exams 1. Five regular exams and final exam are given in this course. 2. In addition to the regular exams, 16 short quizzes are given during or after each chapter. The quize-1 score is calculated on the basis of the first 8 quizzes and the quize-2 score is calculated on the basis of the second 8 quizzes. 3. No make-up exam or quiz is given. 4. The final exam is mandatory. 5. Early exam is given upon request. 6. Worst score among the five regular exams and eight quizzes in each half semester are excluded in the grade calculation. 7. One quiz in each half semester can be skipped if student attends a scientific meeting (Student must present a letter from the KU official organization). 8. Sample exams are available at: http://crystal.res.ku.edu/

Grade Regular five exams  25 points each --------------------- (125) Two quiz points  25 points each -------------------------- ( 50) Best 6 among the above 5 exams and 2 quizzes ----- 150 Final exam ------------------------------------------------------- 50 Total points ----------------------------------------------------- 200 About 1/10 of students will receive A, other about 1/2 of students will receive B+, B or B, and the other receive C, D, or F (No C+, C-, D+, or D-).

Office hours Mon – Fri 10:00 am - 4:00 pm (Please make appointment by e-mail)

Special requests Student who needs special requirement(s) for this course, please make appointment as soon as possible and describe your needs.

Academic misconduct Grade becomes F (No negotiation)