Biomedical applications of wild Antheraea mylitta silk sericin Nanoparticles. M. Sayed Iqbal Ahamad and Vootla Shyam Kumar*. Department of Biotechnology ...
Biomedical applications of wild Antheraea mylitta silk sericin Nanoparticles M. Sayed Iqbal Ahamad and Vootla Shyam Kumar* Department of Biotechnology and Microbiology, Karnatak University, Dharwad, India- 580003. Nature produces enormous biopolymers for specific application but only a part has been identified and the less is utilized. Silks are fibrous protein biopolymers spun by a variety of insect species including silkworms and spiders. Silk protein consists of two proteins, a fibrous, hydrophobic fibroin and hydrophilic sericin protein. Silk sericin is the gum like, hydrophilic protein surrounding the Fibroin in silk fibres, and is discarding during textile applications. In comparison to previous report on Bombyx mori silk sericin nanoparticle fabrication and biophysical characterization we have investigated synthesis and biophysical characterization of wild tasar sericin selfassembled, synthesized by diafiltration technique nanoparticles for biomedical applications. The natural biopolymeric nanoparticles from wild Antherae mylitta sericin are designed for sustained drug release, reduced drug toxicity, resulting in lesser frequency of dose administration. We expect that the wild silkworm sericin could be a new candidate polymer in biomedical application. Bioactive molecules can be attached to sericin by covalent bonding in order to form the bioconjugate. The sericin nanoparticles will be applied to cosmetic application for protecting active ingredients like retinol and also for targeted drug delivery.
