Biomimetic design

Introduc)on to Professors Update: 2017/11/10

醫學⼯工程學院 College of Biomedical Engineering

Affilia)on list Abbrevia)on

Full name

SBME

School of Biomedical Engineering

GIBMTE

Graduate InsAtute of Biomedical Materials and Tissue Engineering

GINME

Graduate InsAtute of Nanomedicine and Medical Engineering

GIBOM

Graduate InsAtute of Biomedical Optomechatronics

IPBME*

InternaAonal Ph.D. Program in Biomedical Engineering

*All professors belong to IPBME.

College of Biomedical Engineering

Contact informa)on Name

Affilia)on E-‐mail address

Name

Affilia)on E-‐mail address

Chih-‐Hwa Chen

[email protected]

Er-‐Yuan Chuang

Hsiang-‐Ho Chen

[email protected]

Wei-‐Chen Huang

Chih-‐Wei Peng

[email protected]

Jen-‐Chang Yang

[email protected]

[email protected]

TsungRong Kuo

[email protected]

Hua-‐Shan Liu

[email protected]

Yi-‐Ping Chen

Jian-‐Chiun Liou

[email protected]

Si-‐Han Wu

[email protected]

Yin-‐Ju Chen

[email protected]

Peng-‐Yuan Wang

[email protected]

Thierry Burnouf

[email protected]

Haw-‐Ming Huang

[email protected]

Der-‐Zen Liu

[email protected]

Tzu-‐Sen Yang

[email protected]

[email protected]

Li-‐Chern Pan

Ching-‐Li Tseng

[email protected]

Shao-‐Sian Li

[email protected]

Long-‐Sheng Lu

[email protected]

Hui-‐Hsin Hsiao

[email protected]

Yu-‐Jui Fan

Chien-‐Chung Chen

SBME

GIBMTE

[email protected] GIBMTE

GINME

GIBOM

[email protected]

[email protected]

[email protected]


SBME

Research Focus

‒  Biomaterials in Orthopedics ‒  Tissue engineering ‒  Sports medicine

Chih-Hwa Chen, MD

‒  Bone / Joint research ‒  Biomedical device

3-‐D cell sheets for tendon-‐to-‐bone healing of ACL reconstruc)on Thermosensi)ve hydrogel for tendon-‐to-‐bone healing of ACL reconstruc)on ACL graF fixa)on device TGF-‐ β 1 to modify collagen I scaffolds and synovial fluid stem cells for car)lage regenera)on •  PRP and alginate encapsulated synovial fluid stem cells for ACL par)al tear •  Novel bone subs)tute •  •  •  • 

College of Biomedical Engineering SBME

‒  Biomechanics ‒  Ergonomics ‒  Biomimetic design

Research Focus Hsiang-Ho Chen, PhD

•  Finite element to inves)gate brain responses to soccer-‐heading impacts •  Biomechanical comparison of axial load between cannulated locking screws and noncannulated cor)cal locking screws •  Bone remodeling characteris)cs of a short-‐stemmed total hip replacement •  Ultrastructure of anterior cruciate ligament graF by atomic force microscopy •  monitor the changes of viscoelas)c proper)es at bone-‐implant interface via resonance frequency analysis

1 3 1 3

2

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Research Focus Chih-Wei Peng, PhD

‒  Assistive technology ‒  Rehabilitation engineering ‒  Neural engineering

My research employs engineering approaches to understand and develop neuro-‐ modulaAon approaches to restore funcAon to neurological paAents. Current projects include: l  Novel transcranial direct current sAmulator (t-‐DCS) system for neural rehabilitaAon. l  Advanced neuromodulaAon approaches to treat bladder funcAons l  Weight-‐drop-‐induced traumaAc brain injury (TBI) animal model l  Intelligent drop foot sAmulator with real-‐Ame adapAve feedback control to enhance the walking ability in stroke. l  Understanding the mechanisms of and developing advanced approaches of deep brain sAmulaAon to treat bladder disorders. Deep Brain Stimulation

t-DCS system

Poten)al Spin-‐Off Company

Traumatic Brain Injury model


Research Focus Yu-Jui Fan, PhD

‒  ‒  ‒  ‒ 

MEMS Optofluidics Biosensors Cell mechanics

Developing microfluidic devices using unique physics, microenvironment control, and the poten)al for automa)on associated with miniaturized system for applica)ons in basic biology, medical diagnos)cs, and cell/)ssue engineering. •  High throughput, parallel, and mul)-‐color microflow cytometer. •  Concentrator integrated slit-‐based Surface Plasmon Resonance sensor •  Vessel mimicking microfluidic system

1 to 32 channels Filter Ball lens array


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Research Focus

Medical Imaging Advanced MR imaging and spectroscopic techniques

Hua-Shan Liu, PhD

•  MR perfusion-weighted imaging using arterial spin labeled (ASL) MRI •  MR quantitative-susceptibility mapping (QSM) technique •  MR spectroscopic technique in detection of 2-hydroxyglutarate (2-HG) in brain tumors •  MR functional and structural connectivity data analyses QSM

ASL

MR Spectroscopy

2-‐HG


Research Focus

‒  ASIC design for medical ‒  DNA sequence addressing ‒  Nano/micro bio-sensing

Jian-Chiun Liou, PhD

‒  Vascular monitoring/ ECG ‒  Human-machine interaction

•  Next-‐genera)on Intelligence an applica)on-‐specific integrated circuit(ASIC) design for medical DNA sequence genes addressing system •  Clinical vascular monitoring / ECG medical integrated wireless transmission system patch in clinical outcome studies predict chronic hemodialysis pa)ents •  Nano-‐micro sensing heart rate EMG pla]orm integra)on of human-‐machine interac)on control system •  Medical electronic ultrasonic photoelectric imaging system chip technology


Research Focus Yin-Ju Chen, PhD

‒  Tumor biology ‒  Therapeutic drugs and biomarkers ‒  Personalized medicine

•  Systemic approach to iden)fy cancer associated genes. •  Expansion and characteriza)on of circula)ng tumor cells (CTCs) for personalized cancer drug screening pla]orm •  Integrated cancer gene signature and drug database to find poten)al drugs to improve therapeu)c efficacy.


GIBMTE

Research Focus Thierry Burnouf, PhD

‒  Blood biomaterials ‒  Platelets micro/nanovesicles ‒  platelet growth factors in regenerative medicine & ex vivo cell expansion

•  Platelet growth factors prepara)ons for regenera)ve medicine (neurodegenera)on; wound healing) and cell therapy (ex vivo cell expansion for transplanta)on). •  Blood cells and blood cell-‐derived microvesicles drug-‐delivery systems •  Bioprocessing for purifica)on/virus inac)va)on of protein therapeu)cs and protein supplements for stem cell in vitro expansion.


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Research Focus Der-Zen Liu, PhD, Professor

‒  Nano- and microparticle design and synthesis ‒  Drug and antigen delivery system ‒  Cancer vaccine

•  Surface-modification of liposomes for antigen delivery •  Mucosal delivery routes for optimal immunization (e.g. oral, nasal, or ocular) •  Targeted-liposome platform for cancer vaccine applications


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Research Focus Chien-Chung Chen, PhD

‒  Tissue engineering ‒  Polymeric medical device design and fabrication ‒  Electrospinning Spin-‐Out Company

•  Electrospinning of novel microtube array membranes (MTAMs) •  Drug screening pla]orm and can achieve fast transla)on for R&D of an)-‐ cancer drugs •  MTAM pla]orm for encapsulated cell technology •  Microtube applica)on in regenera)ve medicine and biological separa)on


Research Focus

‒  ‒  ‒  ‒ 

Biomaterials Nanomedicine Nanoparticle Targeted therapy

Ching-Li Tseng, PhD Development of nanomaterials for medical applica)ons. l  Innova)ve and mul)func)onal nanocomposites for efficient drug or gene delivery system l  Nanocarriers to treat ocular diseases l  Nanopar)cles delivery to target )ssue and organ (lung-‐inhala)on) l 

TEM/DLS

Eye drops contained NPs

Nanomedicine for Inhalation Delivery Inhalation

Ocular retention In vitro targeting/ SPR result

Corneal neovascularization inhibition

Diagnosis

In vivo test

MRI

Dye solution

CT GEH particles flow

GEH-RGD particles flow

GEH-RGD dye

Therapy

Necrosis/apoptosis


Research Focus Long-Sheng Lu, MD, PhD

‒  Radiation oncology ‒  Tumor microenvironment ‒  Mitochondrial biology

Ioniza)on radia)on alters tumor-‐host interac)on via non-‐autonomous mechanisms l  Use of cell microscopy, image cytometry, molecular biology, explant culture, and murine models to explore the non-‐canonical effects of ionizing radia)on l  Strategies for normal organ protec)on and an)cancer immunity in the se`ngs of metasta)c breast and colorectal cancers. l  Non-‐destruc)ve func)onal assays with circula)ng tumor cells for cancer theranos)cs l  Novel applica)ons of 3D prin)ng in clinical radia)on oncology l 


Research Focus

‒  Nano-Biomaterials ‒  Oral route drug delivery ‒  Cancer drug delivery

Er-Yuan Chuang, PhD

•  Func)onal carrier systems for drug delivery in cancer and diseases, and for non-‐invasive photothermal an)cancer therapy •  Nano-‐biomaterial for )ssue engineering


Research Focus ‒  Biomedical materials Research Focus ‒  Brain-machine interfaces ‒  Implanted bioelectronics

Wei-Chen Huang, PhD l  l  l  l  l 

Fusion of human-‐machine interface Developing smart ultra-‐compliant bioelectronics Materials synthesis for func)onalizing brain-‐machine interfaces Synthesize s)muli-‐responsive polymer-‐based materials applied for ultra-‐compliant implants/bioelectronics Fabrica)on process design specific for developing devices composed of hydrated materials and electronic microstructures S3muli-‐responsive biomaterials

Biocompa3ble fabrica3on

Ultracompliant bioelectronics


GINME

Research Focus Jen-Chang Yang, PhD

-  Polymer engineering -  Electrospinning -  Biomimetic materials

•  Accelerate endodon)c treatment and develop amorphous metal salts for facilita)ng the handling property of Portland cements and dental applica)ons • 

Super Strong Silk Fibers

• 

Preventive Dentistry

•  Novel Root Canal Filling Materials

Caries Balance n

tio

Protective Factors •Saliva and Sealants •Antimicrobials •Fluoride •Effective Diet

liza era min Re Ca2+

Pathological Factors • Bacteria • Absence of Saliva • Dietary Metabolite

Caries Ca2+

Health

Demin

ation

eraliz


Research Focus

‒  Nanoscale therapeutics and diagnostics ‒  Nanotoxicity

Yi-Ping Chen, PhD

Developed biocompa)ble and therapeu)c MSM applied in medicine l  Inves)gated enzyme replacement therapy (ERT) using MSN-‐based protein delivery strategies l  Designed MSN as a smart an)body-‐targe)ng nanopar)cle to block nuclear transloca)on of the ac)vated NF-‐κB p65 for cancer therapy l  Conjugated biological pep)des onto MSN, which enhanced tumor targe)ng, intracellular uptake, and lysosomal targe)ng l 


Research Focus Tsung-Rong Kuo , PhD

‒  ‒  ‒  ‒ 

Disease biomarker detection Imaging contrast agent Hydrogen evolution reaction Nanomaterials syntheses

•  Development of rapid, reliable and sensi)ve pla]orm to detect disease biomarkers based on surface-‐enhanced Raman spectroscopy. •  Biocompa)ble nanomaterials for molecular imaging contrast agents •  Earth-‐abundant materials for hydrogen evolu)on reac)on


Research Focus Si-Han Wu, PhD

‒  ‒  ‒  ‒  ‒ 

Nano biotechnology Surface chemistry Porous materials Drug delivery Hybrid Silica Nanoparticles

•  Inves)ga)on of the synthe)c iden)ty of silica NP on biological and physiological responses in cells, zebrafish, and mice. •  Development of compartmentalized NP for encapsula)ng both hydrophobic and hydrophilic molecules. •  Development of highly dispersed silica NP in physiological media for tumor targe)ng.


Research Focus Peng-Yuan Wang, PhD

‒  ‒  ‒  ‒  ‒ 

Nanofabrication Colloidal lithography Biointerfaces Stem cells iPSCs

Modulate stem cell behaviour using surface nanotopography and chemistry l  Fabricate new surface nanopaderns using nanofabrica)on technologies l  Mimic stem cell niche to study complex stem cell microenvironment l  Develop new cell culture tools and scaffolds for regenera)ve medicine l  Explore cell signalling using molecular biology approaches l 

Nanofabrication

Stem cells


GIBOM

Research Focus Haw-Ming Huang, PhD l  l  l  l  l  l 

l 

‒  Biomechanics ‒  Biophysics ‒  Medical electronics

A novel radiopaque, biodegradable, and 3D printable bone screw was fabricated for the first time. SMF pretreatment before LPS challenge improved body temperature controlled capability and reduced tissue damage. SMF coupled with a DMSO-free freezing medium increased the survival rates of frozen–thawed dental pulp stem cells. SMF coupled with the slow cooling procedure increased survival rates of frozen-thawed erythrocytes without any negative effects The proliferation of DPSCs enhanced by the SMF is considered as a model of the p38 MAPK signalling pathway and intracellular calcium ion activation. The molecular mechanisms occurring after the implantation of human dentin powder is related to the IL1RN-CCL2 mediated signaling pathway. Damping factor analysis can be used as a supplementary tool to evaluate the healing process of osseointegration.


Research Focus Tzu-Sen Yang, PhD

‒  Biophotonics ‒  Single-cell biomechanics ‒  Bionanotechnology

•  Single-‐cell NF-‐kB dynamics for modeling TNF-‐α signaling circuits •  High spa)al-‐resolu)on single cell array and 3D cell bioprin)ng •  Mechanical proper)es and biocompa)bility of Ti-‐6Al-‐4V produced by selec)ve laser mel)ng •  Ac)on mechanism of nanopar)cle-‐mediated photothermal therapy on intracellular killing of Staphylococcus aureus QD-‐EGF-‐EGFR


Research Focus

‒  BioMEMS ‒  Bio Sensor ‒  Reproduction Medicine

Li-Chern Pan, Ph.D

‒  Rare Cell Sorting ‒  Biomedical device

•  •  •  •  • 

High Throughput Sorter for Progressive Mo)le Sperms from Raw Semen FDA Biocompa)bility Accessibility for Microfluidic Devices Method for Auto-‐adhere Capture and Analysis of Circula)on Tumor Cells Non-‐centrifugal removal Method for Low Damage Blood Sample Purifica)on Design Microfluidic automa)c dispenser and diagnosis system


Research Focus

‒  2 dimensional materials ‒  Photocarrier dynamics ‒  Biomedical device

Shao-Sian Li, Ph. D

‒  Surface modification ‒  Energy conversion

•  High quality 2-‐dimensional materials for biomedical sensors and biomedical appliance. •  Growth of carbon-‐based 2D materials with large area. •  Fabrica)on of atomically thin film by solu)on process. •  Novel 2D materials for biomedical sensor and other optoelectronics, like energy conversion devices. •  Surface modifica)on of medical appliance to improve the biomedical proper)es. n = 1 n = 2 n = 3

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N o rm a liz e d In te n s ity (a .u .)

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500

550

600

650

Wavelen g th (n m )


700

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Research Focus Hui-Hsin Hsiao, PhD •  •  •  • 

‒  ‒  ‒  ‒ 

FDTD method Plasmonics Metasurfaces Bio-optoelectronic devices

Linear and Nonlinear Plasmonics Metamaterials and Metasurfaces Op)cal and Electrical Modeling of Optoelectronic Devices: Light Emi`ng Diodes, Photovoltaics, Lasers, etc. Quantum Op)cs for Plasmonics and Metasurfaces

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