USA; 4Behavioral Health Center and Department of Child and Adolescent Psychiatry, The Children's ... report from a pediatric cohort in the Avon Longitudinal Study .... set for SNPs with call rates
brief reports
nature publishing group
Genetics
BMD-Associated Variation at the Osterix Locus Is Correlated With Childhood Obesity in Females Jianhua Zhao1, Jonathan P. Bradfield2, Mingyao Li3, Haitao Zhang2, Frank D. Mentch2, Kai Wang2, Patrick M.A. Sleiman2, Cecilia E. Kim2, Joseph T. Glessner2, Edward C. Frackelton2, Rosetta M. Chiavacci2, Robert I. Berkowitz4,5, Babette S. Zemel6,7, Hakon Hakonarson1,2,6 and Struan F.A. Grant1,2,6 Recent genome wide association studies (GWAS) have revealed a number of genetic variants robustly associated with bone mineral density (BMD) and/or osteoporosis. Evidence from epidemiological and clinical studies has shown an association between BMD and BMI, presumably as a consequence of bone loading. We investigated the 23 previously published BMD GWAS-derived loci in the context of childhood obesity by leveraging our existing genomewide genotyped European American cohort of 1,106 obese children (BMI ≥95th percentile) and 5,997 controls (BMI 3 or
