BRAF and NRAS Mutations in Papillary Thyroid Carcinoma and ...

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Concordance between mutations in the primary papillary thyroid carcinoma (PTC) and the paired x lymph node metastasis may elucidate the potential role of ...

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Received: 25 January 2017 Accepted: 23 May 2017 Published: xx xx xxxx

BRAF and NRAS Mutations in Papillary Thyroid Carcinoma and Concordance in BRAF Mutations Between Primary and Corresponding Lymph Node Metastases Najla Fakhruddin1,2, Mark Jabbour1, Michael Novy3, Hani Tamim4, Hisham Bahmad   5, Fadi Farhat6, Ghazi Zaatari1, Tarek Aridi7, Gernot Kriegshauser3, Christian Oberkanins3 & Rami Mahfouz1 Concordance between mutations in the primary papillary thyroid carcinoma (PTC) and the paired x lymph node metastasis may elucidate the potential role of molecular targeted therapy in advanced stages. BRAF and NRAS mutations in primary PTC (n = 253) with corresponding metastatic lymph node (n = 46) were analyzed utilizing StripAssays (ViennaLab Diagnostics). Statistical analysis was performed using (SPSS, Inc.), version 24.0 with a p-value of

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