Central IKK inhibition prevents air pollution mediated ... - Deep Blue

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Liu et al. Particle and Fibre Toxicology 2014, 11:53 http://www.particleandfibretoxicology.com/content/11/1/53

RESEARCH

Open Access

Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes Cuiqing Liu1,2†, Laura K Fonken2†, Aixia Wang2, Andrei Maiseyeu3, Yuntao Bai2, Tse-Yao Wang2, Santosh Maurya2, Yi-An Ko4, Muthu Periasamy2, Timothy Dvonch5, Masako Morishita5, Robert D Brook5, Jack Harkema6, Zhekang Ying3, Bhramar Mukherjee4, Qinghua Sun2, Randy J Nelson2 and Sanjay Rajagopalan3*

Abstract Background: Prior experimental and epidemiologic data support a link between exposure to fine ambient particulate matter (