Gray matter atrophy in prodromal and nonprodromal dementia with Lewy bodies and Alzheimer’s disease: a VBM-DARTEL study D. Roquet1, V. Noblet1, J-P. Armspach1, F. Blanc1,2 1
ICube, University of Strasbourg - CNRS, Strasbourg, France 2 Geriatrics and Neurology department, CMRR, University Hospital of Strasbourg, France contact:
[email protected]
Introduction •
Dementia with Lewy bodies (DLB) represents from 10 to 20 % of patients with dementia
•
Diagnosis of DLB lacks sensitivity and specificity but neuroimaging might provide relevant features for early diagnosis
•
Morphometric analyses revealed gray matter atrophy of insula in non-prodromal DLB but no study focused on prodromal DLB
•
Aim: evaluation and comparison of atrophy in DLB and AD prodromal (i.e., MCI) and mild dementia stages
Material and methods •
Participants:
•
Sequence: T1-weighted 3D MPRAGE MRI sequence
•
Processing: tissue segmentation (‘New segment’, SPM8), normalization to MNI-space (DARTEL), voxel-wise statistical
pro-DLB mild-DLB pro-AD mild-AD Controls (HC) Participants 54 15 16 28 22 Female 31 7 5 19 12 Age, years (SD) 69.3 (8.9) 74.3 (10.4) 75.3 (9.2) 74.1 (8.8) 65.5 (9.2) MMSE (SD) 27.6 (1.4) 20.7 (3.4) 27.1 (1.4) 19.3 (3.3) 29.0 (1.0)
parametric mapping of gray matter volume (SPM8, ANOVA, corrected for age, gender and total intracranial volume) at p