The Journal of Maternal-Fetal & Neonatal Medicine
ISSN: 1476-7058 (Print) 1476-4954 (Online) Journal homepage: http://www.tandfonline.com/loi/ijmf20
Cervical pessary for preventing preterm birth in twin pregnancies with short cervical length: a systematic review and meta-analysis Gabriele Saccone MD, Andrea Ciardulli, Serena Xodo MD, Lorraine Dugoff MD, Jack Ludmir MD, Francesco D’Antonio MD, PhD, Simona Boito MD, Elena Olearo MD, Carmela Votino MD, Giuseppe Maria Maruotti MD, Giuseppe Rizzo MD, Pasquale Martinelli MD & Vincenzo Berghella MD To cite this article: Gabriele Saccone MD, Andrea Ciardulli, Serena Xodo MD, Lorraine Dugoff MD, Jack Ludmir MD, Francesco D’Antonio MD, PhD, Simona Boito MD, Elena Olearo MD, Carmela Votino MD, Giuseppe Maria Maruotti MD, Giuseppe Rizzo MD, Pasquale Martinelli MD & Vincenzo Berghella MD (2016): Cervical pessary for preventing preterm birth in twin pregnancies with short cervical length: a systematic review and meta-analysis, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2016.1268595 To link to this article: http://dx.doi.org/10.1080/14767058.2016.1268595
Accepted author version posted online: 05 Dec 2016.
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Date: 08 December 2016, At: 14:17
Cervical pessary for preventing preterm birth in twin pregnancies with short cervical length: a systematic review and meta-analysis Gabriele Saccone MD,1,2 Andrea Ciardulli,3 Serena Xodo MD,4 Lorraine Dugoff MD,5 Jack Ludmir MD,6 Francesco D’Antonio MD, PhD,2,7 Simona Boito MD,2,8 Elena Olearo MD,2,9 Carmela Votino MD,2,10 Giuseppe Maria Maruotti MD,1,2 Giuseppe Rizzo MD,2,11 Pasquale Martinelli MD,1,2 Vincenzo Berghella MD.12 Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine,
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University of Naples Federico II, Naples, Italy
Italian Society of Ultrasound in Obstetrics and Gynecology (SIEOG)
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Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, Rome, Italy
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Department of Gynaecology and Obstetrics, School of Medicine, University of Udine, Udine,
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2
5
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Italy
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine and
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PA, USA
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Reproductive Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia,
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Perelman
School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 7
Fetal Medicine and Cardiology Unit, Department of Obstetrics and Gynecology, University
Hospital of Northern Norway. Perinatology Research group, Department of Clinical Medicine, University of Tromso, Norway
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Department of Obstetrics and Gynecology, L. Mangiagalli Fondazione IRCCS Ca’Granada,
Ospedale Maggiore Policlinico, Milan, Italy 9
Department of Surgical Sciences, University of Turin, Turin, Italy
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Department of Experimental and Clinical Medicine, Division of Obstetrics and Gynaecology,
Magna Graecia University of Catanzaro, Catanzaro, Italy Department of Obstetrics and Gynecology, Università Roma Tor Vergata, Rome, Italy
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Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Sidney
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Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA
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Correspondence: Vincenzo Berghella, MD, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Thomas Jefferson University, 833 Chestnut, Philadelphia, PA
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19107, USA. E-mail:
[email protected] Disclosure: The authors report no conflict of interest
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Financial Support: No financial support was received for this study
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Short title: Pessary in twins with short cervix
ABSTRACT Objective: To evaluate the effectiveness of cervical pessary for preventing spontaneous preterm birth (SPTB) in twin pregnancies with an asymptomatic transvaginal ultrasound cervical length (TVU CL) in the second trimester Methods: We performed a meta-analysis including all randomized clinical trials (RCTs) comparing the use of cervical pessary (i.e. intervention group) with expectant management (i.e.
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control group). The primary outcome was incidence of SPTB
