CGM

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Medtronic Enlite sensor was noticeably less accurate than the Dexcom G4P ... (DG4P) and the Medtronic (Northridge, CA) Paradigm Veo Enlite system (ENL).
Accuracy of two Continuous Glucose Monitoring (CGM) systems; a direct comparison in clinical research centre and daily life conditions Jort Kropff, MD1, Daniela Bruttomesso, PhD2, Werner Doll, MSc3, Anne Farret, PhD4, Silvia Galasso, MD 2, Yoeri M. Luijf, PhD1, Julia K. Mader, MD3, Jerome Place, MSc4, Federico Boscari, MSc2, Thomas R. Pieber, MD3, Eric Renard, PhD4, J. Hans DeVries, PhD1 −

1

Department of Internal Medicine, Academic Medical Center, University of Amsterdam,

Amsterdam, The Netherlands. −

2

Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy.



3

Department of Internal Medicine, Medical University Graz, Graz, Austria.



4

Department of Endocrinology, Diabetes, Nutrition and INSERM Clinical Investigation

Centre 1411, Montpellier University Hospital; Institute of Functional Genomics, CNRS UMR 5203, INSERM U661, University of Montpellier 1, Montpellier, France

Corresponding author: J. Kropff, MD, MSc, Academic Medical Center, Department of Internal Medicine, Room F4-215, PO Box 22660, 1100DD, Amsterdam, The Netherlands; email address [email protected], Fax: +3120-5669158 telephone: +31(0)20-5668332 ClinicalTrials.gov Identifier: NCT01751932

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/dom.12378

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Aims: This study assessed the accuracy and reliability of the two most widely used continuous glucose monitoring (CGM) systems. Materials and Methods: We studied the Dexcom®G4 Platinum (DG4P) and Medtronic®Enlite (ENL) CGMs, in 24 patients with type 1 diabetes. CGMs were tested during six day home use and a nested six hour clinical research centre (CRC) visit. During the CRC visit, frequent venous blood glucose samples were used as reference while patients received a meal with an increased insulin bolus to induce an aggravated postprandial glucose nadir. At home, patients performed at least six reference capillary blood measurements per day. Wilcoxon signed-rank test was performed using all data points ≥15 minutes apart. Results: Overall Mean Absolute Relative Difference (MARD) (SD) measured at the CRC was 13.6% (11.0) for DG4P and 16.6% (13.5) for ENL (p