nutrients Article
Changes in Plasma Acylcarnitine and Lysophosphatidylcholine Levels Following a High-Fructose Diet: A Targeted Metabolomics Study in Healthy Women Anita Gonzalez-Granda, Antje Damms-Machado, Maryam Basrai and Stephan C. Bischoff * Institute of Clinical Nutrition, University of Hohenheim, Fruwirthstr 12, 70599 Stuttgart, Germany;
[email protected] (A.G.-G.);
[email protected] (A.D.-M.);
[email protected] (M.B.) * Correspondence:
[email protected]; Tel.: +49-711-459-24101 Received: 23 July 2018; Accepted: 30 August 2018; Published: 6 September 2018
Abstract: Background: The consumption of high amounts of fructose is associated with metabolic diseases. However, the underlying mechanisms are largely unknown. Objective: To determine the effects of high fructose intake on plasma metabolomics. Study design: We enrolled 12 healthy volunteers (six lean and six obese women, age 24–35 years) in a crossover intervention study. All participants carried out three diets: (1) low fructose (
