International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491
Vol 8, Issue 10, 2016
Original Article
CHEMICAL COMPOSITION AND HEPATOPROTECTIVE EFFECTS OF POLYPHENOLIC FRACTION FROM RIVEA HYPOCRATERIFORMIS IN PARACETAMOL INDUCED LIVER DAMAGE IN WISTAR ALBINO RATS SHIVAKUMAR S. GODIPURGE1, NAVEEN J. BIRADAR2, JAIPRAKASH S. BIRADAR1*, NITIN MAHURKAR3 1Central
Research Laboratory, Department of Chemistry, Gulbarga University, Kalaburagi 585106, India, 2Nargund College of Pharmacy, Bangalore 560085, India, 3Department of Pharmacology, HKES Matoshree Taradevi Rampure Institute of Pharmaceutical Science, Kalaburagi 585105, India Email:
[email protected] Received: 21 Jun 2016 Revised and Accepted: 23 Aug 2016
ABSTRACT Objective: This study was designed to chemical composition and hepatoprotective effects of a polyphenolic fraction of aerial parts of R. hypocrateriformis (PPFRH). It was shown to exhibit strong in vitro lipid peroxidation and scavenging activity against hydroxyl radical.
Methods: The chemical composition of a polyphenolic fraction of R. hypocrateriformis was analyzed by High-performance liquid chromatography method. Hepatocellular injuries induced by paracetamol were assessed by liver damage in Wistar albino rat; the hepatoprotective effect was evaluated by biochemical parameters in rat serum, antioxidant hydroxyl radical scavenging activity and lipid peroxidation in liver tissue.
Results: The polyphenolic fraction of aerial parts of R. hypocrateriformis for lipid peroxidation is significantly (p
