C Anthony Ryan, Neil N Finer, Keith J Barrington. Abstract. Aim-To examine the haemodynamic effects of intravenous magnesium sul- phate on an animal model ...
Archives of Disease in Childhood 1994; 71: Fl51 F155 F151 F151
FETAL AND NEONATAL EDITION
ARCHIVES OF DISEASE IN CHILDHOOD The Journal of the British Paediatric Association
ORIGINAL ARTICLES
Effects of magnesium sulphate and nitric oxide in pulmonary hypertension induced by hypoxia in newborn piglets C Anthony Ryan, Neil N Finer, Keith J Barrington
Department of Newborn Medicine, Royal Alexandra Hospitals N N Finer Department of
Pediatrics and the Perinatal Research
Center, University of Alberta, Edmonton, Alberta, Canada C A Ryan K J Barmngton Correspondence to:
Dr Neil N Finer, Royal Alexandra Hospital, 10240
Kingsway, Edmonton, Alberta, Canada T5H 3V9. Accepted 1O June 1994
vasodilator and may lead to deleterious Abstract Aim-To examine the haemodynamic effects on systemic pressures in critically effects of intravenous magnesium sul- ill newborns. phate on an animal model of neonatal (Arch Dis Child 1994; 71: F151-F155) pulmonary hypertension induced by hypoxia. Methods-The cardiac index (Q), pul- Persistent pulmonary hypertension of the monary arterial pressure (PAP), systemic newbom is characterised by high levels of arterial pressure (SAP), and pulmonary pulmonary vascular resistance, resulting in right (PVRI) and systemic (SVRI) vascular to left shunting across the ductus arteriosus and resistance indices were measured in nine foramen ovale.1-3 The magnitude of this shunt newborn piglets (including three con- depends on the ratio of the systemic and pultrols). Pulmonary hypertension was monary vascular resistance. Vasodilators, such induced by lowering the FiO2 to 0412-0-144 as nitrates, tolazoline, calcium channel blockers after which there was a significant and others, have little potential for directly increase in PAP and PVRI (37% and 142%, decreasing shunt across these fetal channels respectively; p
