Chlorthalidone-Modulated Vascular Responses to ... - Science Direct

7 downloads 0 Views 134KB Size Report
hypertensive rats. Half of the DOCA-salt hypertensive rats were simultaneously given Chlor ... acetate (DOCA, Sigma Chemical Co., St. Louis, MO,. USA, injected ...
Pharmacological Research, Vol. 33, No. 1, 1996

CHLORTHALIDONE-MODULATED VASCULAR RESPONSES TO VASODILATOR STIMULI IN DOCA-SALT HYPERTENSIVE RATS N. S. BISSOLI, E. C. VASQUEZ and A. M. CABRAL Department of Physiological Sciences, Biomedical Center, UFES, Avenue Marechal Campos 1468, Vitoria, 29040-090 ES, Brazil Accepted 13 November 1995 This study was carried out to test the effect of chlorthalidone (Chlor) treatment on the vascular responsiveness to acetylcholine (Ach) and adenosine disphosphate (ADP) under different extracellular calcium concentrations (Cae 2+) in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Half of the DOCA-salt hypertensive rats were simultaneously given Chlor (8 mg day−1, p.o.), after the twentieth day of DOCA, until the fortieth day. Mean arterial pressure (MAP) was reduced (P