CLINICAL AND HISTOPATHOLOGICAL EVALUATION OF COLLAGEN FIBER ORIENTATION USING PICROSIRUS RED STAIN WITH POLARIZING MICROSCOPE IN PATIENTS HAVING ORAL SUBMUCOUS FIBROSIS. SUNIT B PATEL1*, VANDANA S SHAH2, DHARMESH G VASAVADA3, RAKESH SUTARIYA 4 1Senior
Lecturer, Ahemdabad Dental College and Hospital, Ahemdabad, Gujarat.,2Professor and HOD, K M Shah Dental College and Hospital, Vadodara, Gujarat,3Senior Lecturer, M P Dental College and Hospital and Oral Research Center, Vadodara, Gujarat. 4Senior Lecturer, Vaidik Dental College and Research Center, Daman, Gujarat. Corresponding Author: Dr. Sunit Patel, 5- Ajanta Society, ESIC hospital, Kalol- 382721, Gandhinagar, Gujarat, Email Id:
[email protected], contact no. +919998850908 ABSTRACT Background & Objectives: Oral submucous fibrosis (OSMF) is a chronic debilitating disease of oral mucosa and is characterized by generalized fibrosis of the oral soft tissues which tends to present itself clinically as palpable vertical fibrous bands. Hence, this study was conducted to evaluate histopathologically the collagen fibre bundle orientation in relation to epithelium and to find the reason for unidirectional orientation of clinically palpable fibrous bands. Method: The study included 30 cases of Oral submucous fibrosis and 10 cases of normal tissue. Results: Histologically most of the collagen fibres were parallel to the epithelium, and there was a statistically significant difference in orientation between oral submucous fibrosis and control groups (P
