Inge Bülow Pedersen, Peter Laurberg, Nils Knudsen, Torben Jørgensen, Hans ... Marie-Line Jacquemont, Christine Gicquel, Sylvie Cabrol, and Yves Le Bouc.
THE JOURNAL OF
CLINICAL ENDOCRINOLOGY & METABOLISM VOLUME 92, NUMBER 8
AUGUST 2007
Special Features APPROACH TO THE PATIENT: Long-Term Management of Prolactinomas . . . . . . . . . . . . . 2861 Janet A. Schlechte IMAGE IN ENDOCRINOLOGY: Langherans Cell Histiocytosis of the Thyroid Gland Detected by 18FDG-PET/CT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2866 Luca Giovanella, Luca Ceriani, Stefano Crippa, and Luca Mazzucchelli CLINICAL CASE SEMINAR: Heterozygous Mutation of Steroidogenic Factor-1 in 46,XY Subjects May Mimic Partial Androgen Insensitivity Syndrome . . . . . . . . . . . . . . . . . . . . . . . 2868 Re´gis Coutant, Delphine Mallet, Najiba Lahlou, Natacha Bouhours-Nouet, Agne`s Guichet, Lionel Coupris, Anne Croue´, and Yves Morel COMMENTARY: Harmonizing Growth Hormone Measurements: Learning Lessons for the Future . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2874 Gilbert E. Wieringa and Peter J. Trainer
Editorials Editorial: The Dexamethasone-Suppressed Corticotropin-Releasing Hormone Test for the Diagnosis of Cushing’s Syndrome: What Have We Learned in 14 Years? . . . . . . . . . . . . . . . . 2876 Lynnette Nieman Editorial: The Role of Glucagon in Postprandial Hyperglycemia—The Jury’s Still Out. . . . . 2879 Jennifer Bollyky and Carla J. Greenbaum Editorial: Preventing Ovarian Hyperstimulation Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . 2882 M. A. Aboulghar
Endocrine Care Insulin Resistance, Insulin Response, and Obesity as Indicators of Metabolic Risk . . . . . . . 2885 Ele Ferrannini, Beverley Balkau, Simon W. Coppack, Jacqueline M. Dekker, Andrea Mari, John Nolan, Mark Walker, Andrea Natali, Henning Beck-Nielsen, and the RISC Investigators
THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (ISSN 0021-972X; IPM 0059676) is the official journal of The Endocrine Society, published monthly by The Endocrine Society, 8401 Connecticut Avenue, Suite 900, Chevy Chase, MD 20815-5817. Periodicals postage paid at Chevy Chase, MD and at additional mailing offices. Subscription rates are $449 ($597 international); institutions $838 ($972 international); institutions on-line only $756 (U.S. and international); in training $254 ($350 international); single copy $66 ($75 international). Society member dues of $266 ($334 international) includes print and online access to one primary journal and online access to an additional two primary journals. Subscription prices subject to change. All subscriptions start with the January issue. To order call (301) 941-0210. All subscription orders for customers in Japan must be placed through our exclusive agent, USACO Corporation, 17-12, Higashi-Azabu, Minatu-ku, Tokyo 105, Japan. Telephone 033505-6161. Please contact USACO for 2007 yen rates. Printed in the U.S.A. POSTMASTER: send address changes to The Journal of Clinical Endocrinology & Metabolism, 8401 Connecticut Avenue, Suite 900, Chevy Chase, MD 20815-5817. Indexed by Index Medicus, Current Contents, BIOSIS, CAB ABSTRACTS, CAB HEALTH, Elsevier BIOBASE/Current Awareness in Biological Sciences, National Biological Service, EMBASE/Excerpta Medica, and Sociedad Iberoamericana de Informacio´n Cientı´fica (SIIC). Printed on acid-free paper. Table of Contents and abstracts for each issue available on the issue mail date on The Endocrine Society Home Page at http: //jcem.endojournals.org. Copyright © 2007 by The Endocrine Society.
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Contents continued Evaluation of the Biological Activity of a Growth Hormone (GH) Mutant (R77C) and Its Impact on GH Responsiveness and Stature . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2893 Vibor Petkovic, Ame´lie Besson, Mario Thevis, Didier Lochmatter, Andre´e Eble´, Christa E. Flu¨ck, and Primus E. Mullis Combination Chemotherapy Including Combretastatin A4 Phosphate and Paclitaxel Is Effective against Anaplastic Thyroid Cancer in a Nude Mouse Xenograft Model . . . . . . . . . 2902 Sai-Ching J. Yeung, Miaorong She, Huiling Yang, Jingxuan Pan, Lily Sun, and David Chaplin Meal-Stimulated Glucagon Release Is Associated with Postprandial Blood Glucose Level and Does Not Interfere with Glycemic Control in Children and Adolescents with NewOnset Type 1 Diabetes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2910 Sven Po¨rksen, Lotte B. Nielsen, Anne Kaas, Mirjana Kocova, Francesco Chiarelli, Cathrine Ørskov, Jens J. Holst, Kenneth B. Ploug, Philip Hougaard, Lars Hansen, Henrik B. Mortensen, and the Hvidøre Study Group on Childhood Diabetes Elastography: New Developments in Ultrasound for Predicting Malignancy in Thyroid Nodules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2917 T. Rago, F. Santini, M. Scutari, A. Pinchera, and P. Vitti Infantile Hypophosphatasia: Transplantation Therapy Trial Using Bone Fragments and Cultured Osteoblasts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2923 Richard A. Cahill, Deborah Wenkert, Sharon A. Perlman, Ann Steele, Stephen P. Coburn, William H. McAlister, Steven Mumm, and Michael P. Whyte Dopamine Agonist Cabergoline Reduces Hemoconcentration and Ascites in Hyperstimulated Women Undergoing Assisted Reproduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2931 ´ lvarez, Luis Martı´-Bonmatı´, Edurne Novella-Maestre, Roberto Sanz, Rau´l Go´mez, Claudio A Manuel Ferna´ndez-Sa´nchez, Carlos Simo´n, and Antonio Pellicer Genetics of Carney Triad: Recurrent Losses at Chromosome 1 but Lack of Germline Mutations in Genes Associated with Paragangliomas and Gastrointestinal Stromal Tumors . . . . 2938 Ludmila Matyakhina, Thalia A. Bei, Sarah R. McWhinney, Barbara Pasini, Silke Cameron, Bastian Gunawan, Sotirios G. Stergiopoulos, Sosipatros Boikos, Michael Muchow, Amalia Dutra, Evgenia Pak, Elias Campo, Maria C. Cid, Fulgencio Gomez, Rolf C. Gaillard, Guillaume Assie, Laszlo Fu¨zesi, Bora E. Baysal, Charis Eng, J. Aidan Carney, and Constantine A. Stratakis C-Reactive Protein before and after Weight Loss in Overweight Women with and without Polycystic Ovary Syndrome. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2944 Lisa J. Moran, Manny Noakes, Peter M. Clifton, Gary A. Wittert, Damien P. Belobrajdic, and Robert J. Norman Cyclical Changes in Calcium Metabolism across the Menstrual Cycle in Women with Premenstrual Dysphoric Disorder. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2952 Susan Thys-Jacobs, Don McMahon, and John P. Bilezikian Blood Glucose Control by a Model Predictive Control Algorithm with Variable Sampling Rate Versus a Routine Glucose Management Protocol in Cardiac Surgery Patients: A Randomized Controlled Trial. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2960 Roman Hovorka, Jaromir Kremen, Jan Blaha, Michal Matias, Katerina Anderlova, Lenka Bosanska, Tomas Roubicek, Malgorzata E. Wilinska, Ludovic J. Chassin, Stepan Svacina, and Martin Haluzik Measurement of Salivary Cortisol Concentration in the Assessment of Adrenal Function in Critically Ill Subjects: A Surrogate Marker of the Circulating Free Cortisol. . . . . . . . . . . . . 2965 Baha M. Arafah, Fumie J. Nishiyama, Haytham Tlaygeh, and Rana Hejal Dexamethasone-Suppressed Corticotropin-Releasing Hormone Stimulation Test for Diagnosis of Mild Hypercortisolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2972 Dana Erickson, Neena Natt, Todd Nippoldt, William F. Young, Jr., Paul C. Carpenter, Tanya Petterson, and Teresa Christianson Progressive Reduction in Body Weight after Treatment with the Amylin Analog Pramlintide in Obese Subjects: A Phase 2, Randomized, Placebo-Controlled, Dose-Escalation Study . 2977 Louis Aronne, Ken Fujioka, Vanita Aroda, Kim Chen, Amy Halseth, Nicole C. Kesty, Colleen Burns, Cameron W. Lush, and Christian Weyer
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Contents continued Loss of Integrity of Thyroid Morphology and Function in Children Born to Mothers with Inadequately Treated Graves’ Disease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2984 Marlies J. E. Kempers, A. S. Paul van Trotsenburg, Rick R. van Rijn, Anne M. J. B. Smets, Bert J. Smit, Jan J. M. de Vijlder, and Thomas Vulsma Free/Dissociable Insulin-Like Growth Factor (IGF)-I, Not Total IGF-I, Correlates with Growth Response during Growth Hormone Treatment in Children Born Small for Gestational Age . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2992 Ellen M. N. Bannink, Jaap van Doorn, Paul G. H. Mulder, and Anita C. S. Hokken-Koelega Normocalcemic Primary Hyperparathyroidism: Further Characterization of a New Clinical Phenotype . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3001 H. Lowe, D. J. McMahon, M. R. Rubin, J. P. Bilezikian, and S. J. Silverberg Altered Platelet Plug Formation in Hyperthyroidism and Hypothyroidism . . . . . . . . . . . . . 3006 Monika Homoncik, Alois Gessl, Arnulf Ferlitsch, Bernd Jilma, and Heinrich Vierhapper Growth Hormone Increases Final Height in Patients with Juvenile Idiopathic Arthritis: Data from a Randomized Controlled Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3013 Susanne Bechtold, Peter Ripperger, Robert Dalla Pozza, Walter Bonfig, Renate Ha¨fner, Hartmut Michels, and Hans Peter Schwarz Patients with Classic Congenital Adrenal Hyperplasia Have Decreased Epinephrine Reserve and Defective Glycemic Control during Prolonged Moderate-Intensity Exercise. . . . . 3019 Liza Green-Golan, Catherine Yates, Bart Drinkard, Carol VanRyzin, Graeme Eisenhofer, Martina Weise, and Deborah P. Merke Determinants of Early Atherosclerosis in Obese Children and Adolescents . . . . . . . . . . . . . 3025 Ve´ronique Beauloye, Francis Zech, Hiep Tran Thi Mong, Philippe Clapuyt, Marc Maes, and Sonia M. Brichard Growth Hormone Treatment in Adolescent Males with Idiopathic Short Stature: Changes in Body Composition, Protein, Fat, and Glucose Metabolism . . . . . . . . . . . . . . . . . . . . . . . . 3033 Tamara S. Hannon, Kapriel Danadian, Chittiwat Suprasongsin, and Silva A. Arslanian Ovarian Androgen Production in Postmenopausal Women . . . . . . . . . . . . . . . . . . . . . . . . . . 3040 Robin H. Fogle, Frank Z. Stanczyk, Xiaohua Zhang, and Richard J. Paulson Sleep Loss Alters Basal Metabolic Hormone Secretion and Modulates the Dynamic Counterregulatory Response to Hypoglycemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3044 Sebastian M. Schmid, Manfred Hallschmid, Kamila Jauch-Chara, Nadine Bandorf, Jan Born, and Bernd Schultes Postprandial Lipemia Associates with Liver Fat Content . . . . . . . . . . . . . . . . . . . . . . . . . . . 3052 Niina Matikainen, Sakari Ma¨ntta¨ri, Jukka Westerbacka, Satu Vehkavaara, Nina Lundbom, Hannele Yki-Ja¨rvinen, and Marja-Riitta Taskinen Endocrine Features of Menstrual Cycles in Middle and Late Reproductive Age and the Menopausal Transition Classified According to the Staging of Reproductive Aging Workshop (STRAW) Staging System. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3060 Georgina E. Hale, Xue Zhao, Claude L. Hughes, Henry G. Burger, David M. Robertson, and Ian S. Fraser Effects of the Phytoestrogen Genistein on Some Predictors of Cardiovascular Risk in Osteopenic, Postmenopausal Women: A Two-Year Randomized, Double-Blind, PlaceboControlled Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3068 Marco Atteritano, Herbert Marini, Letteria Minutoli, Francesca Polito, Alessandra Bitto, Domenica Altavilla, Susanna Mazzaferro, Rosario D’Anna, Maria Letizia Cannata, Agostino Gaudio, Alessia Frisina, Nicola Frisina, Francesco Corrado, Francesco Cancellieri, Carla Lubrano, Michele Bonaiuto, Elena Bianca Adamo, and Francesco Squadrito
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Contents continued Relationship between Bone Mineral Density Changes and Fracture Risk Reduction in Patients Treated with Strontium Ranelate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3076 Olivier Bruyere, Christian Roux, Johann Detilleux, Daniel O. Slosman, Tim D. Spector, Patrice Fardellone, Kim Brixen, Jean-Pierre Devogelaer, Manuel Diaz-Curiel, Carlina Albanese, Jean-Marc Kaufman, Stig Pors-Nielsen, and Jean-Yves Reginster Heritability of Plasma Adiponectin Levels and Body Mass Index in Twins . . . . . . . . . . . . . . 3082 Maurizio Cesari, Krzysztof Narkiewicz, Renzo De Toni, Enrico Aldighieri, Christopher J. Williams, and Gian Paolo Rossi Hormonal and Nutritional Effects on Cardiovascular Risk Markers in Young Women . . . . . 3089 Elizabeth A. Lawson, Karen K. Miller, Vani A. Mathur, Madhusmita Misra, Erinne Meenaghan, David B. Herzog, and Anne Klibanski Improvement in Growth after Two Years of Growth Hormone Therapy in Very Young Children Born Small for Gestational Age and without Spontaneous Catch-Up Growth: Results of a Multicenter, Controlled, Randomized, Open Clinical Trial . . . . . . . . . . . . . . . . . . . . . . . 3095 Jesu´s Argente, Ricardo Gracia, Lourdes Iba´n˜ez, Antonio Oliver, Emilio Borrajo, Amaya Vela, Juan Pedro Lo´pez-Siguero, M. Llanos Moreno, and Francisco Rodrı´guez-Hierro, on behalf of the Spanish SGA Working Group Radioimmunoassay and Tandem Mass Spectrometry Measurement of Bedtime Salivary Cortisol Levels: A Comparison of Assays to Establish Hypercortisolism . . . . . . . . . . . . . . . . 3102 Smita K. Baid, Ninet Sinaii, Matt Wade, Domenica Rubino, and Lynnette K. Nieman Evidence for Thyroid Hormone as a Positive Regulator of Serum Thyrotropin Bioactivity . 3108 Juliana H. A. Oliveira, Erika R. Barbosa, Teresa Kasamatsu, and Julio Abucham Surgery or Surveillance for Mild Asymptomatic Primary Hyperparathyroidism: A Prospective, Randomized Clinical Trial . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3114 Elena Ambrogini, Filomena Cetani, Luisella Cianferotti, Edda Vignali, Chiara Banti, Giuseppe Viccica, Annalisa Oppo, Paolo Miccoli, Piero Berti, John P. Bilezikian, Aldo Pinchera, and Claudio Marcocci An Increased Incidence of Overt Hypothyroidism after Iodine Fortification of Salt in Denmark: A Prospective Population Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3122 Inge Bu¨low Pedersen, Peter Laurberg, Nils Knudsen, Torben Jørgensen, Hans Perrild, Lars Ovesen, and Lone Banke Rasmussen Insulin Sensitivity after Metformin Suspension in Normal-Weight Women with Polycystic Ovary Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3128 Stefano Palomba, Angela Falbo, Tiziana Russo, Francesco Manguso, Achille Tolino, Fulvio Zullo, Pierpaolo De Feo, and Francesco Orio, Jr. Concomitant Reduction of Low-Density Lipoprotein-Cholesterol and Biomarkers of Inflammation with Low-Dose Simvastatin Therapy in Patients with Type 1 Diabetes . . . . . 3136 Ishwarlal Jialal, Eric Miguelino, Steven C. Griffen, and Sridevi Devaraj High Risk of Congenital Hypothyroidism in Multiple Pregnancies . . . . . . . . . . . . . . . . . . . . 3141 Antonella Olivieri, Emanuela Medda, Simona De Angelis, Herbert Valensise, Mario De Felice, Cristina Fazzini, Isabella Cascino, Viviana Cordeddu, Mariella Sorcini, Maria Antonietta Stazi, and The Study Group for Congenital Hypothyroidism BRIEF REPORT: 11p15 Imprinting Center Region 1 Loss of Methylation Is a Common and Specific Cause of Typical Russell-Silver Syndrome: Clinical Scoring System and Epigenetic-Phenotypic Correlations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3148 Ire`ne Netchine, Sylvie Rossignol, Marie-Noe¨lle Dufourg, Salah Azzi, Alexandra Rousseau, Laurence Perin, Muriel Houang, Virginie Steunou, Blandine Esteva, Nathalie Thibaud, Marie-Charles Raux Demay, Fabienne Danton, Elzbieta Petriczko, Anne-Marie Bertrand, Claudine Heinrichs, Jean-Claude Carel, Guy-Andre´ Loeuille, Graziella Pinto, Marie-Line Jacquemont, Christine Gicquel, Sylvie Cabrol, and Yves Le Bouc BRIEF REPORT; Reduced Sun Exposure Does Not Explain the Inverse Association of 25Hydroxyvitamin D with Percent Body Fat in Older Adults . . . . . . . . . . . . . . . . . . . . . . . . . . 3155 Susan S. Harris and Bess Dawson-Hughes BRIEF REPORT: Random Variability in Congenital Hypothyroidism from Thyroid Dysgenesis over 16 Years in Québec . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3158 Johnny Deladoe¨y, Nicole Be´langer, and Guy Van Vliet
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Contents continued
Other Original Articles Cytotoxic T-Lymphocyte Associated Antigen 4 Gene Polymorphisms and Autoimmune Thyroid Disease: A Meta-Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3162 Fotini K. Kavvoura, Takashi Akamizu, Takuya Awata, Yoshiyuki Ban, Dimitry A. Chistiakov, Irena Frydecka, Abbas Ghaderi, Stephen C. Gough, Yuji Hiromatsu, Rafal Ploski, Pei-Wen Wang, Yoshio Ban, Tomasz Bednarczuk, Emma I. Chistiakova, Marcin Chojm, Joanne M. Heward, Hitomi Hiratani, Suh-Hang Hank Juo, Lidia Karabon, Shigehiro Katayama, Susumu Kurihara, Rue-Tsuan Liu, Ikuyo Miyake, Gholam-Hossein R. Omrani, Edyta Pawlak, Matsuo Taniyama, Teruaki Tozaki, and John P. A. Ioannidis Linkage of Genes to Total Lean Body Mass in Normal Women . . . . . . . . . . . . . . . . . . . . . . . 3171 Gregory Livshits, Bernet S. Kato, Scott G. Wilson, and Tim D. Spector Vitamin D 1␣-Hydroxylase Gene Mutations in Patients with 1␣-Hydroxylase Deficiency . . . 3177 Chan Jong Kim, Larry E. Kaplan, Farzana Perwad, Ningwu Huang, Amita Sharma, Yong Choi, Walter L. Miller, and Anthony A. Portale Association of Prostaglandin E Synthase 2 (PTGES2) Arg298His Polymorphism with Type 2 Diabetes in Two German Study Populations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3183 Inke Nitz, Eva Fisher, Harald Grallert, Yun Li, Christian Gieger, Diana Rubin, Heiner Boeing, Joachim Spranger, Inka Lindner, Stefan Schreiber, Wolfgang Rathmann, Henning Gohlke, Angela Do¨ring, H.-Erich Wichmann, Ju¨rgen Schrezenmeir, Frank Do¨ring, and Thomas Illig Serum Sex Hormone-Binding Globulin Levels in Healthy Children and Girls with Precocious Puberty before and during Gonadotropin-Releasing Hormone Agonist Treatment . . . 3189 K. Sørensen, A. M. Andersson, N. E. Skakkebæk, and A. Juul Association between a C/T Polymorphism in Exon 33 of the Thyroglobulin Gene Is Associated with Relapse of Graves’ Hyperthyroidism after Antithyroid Withdrawal in Taiwanese. 3197 Jeng-Yueh Hsiao, Ming-Chia Hsieh, Kai-Jen Tien, Shih-Chie Hsu, Shyi-Jang Shin, and Shiu-Ru Lin Ghrelin Suppresses Secretion of Luteinizing Hormone in Humans . . . . . . . . . . . . . . . . . . . . 3202 Michael Kluge, Petra Schu¨ssler, Manfred Uhr, Alexander Yassouridis, and Axel Steiger The Catechol-O-Methyltransferase Met158 Low-Activity Allele and Association with Nonvertebral Fracture Risk in Elderly Men . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3206 Lisette Stolk, Joyce B. J. van Meurs, Mila Jhamai, Pascal P. Arp, Johannes P. T. van Leeuwen, Albert Hofman, Frank H. de Jong, Huibert A. P. Pols, and Andre´ G. Uitterlinden Metformin Suppresses Interleukin (IL)-1-Induced IL-8 Production, Aromatase Activation, and Proliferation of Endometriotic Stromal Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3213 Yuri Takemura, Yutaka Osuga, Osamu Yoshino, Akiko Hasegawa, Tetsuya Hirata, Yasushi Hirota, Emi Nose, Chieko Morimoto, Miyuki Harada, Kaori Koga, Toshiki Tajima, Tetsu Yano, and Yuji Taketani Detailed Analysis of Variation at and around Mitochondrial Position 16189 in a Large Finnish Cohort Reveals No Significant Associations with Early Growth or Metabolic Phenotypes at Age 31 Years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3219 Sreena Das, Amanda J. Bennett, Ulla Sovio, Aimo Ruokonen, Hannu Martikainen, Anneli Pouta, Anna-Liisa Hartikainen, Stephen Franks, Paul Elliott, Joanna Poulton, Marjo-Riitta Ja¨rvelin, and Mark I. McCarthy Association of Serum Retinol-Binding Protein 4 and Visceral Adiposity in Chinese Subjects with and without Type 2 Diabetes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3224 Weiping Jia, Haiya Wu, Yuqian Bao, Chen Wang, Junxi Lu, Jiehua Zhu, and Kunsan Xiang
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Contents continued The Circadian Rhythm of Osteoprotegerin and Its Association with Parathyroid Hormone Secretion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3230 F. Joseph, B. Y. Chan, B. H. Durham, A. M. Ahmad, S. Vinjamuri, J. A. Gallagher, J. P. Vora, and W. D. Fraser Ghrelin Affects the Release of Luteolytic and Luteotropic Factors in Human Luteal Cells . . 3239 Anna Tropea, Federica Tiberi, Francesca Minici, Mariateresa Orlando, Maria Francesca Gangale, Federica Romani, Fiorella Miceli, Stefania Catino, Salvatore Mancuso, Maurizio Sanguinetti, Antonio Lanzone, and Rosanna Apa Impact of Fatness, Fitness, and Ethnicity on the Relationship of Nocturnal Ghrelin to 24Hour Luteinizing Hormone Concentrations in Adolescent Girls . . . . . . . . . . . . . . . . . . . . . . 3246 J. Z. Kasa-Vubu, A. Rosenthal, E. G. Murdock, and K. B. Welch Nephroblastoma Overexpressed/Cysteine-Rich Protein 61/Connective Tissue Growth Factor/Nephroblastoma Overexpressed Gene-3 (NOV/CCN3), a Selective Adrenocortical Cell Proapoptotic Factor, Is Down-Regulated in Childhood Adrenocortical Tumors. . . . . . . 3253 Mabrouka Doghman, Malika Arhatte, He´le`ne Thibout, Giovanna Rodrigues, Juliana De Moura, Se´bastien Grosso, Alina Nico West, Maryvonne Laurent, Jean-Christophe Mas, Andre´ Bongain, Gerard P. Zambetti, Bonald C. Figueiredo, Patrick Auberger, Ce´cile Martinerie, and Enzo Lalli Transcriptional Activation of Steroidogenic Factor-1 by Hypomethylation of the 5ⴕ CpG Island in Endometriosis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3261 Qing Xue, Zhihong Lin, Ping Yin, Magdy P. Milad, You-Hong Cheng, Edmond Confino, Scott Reierstad, and Serdar E. Bulun Molecular Evidence for a Link between the N363S Glucocorticoid Receptor Polymorphism and Altered Gene Expression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3268 Christine M. Jewell and John A. Cidlowski Brain White Matter Expansion in Human Obesity and the Recovering Effect of Dieting . . . 3278 Lauri T. Haltia, Antti Viljanen, Riitta Parkkola, Nina Kemppainen, Juha O. Rinne, Pirjo Nuutila, and Valtteri Kaasinen Lower Levels of Urinary 2-Hydroxyestrogens in Polycystic Ovary Syndrome . . . . . . . . . . . . 3285 Sana Salih, Xia Xu, Timothy D. Veenstra, Antoni J. Duleba, Hala Fouad, Manubai Nagamani, and Ayman Al-Hendy Transient Scrotal Hyperthermia and Levonorgestrel Enhance Testosterone-Induced Spermatogenesis Suppression in Men through Increased Germ Cell Apoptosis . . . . . . . . . . . . . . 3292 Christina Wang, Yu-Gui Cui, Xing-Hai Wang, Yue Jia, Amiya Sinha Hikim, Yan-He Lue, Jian-Son Tong, Li-Xin Qian,† Jia-Hao Sha, Zuo-Min Zhou, Laura Hull, Andrew Leung, and Ronald S. Swerdloff Isolated 46,XY Gonadal Dysgenesis in Two Sisters Caused by a Xp21.2 Interstitial Duplication Containing the DAX1 Gene. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3305 Michela Barbaro, Mikael Oscarson, Jacqueline Schoumans, Johan Staaf, Sten A. Ivarsson, and Anna Wedell Altered Activity of 11-Hydroxysteroid Dehydrogenase Types 1 and 2 in Skeletal Muscle Confers Metabolic Protection in Subjects with Type 2 Diabetes . . . . . . . . . . . . . . . . . . . . . . 3314 Christina Jang, Varuni R. Obeyesekere, Rodney J. Dilley, Zygmunt Krozowski, Warrick J. Inder, and Frank P. Alford BRIEF REPORT: Germline CDKN1B/p27Kip1 Mutation in Multiple Endocrine Neoplasia . . . 3321 Marianthi Georgitsi, Anniina Raitila, Auli Karhu, Rob B. van der Luijt, Cora M. Aalfs, Timo Sane, Outi Vierimaa, Markus J. Ma¨kinen, Karoliina Tuppurainen, Ralph Paschke, Oliver Gimm, Christian A. Koch, Sadi Gu¨ndogdu, Anneke Lucassen, Marc Tischkowitz, Louise Izatt, Simon Aylwin, Gul Bano, Shirley Hodgson, Ernesto De Menis, Virpi Launonen, Pia Vahteristo, and Lauri A. Aaltonen BRIEF REPORT: Effects of Diet-Induced Moderate Weight Reduction on Intrahepatic and Intramyocellular Triglycerides and Glucose Metabolism in Obese Subjects . . . . . . . . . . . . . 3326 Fumihiko Sato, Yoshifumi Tamura, Hirotaka Watada, Naoki Kumashiro, Yasuhiro Igarashi, Hiroshi Uchino, Tadayuki Maehara, Shinsuke Kyogoku, Satoshi Sunayama, Hiroyuki Sato, Takahisa Hirose, Yasushi Tanaka, and Ryuzo Kawamori
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Contents continued BRIEF REPORT: The Type II Iodothyronine Deiodinase Is Up-Regulated in Skeletal Muscle during Prolonged Critical Illness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3330 Liese Mebis, Lies Langouche, Theo J. Visser, and Greet Van den Berghe BRIEF REPORT: Water Drinking Induces Thermogenesis through Osmosensitive Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3334 Michael Boschmann, Jochen Steiniger, Gabriele Franke, Andreas L. Birkenfeld, Friedrich C. Luft, and Jens Jordan BRIEF REPORT: Genomic Polymorphism at the Interferon-Induced Helicase (IFIH1) Locus Contributes to Graves’ Disease Susceptibility . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3338 Alison Sutherland, Jocelyn Davies, Catherine J. Owen, Suresh Vaikkakara, Christine Walker, Timothy D. Cheetham, R. Andrew James, Petros Perros, Peter T. Donaldson, Heather J. Cordell, Richard Quinton, and Simon H. S. Pearce
Announcements and Resources Erratum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3032 Endocrine-Related Resources from the National Institutes of Health . . . . . . . . . . . . . . . . . . . . . .3356 National Hormone & Peptide Program (NHPP): New Recombinant Hormones, Hypothalamic Peptides, Natural Hormones, New Antisera, & Expanded Hormone Assay Services Available . . .3360
The Endocrine Society Editorial Board . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14A Author and Subscription Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .15A Affirmation of Originality and Assignment of Copyright . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16A Endocrinology & Metabolism News . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .17A The Endocrine Society Laureate Awards . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3342 The Endocrine Society 2007 Laureate Awards . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3344 Employment Opportunities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3363
The Hormone Foundation’s Patient Guide to Management of Maternal Hypothyroidism Before, During and After Pregnancy Facing Listing by Interests COVER:
Top row, Statistical parametric map of brain regions where obese subjects had greater volumes of white matter compared to lean subjects. Bottom row, Brain region that showed shrinkage of white matter after dieting for 6 wk. From the article by Haltia et al., in this issue, pages 3278 – 3284.
INDEX OF ADVERTISERS Abbott Laboratories 31A Astellas Pharma US Inc. 19A–20A Bayer Schering Pharma AG After 32A (International Only) Eli Lilly & Company 34A–37A Indevus Pharmaceuticals 39A Merck Human Health Division Before 41A-2, 41A Mylan Pharmaceuticals 13A–15A
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Novartis Pharmaceuticals Corporation Before 41A-1 Novo Nordisk Pharmaceuticals, Inc. 11A–12A, 23A–24A, 27A–28A Pfizer U.S. Pharmaceuticals Cover 2–2A, Before 25A Sanofi-Aventis Before 17A-1 Serono Laboratories Cover 4 Takeda Pharmaceuticals America, Inc. Before 29A, 29A
