Clinicopathological features and treatment

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Nov 2, 2015 - 2Radiation Oncology, King Fahad Medical City, Riyadh, Saudi Arabia. Full list of author information is available at the end of the article. © 2015 AL-Qahtani ..... 2000;53:635–44. Submit your next manuscript to BioMed Central.
AL-Qahtani et al. Journal of Otolaryngology Head & Neck Surgery (2015) 44:48 DOI 10.1186/s40463-015-0102-6

ORIGINAL RESEARCH ARTICLE

Open Access

“Clinicopathological features and treatment outcomes of differentiated thyroid cancer in Saudi children and adults” Khalid Hussain AL-Qahtani1, Mutahir A. Tunio2*, Mushabbab Al Asiri3, Naji J. Aljohani4, Yasser Bayoumi5, Khalid Riaz2 and Wafa AlShakweer6

Abstract Introduction: Age is an important prognostic factor in differentiated thyroid cancer (DTC). Our aim was to evaluate differences in clinicopathological features and treatment outcomes among children and adult patients with DTC. Materials and methods: We studied 27 children (below 18 years) with DTC treated during the period 2000–2012 and were compared with (a) 78 adults aged 19–25 years and (b) 52 adults aged 26–30 years treated during the same period in terms of their clinicopathological features and long term treatment outcomes. Locoregional recurrence (LRR), locoregional control (LRC), distant metastasis (DM), distant metastasis control (DMC), disease free survival (DFS) and overall survival (OS) rates were evaluated. Results: Mean age of children was 13.5 years (range: 5–18), while mean age of adults was 24.6 years (range: 19–30). In children, female: male ratio was 2.85:1, and in adults female: male ratio was 7.1:1 (P = 0.041). No significant difference in tumor size was seen between the two groups (P = 0.653). According to American Thyroid Association (ATA) risk stratification classification, the children (85.2 %) were found to have at high risk as compared to adults P = 0.001. Post-thyroidectomy complications and RAI induced toxicities were observed more in children than adults (P = 0.043 and P = 0.041 respectively). LRR occurred in 6 (22.2 %), 9 (11.5 %) and 3 (5.8 %) in age groups of