Concentrations of Salivary Testosterone and ... - Clinical Chemistry

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Dec 11, 1990 - with a double antibody RIA kit (Techland, Liege, Be!- gium). Statistical analysis. For comparison of means we used the unpaired Student's t-test ...

CLIN. CHEM. 37/2, 180-185 (1991)

Concentrations of Salivary Testosterone and Plasma Total, Non-Sex-Hormone-Binding Globulin-Bound, and Free Testosterone in Normal and Hirsute Women during Administration of Dexamethasone/Synthetic Corticotropin L. M. J. W. Swlnkele,H.J. C. van Hoof,H. A. Rou,1 A. G. H. Smals,1 and Th. J. Benraad Preliminary data indicate that the concentration of circulating cortisol may affect the binding of testosterone to plasma proteins. This interdependency was evaluated by the assessment of plasma cortisol, salivary (ST) and plasma total testosterone (TT), testosterone not bound to sex-hormone-binding globulin (n-SHBGT), and free testosterone (Fe) in normal and in hyperandrogenemic women during combined dexamethasone/synthetic corticotropin administration. The concentrations of IT, FT, and ST significantly increased (P

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