Contd... Contd...

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VNN2. 0.3. PIAS2. 0.3. SGMS2. 0.3. DPF1. 0.3. BARX2. 0.3. SCARF1. 0.3. ELMO1. 0.3. NUAK1. 0.3. ARNT2. 0.3. THRAP3. 0.3. GFPT2. 0.3. AHNAK. 0.3. XIRP1.
Supplementary Table 2: Genes positively correlating with FSCN1 expression (pearson correlation > 0.3) in CRC Gene Symbol LCK DNAH2 CEP170 UBASH3B SPHK1 CD109 SOX8 DPYSL2 NFATC1 PRKCDBP PIAS3 ETV5 CXCR4 NXN CHST15 SLC39A6 DBN1 ETV1 SERPINB5 TRERF1 LRRC8A TGFB1 TNNT1 HAPLN3 MAP3K6 FKBP9P1 MAPRE2 PRDM8 ADGRG6 SRGAP2 MTCL1 ZNF385A DUSP4 GRK5 PMP22 MAPK11 ZNF24 SOX13 PIK3AP1 ANO1 ZNF114 DUSP7 FYN POLR2A AGAP2-AS1 HRK ONECUT3 C10ORF10 SHF RTN4RL2 HOXC9 MDFI

Pearson Score 0.53 0.53 0.52 0.52 0.51 0.5 0.5 0.49 0.49 0.49 0.48 0.47 0.47 0.47 0.46 0.46 0.45 0.45 0.45 0.45 0.45 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.41 0.41 0.41

Contd...

Supplementary Table 2: Contd... RELL1 PFKP ANXA2R CHPF TBC1D8 GNB5 ANP32E TRNP1 SLC7A11 CFAP61 FAM78B ARHGAP22 BCL6 KIFC3 NTSR1 PKM PTAFR LAT2 PRSS12 HOMER2 GNLY CALHM2 RILPL2 EEF1DP3 RNF125 CHSY1 HIVEP3 ARSI C10ORF54 TRIB2 CDR2L FZD2 GNAI2 FAM171A2 C18ORF25 VMO1 KCTD1 BEAN1 RCOR2 KIAA0040 VAT1 TTYH3 TRIM7 IER5 RASA3 ABLIM3 AFAP1L2 COLGALT2 N4BP3 GAREM SNX29 TMEM169 ICAM1 ITGB7

0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.38 0.38

Contd...

Supplementary Table 2: Contd... Gene Symbol LOXL1 MFI2 CLEC2B ARL4C PNMA1 BCAR1 CKAP4 PLK2 LILRA3 RGS19 P3H3 PPP1R18 DNAAF3 FAM167A ANTXR2 ZNF407 CCDC88A PCDHGA4 PLXND1 PKD1L3 SLC27A1 ROBO3 FAM114A1 ADAM8 ATP6V1B2 MYRF S100A16 ZBTB46 ENO2 GNA15 MFGE8 NFKB2 PLXNB3 RAB27B PVRL2 NAPG ITGA10 PPP4R1 DCBLD2 RNF122 SEMA4B IKBIP AIF1L MAP7D1 SLC41A1 MIER2 WDFY2 KISS1R C1ORF198 PEAR1 ALOXE3 C2CD4C AHR

Supplementary Table 2: Contd... Pearson Score 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.36

Contd...

HIF1A IL1RN MEIS2 MAP2K1 PPP3CA PIP4K2A SERPINB8 ROCK1 RAC2 SELPLG UBTD1 GAS2L1 PNMA2 GGN ZNF467 ALKBH5 ITPRIP TOR1AIP2 FIBCD1 SMCHD1 DUSP5P1 AP1S3 TRIM47 ANXA2P2 ANXA1 BTG1 CA8 CALB2 COL13A1 ELK3 EMP3 EFNA5 FHL3 GNS GALNT1 HOXC6 MBP MMP14 NPC1 OPRL1 PODXL PML LGMN PTPN14 IRGM TSPAN4 TFAP2A STXBP1 FBXL16 BCL9L AHNAK2 GFI1B ARHGAP10 S1PR2

0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35

Contd...

Supplementary Table 2: Contd... Gene Symbol HPSE TLR6 FSTL3 SEMA6B FOXD4L1 SIX4 SLC15A4 ARHGEF4 PLLP TVP23B SLC4A11 SYNE3 PCDHGA5 RIMBP3 ZIC5 GPR161 SWAP70 WWTR1 ERMN MOB3A TMEM263 FAM69C INO80C ANXA5 BCAT1 BPIFA2 EPHB6 KDSR GUCA1A LMNA MAS1 CHST6 MTMR9 PDE4D PLOD1 PTRF SCN1B TPO SLK SEC24D LHFPL2 AKAP12 HCST RAB35 TRPV2 RAB8B MEIS3 ATP8B2 PLBD2 CCDC109B ZCCHC2 MAP1S PHLDA1

Supplementary Table 2: Contd... Pearson Score 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34

Contd...

EMILIN2 OSBPL8 TREM1 GPRIN1 TSHZ2 RIMBP3C AHDC1 LMCD1 CDCP1 P3H1 ACTN1 ADARB1 ALOX5 ANXA2 BNIP3L CTSB FCER1G FCGR3A EXTL3 GJB5 HOXB4 KLC1 CD82 MAP3K5 DCBLD1 NRTN POLG CDK17 PCSK5 RBBP8 PTGER2 QSOX1 SLC11A1 TLR5 TCN1 FLJ30679 CDK2AP1 GPR68 NRP1 PPFIBP1 DOCK4 RABGAP1L DHRS2 PDLIM7 STK17B MAP4K4 ZBED2 ADAMTS2 PDE10A ZNF271P DOCK5 SYNPO2L RAI1 FUT11

0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.34 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33

Contd...

Supplementary Table 2: Contd... Gene Symbol CEP85L LETM2 COL5A3 CERCAM CAMSAP1 SLAMF8 PCDHGA6 CEP170P1 FAM63B ZFPM1 PPP6R1 HEY1 ESCO1 LRP10 PCDHGA12 ATP9B EPG5 OSCAR CABLES1 LINC00923 LINC00589 ADGRE2 ADAR RHOG ASPH BMP1 CAPN2 FCGR2A ETS1 FLII HOXC5 LOX LMX1B MSN NCF2 PRKAR2B PFKFB3 PLAUR SERPINB9 REG1A MAPK12 CCL3 CCL4 TIMP1 SPI1 KYNU MAFB BCL2L11 PTPRU SOCS6 CHST3 TRAM2 CD276

Supplementary Table 2: Contd... Pearson Score 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.33 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32

Contd...

IFI30 SPON2 LILRB2 MUC5B HDAC7 TMTC3 ASPHD2 RAET1K CSGALNACT1 PCDHB15 PCDHGA1 SLC18B1 AGAP2 RHOF SLC38A2 MGC16025 TMEM45A KIF26B EPN2 RELT A4GALT KIAA0895 NUP188 CIC ATP8B3 CCDC83 AGRN C10ORF25 STIM2 SYT13 ARRDC2 MYADM LPPR2 LOC152225 MTSS1L SPRED3 SPOCD1 SLC43A3 TTYH2 LOC154761 ALOX5AP AXL BCR BCL2A1 FMNL1 LYST CHRNA7 COL6A1 COL6A2 CTLA4 CYB5R3 EPHA4 FAP FGR

0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31

Contd...

Supplementary Table 2: Contd... Gene Symbol GFI1 HCK HOXC4 KCNN2 ITGB1 ITGAM LYN FURIN FAM78A NFIC NPAS1 PDGFB PIK3C3 PIK3CD REG1B PXN RTN2 PIK3R6 ABCC8 STAT2 LAPTM5 ARHGEF1 SLC16A3 DYSF LMO4 DEGS1 LOC100133050 LILRA6 SEC16A IQCF2 THEMIS2 ZNF516 FAM65A PDCD1LG2 GALNT5 ADAMTS6 ST6GALNAC2 TRIM8 TSPAN14 LILRA5 SLC25A21 C15ORF26 TENM3 RADIL CLEC5A SHANK3 ZNF532 TCP11L2 ELL2 ZNF469 AFAP1-AS1 HAVCR2 ESYT1

Supplementary Table 2: Contd... Pearson Score 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31

Contd...

PLEKHN1 SEC14L2 LRRC8C MPRIP ANKLE2 HHIPL1 TNFAIP8 ATL3 TATDN3 C1ORF162 YPEL4 REEP3 TMPRSS3 PILRA PLEKHG2 SIGLEC14 COQ10A ABCA3 ARHGAP1 BLVRA CAV2 CNP CTSL CSRP2 CD55 FCGR1B FCGR1A FGFR1 FOXD4 GZMA GPR32 RFX8 HOXC13 HK3 HHEX HSPG2 ITGAX ITGA5 LIMS1 LAMB3 TCAF2 MRC1 MAOB MBD1 MGAT1 FAM225A PRRX1 SRGN PLAU RELB RARRES1 KLK6 SLA SLC4A3

0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.31 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3

Contd...

Supplementary Table 2: Contd...

Contd...

LOXL3 MGC2889 SPRYD3 ARHGAP19 ZNF618 OSBPL10 SMG6 ZNF438 KIAA1211 MSANTD3 LRRC25 FAM174B NXPE3 FAM129B MYO1G LOC400043 RAET1L CGB8 PRR29 EHD2 AMZ1

0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3

FSCN1 P value 0.0044 4

2

0

-2

-4

m or N

an

ce

r

al

-6 C

Pearson Score 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3

log2 expression

Supplementary Table 2: Contd... Gene Symbol SECTM1 SRL TJP1 TNFAIP2 ZIC2 WNT10B VIM TYROBP TRPS1 TNFSF9 ADAM19 SGPL1 VNN2 PIAS2 SGMS2 DPF1 BARX2 SCARF1 ELMO1 NUAK1 ARNT2 THRAP3 GFPT2 AHNAK XIRP1 VAPA NUMBL ADAMTS4 CD300C BASP1 PRRC1 SFXN3 NDEL1 SNAI3 MEX3C SLC15A3 DACT1 CHRFAM7A AGPAT4 SPRED1 SH2D1B ADAMTSL4 ITPRIPL2 ELP2 CTHRC1 PGBD3 TUBB6

Supplementary Figure 1: Box and whiskers plot depicting significant upregulation of FSCN1 in CRC patients (n=13) compared to adjacent normal tissue (n=13) based on microarray expression. Data are presented as log2 mRNA expression