Oct 28, 2016 - Outcomes Research, Evidera, Bethesda, Maryland; 2Department of Pediatrics, ... AstraZeneca, Gaithersburg, Maryland; 4Department of Health ...
1287. Caregiver Impact of Respiratory Syncytial Virus Hospitalizations Among United States Preterm Infants 29–35 Weeks’ Gestational Age Robin M. Pokrzywinski, MHA1; Laura L. Swett, PhD1; Jumi Yi, MD2; Veena R. Kumar, MD, MPH3; Kimmie K. McLaurin, MS4; Nancy K. Leidy, PhD5; 1Department of Outcomes Research, Evidera, Bethesda, Maryland; 2Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; 3Department of US Medical Affairs, AstraZeneca, Gaithersburg, Maryland; 4Department of Health Economics and Outcomes Research, AstraZeneca, Gaithersburg, Maryland; 5Department of Scientific Affairs, Evidera, Bethesda, Maryland Session: 139. Clinical Infectious Diseases: Respiratory Infections Friday, October 28, 2016: 12:30 PM Background. Respiratory syncytial virus (RSV) is the leading cause of infant hospitalizations in the United States; however, there is limited understanding of how RSV hospitalizations (RSVH) impact caregivers, particularly of high-risk preterm infants. Methods. SENTINEL1 was an observational study of preterm infants 29–35 weeks’ gestational age hospitalized for confirmed RSV disease during the 2014–2015 RSV season (NCT02273882). Caregiver responses to stress and health measures, including an open-ended question about the impact of the RSVH, were collected at discharge, 1 wk, 2 wks, and 1 mo post discharge. Open-ended responses were grouped by impact theme for analysis. Results. Caregivers provided responses for 198 of 212 enrolled infants with community-acquired RSVH. Caregiver stress and perception of the infant’s stress and health were reported at each timepoint (figure A-B). Emotional impact (e.g. stress, worry, fear), disruption of family routine (e.g. travel for medical visits), medical concerns (e.g. monitoring infant’s breathing), and financial concerns were the most frequently raised issues that persisted up to 1 mo post discharge (table).
continued. Proportion of Responses At Discharge (n = 235) Coordinating Care Miscellaneous Infant Better/Back to Normal No Impact Reported
1 Wk Post Discharge (n = 174)
2 Wks Post Discharge (n = 151)
1 Mo Post Discharge (n = 182)
14 13 5
6 5 15
3 7 31
2 13 19
9
21
26
30
*Caregiver responses could be grouped into multiple impact themes so the percentage at each timepoint will be >100%. More than one caregiver could provide responses for an infant.
Proportion of Responses
Enrolled Infants for Whom Caregivers Responded, n (%) Caregiver Type, % Mother Father Other Impact Theme*, % Emotional Routine Disruption/ Separation from Other Children Medical Concerns Financial Family Relationship Sleep/Energy
At Discharge (n = 235)
1 Wk Post Discharge (n = 174)
2 Wks Post Discharge (n = 151)
1 Mo Post Discharge (n = 182)
183 (86)
152 (72)
133 (63)
154 (73)
75 21 4
80 18 2
79 18 3
78 19 3
54 36
48 25
28 15
33 20
13 30 31 11
5 12 16 11
7 9 4 8
13 12 3 3
Conclusion. Although caregivers reported improvements in stress and health scores, stress-related impacts of the RSVH were high at discharge and remained prevalent up to one mo post discharge. RSVHs have a considerable impact on caregivers that should be included in evaluations of RSV disease burden in preterm infants. This study was sponsored by AstraZeneca. Disclosures. R. M. Pokrzywinski, Evidera: Employee, Salary; L. L. Swett, Evidera: Employee, Salary; V. R. Kumar, AstraZeneca: Employee, Salary and Stock; K. K. McLaurin, AstraZeneca: Employee, employee granted stock and Salary; N. K. Leidy, Evidera: Employee, Salary
Poster Abstracts
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