RESEARCH ARTICLE
Continuous Glucose Monitoring in Patients Undergoing Extracorporeal Ventricular Assist Therapy Antje Gottschalk1☯, Henryk A. Welp2☯*, Laura Leser1, Christian Lanckohr1, Carola Wempe1, Björn Ellger1 1 Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany, 2 Department of Cardiothoracic Surgery, Division of Cardiac Surgery, University Hospital Münster, Münster, Germany ☯ These authors contributed equally to this work. *
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Abstract OPEN ACCESS Citation: Gottschalk A, Welp HA, Leser L, Lanckohr C, Wempe C, Ellger B (2016) Continuous Glucose Monitoring in Patients Undergoing Extracorporeal Ventricular Assist Therapy. PLoS ONE 11(3): e0148778. doi:10.1371/journal.pone.0148778 Editor: Chiara Lazzeri, Azienda OspedalieroUniversitaria Careggi, ITALY Received: August 18, 2015 Accepted: January 22, 2016
Background Dysregulations of blood glucose (BG) are associated with adverse outcome in critical illness; controlling BG to target appears to improve outcome. Since BG-control is challenging in daily intensive care practice BG-control remains poor especially in patients with rapidly fluctuating BG. To improve BG-control and to avoid deleterious hypoglycemia, automated online-measurement tools are advocated. We thus evaluated the point-accuracy of the subcutaneous Sentrino1 Continuous Glucose Monitoring System (CGM, Medtronic Diabetes, Northridge, California) in patients undergoing extracorporeal cardiac life support (ECLS) for cardiogenic shock.
Published: March 10, 2016 Copyright: © 2016 Gottschalk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: Original data are from the Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Germany. They can be obtained from Figshare (DOI: https://dx.doi.org/10.6084/m9.figshare.2076406). Funding: This work was supported from institutional and departmental sources and from Medtronic GmbH, Earl-Bakken-Platz 1, 40670 Meerbusch, Germany. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Methods Management of BG was performed according to institute’s standard aiming at BG-levels between 100–145 mg/dl. CGM-values were recorded without taking measures into therapeutic account. Point-accuracy in comparison to intermittent BG-measurement by the ABLblood-gas analyzer was determined.
Results CGM (n = 25 patients) correlated significantly with ABL-values (r = 0.733, p
