www.ijsrp.org. Correlation of Plasma homocysteine levels with BMI and. Insulin Resistance, amongst Obese, Overweight and Non. Obese Infertile Women.
International Journal of Scientific and Research Publications, Volume 2, Issue 5, May 2012 ISSN 2250-3153
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Correlation of Plasma homocysteine levels with BMI and Insulin Resistance, amongst Obese, Overweight and Non Obese Infertile Women Sachan Rekha*, Patel ML**, Gupta Pooja*, Sachan Pushpalata***, Natu SM****, Pradeep Y* *
Department of Obstetrics & Gynaecology, CSMMU, Lucknow, UP, India ** Department of Medicine, CSMMU, Lucknow, UP, India *** Department of Physiology, CSMMU, Lucknow, UP, India **** Department of Pathology, CSMMU, Lucknow, UP, India
Abstract- Background and Aims: The present study was done to evaluate serum homocysteine level and its correlation with metabolic (S. glucose level, S. insulin level and HOMA-IR.) and anthropometric parameter (BMI) amongst over weight, obese and non obese infertile women. Methods: This cross sectional prospective study was conducted in Department of Obstetrics and Gynaecology, CSM Medical University, Lucknow, UP, India. After informed consent total 90 infertile women were enrolled, which included 29 overweight, 16 obese and 45 non-obese infertile women, who were taken as controls. Blood samples were obtained in morning on 2nd day of menstruation after an overnight fasting. During the same visit all subjects underwent anthropometric measurement. Plasma homocysteine concentration was measured by fluorescence polarization immunoassay by using ABBOTT diagnostic kit (USA). The estimation of insulin resistance by HOMA-IR score, and BMI was calculated. Results: Difference between the BMI, homocysteine levels, insulin and HOMA-IR of three groups were statistically significant (p
