Articles in PresS. Am J Physiol Heart Circ Physiol (August 1, 2008). doi:10.1152/ajpheart.00532.2008
Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload
Nadia Hedhli, Paulo Lizano, Chull Hong, Luke F. Fritzky, #Sunil K. Dhar, Huasheng Liu, Yimin Tian, Shumin Gao, *Kiran Madura, Stephen F. Vatner, Christophe Depre
Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, UMDNJ, Newark, NJ. #
Department of Mathematical Sciences, New Jersey Institute of Technology (NJIT), Newark, NJ.
* Department of Biochemistry, Robert Wood Johnson Medical School, UMDNJ, Piscataway, NJ.
Corresponding author contact information: Christophe Depre, MD, PhD Cardiovascular Research Institute Department of Cell Biology and Molecular Medicine University of Medicine and Dentistry of New Jersey New Jersey Medical School 185 South Orange Street, MSB G-609 Newark, NJ 07103 Phone: (973) 972-3926 Fax: (973) 972-7489
[email protected]
Short title: Proteasome inhibition and cardiac hypertrophy
Copyright © 2008 by the American Physiological Society.
2 ABSTRACT We tested the possibility that proteasome inhibition may reverse pre-existing cardiac hypertrophy and improve remodeling upon pressure overload. Mice were submitted to aortic banding, and followed up for three weeks. The proteasome inhibitor epoxomicin (0.5 mg/kg) or the vehicle were injected daily, starting two weeks after banding. At the end of the third week, vehicle-treated banded animals showed significant (P
