1989-1993 B.S. in Biology, University of Science and Technology of China.
Research Experience. 2008-present Associate Professor at the University of
California, Berkeley .... 30, Chen, L., Tracy, T., and Nam, C.I. (2007). Dynamics of
...
Curriculum Vitae Lu Chen Address
University of California, Berkeley Department of Molecular and Cell Biology 201A Life Sciences Addition Berkeley, CA 94720-3200
Telephone
(510) 643-8163 – office
(510) 643-8164 – lab Email
[email protected]
Education 1993-1998 1989-1993
Ph.D. in Neuroscience, University of Southern California B.S. in Biology, University of Science and Technology of China
Research Experience 2008-present Associate Professor at the University of California, Berkeley 2003- 2008 Assistant Professor at the University of California, Berkeley 1999-2002 Postdoctoral Fellow with Dr. Roger Nicoll, UCSF 1998-1999 Postdoctoral Fellow with Dr. Richard Thompson, USC 1993-1998 Ph.D. student with Dr. Richard Thompson, USC 1996 Marine Biological Laboratory summer course (Neural System and Behavior), Woods Hole, MA Teaching 2005- present First year graduate student advisor, HWNI and Dept. MCB, UC Berkeley 2005-present Instructor, Introduction to Neurobiology Lab (upper division undergraduate level), UC Berkeley 2003-present Instructor, Advanced Cellular Neurobiology (graduate level), UC Berkeley 2003-present Instructor, Introduction to Neurobiology (upper division undergraduate level), UC Berkeley 1993-1997 Teaching assistant, Dept. Biological Sciences, USC Awards and Services 2009-present Society for Neuroscience Program Committee 2008-present Associate Editor, Journal of Neuroscience 2008 Ad hoc member, SYN1 Study Section 2005 MacArthur Fellowship 2005 W. M. Keck Foundation Distinguished Young Scholar in Medical Research 2005 NARSAD Young Investigator Award 2004 David and Lucile Packard Fellow in Science and Engineering 2004 Mary Elizabeth Rennie Endowment Epilepsy Fund 2003 Beckman Young Investigator Award 2001 National Research Service Award Postdoctoral Fellowship
Peer-reviewed Research Articles 1, Chen, C., Kano, M., Abeliovich, A., Chen, L., Bao, S., Kim, J. J., Hashimoto, K., Thompson, R. F., and Tonegawa, S. (1995). Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKCγ mutant mice. Cell, 83, 1233-1242. 2, Chen, L., Bao, S., Kim, J. J., Lockard, J., and Thompson, R. F. (1996). Impaired classical eyeblink conditioning in cerebellar lesion and Purkinje cell degeneration mutant mice. Journal of Neuroscience, 16, 2829-2838. 3, Shibuki, K., Gomi, H., Chen, L., Bao, S., Kim, J. J., Wakatsuki, H., Fujisaki, T., Fujimoto, K., Ikeda, T., Chen, C., Thompson, R. F., and Itohara, S. (1996) Deficient cerebellar long-term depression, impaired eyeblink conditioning and normal motor coordination in GFAP mutant mice. Neuron, 16, 587-599. 4, Kim, J. J., Shih, J. C., Chen, K., Chen, L., Bao, S., Maren, S., Anagnostaras, S. G., Fanselow, M. S., Maeyer, E. D., Seif, I., and Thompson, R. F. (1997). Selective enhancement of emotional, but not motor learning in monoamine oxidase A-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 94, 5929-5933. 5, Bao, S., Chen, L., and Thompson, R. F. (1998). Classical eyeblink conditioning in two strains of mice: conditioned responses, sensitization and spontaneous eyeblinks. Behavioral Neuroscience, 112, 714-718. 6, Qiao, X., Chen, L., Gao, H., Bao, S, Hefti, H., Thompson, R. F., and Knusel, B. (1998). Cerebellar brain-derived neurotrophic factor-TrkB defect associated with impairment of eyeblink conditioning in stargazer mutant mice. Journal of Neuroscience, 18, 6990-6999. 7, Bao, S., Chen, L., Qiao, X., and Thompson, R. F. (1998). Impaired classical eyeblink conditioning in waggler, a mutant mouse with localized BDNF deficit in the cerebellum. Learning and Memory, 5, 355-364. 8, Chen, L., Bao, S., and Thompson R. F. (1999). Bilateral lesions of the interpositus nucleus completely prevent eyeblink conditioning in Purkinje cell degeneration mutant mice. Behavioral Neuroscience, 113, 204-210. 9, Chen, L., Bao, S., Qiao, X., and Thompson, R. F. (1999). Impaired cerebellar synapse maturation in waggler, a mutant mouse with a disrupted neuronal calcium channel gamma subunit. Proceedings of the National Academy of Sciences of the United States of America, 96, 12132-12137. 10, Bao, S., Chen, L., Qiao, X., and Thompson, R. F. (1999). Transgenic brain-derived neurotrophic factor modulates a developing cerebellar inhibitory synapse. Learning & Memory, 6, 276-283. 11, Bao, S., Chen, L., and Thompson, R. F. (2000). Learning- and cerebellum-dependent neuronal activity in the lateral pontine nucleus. Behavioral Neuroscience, 114, 254-61.
12, Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N., Kawaski, Y., Wenthold R. J., Bredt, D. S., and Nicoll, R. A. (2000). Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature, 408, 936-943. 13, Bao, S., Chen, L., Kim, J. J. and Thompson, R. F. (2002). Cerebellar cortical inhibition and classical eyeblink conditioning. Proceedings of the National Academy of Sciences of the United States of America, 99, 1592-97. 14, Chetkovich, D. M*., Chen, L.*, Stocker, T. J., Nicoll, R.A., and Bredt, D. S. (2002). Phosphorylation of the PDZ Binding Site of Stargazin Regulates Binding to PSD-95 and Synaptic Targeting of AMPA Receptors. Journal of Neuroscience, 22, 5791-6. (*, equal contribution) 15, Schnell, E., Sizemore, M., Karimzadegan, S., Chen, L., Bredt, D. S., and Nicoll, R. A. (2002). Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proceedings of the National Academy of Sciences of the United States of America, 99, 13902-7. 16, Tomita, S., Chen, L., Kawasaki, Y., Petralia, R. S., Wenthold, R. J., Nicoll, R. A., and Bredt, D. S. (2003). Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. Journal of Cell Biology, 161, 805-816. 17, Chen, L., El-Husseini, A., Tomita, A., Bredt, D. S., and Nicoll, R. A. (2003). Stargazin differentially controls the trafficking of AMPA and kainate receptors. Molecular Pharmacology, 64, 703-706. 18, Nam, C. I. and Chen, L. (2005). Postsynaptic Assembly Induced by Presynaptic Neurexin and Neurotransmitter. Proceedings of the National Academy of Sciences of the United States of America, 102, 6137-42. 19, Aoto, J., Ting, P., Maghsoodi, B., Xu, N., Henkemeyer, M. and Chen, L. (2007). Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation. Journal of Neuroscience, 27, 7508-19. 20, Aoto J., Maghsoodi, B., Nam, C.I., Poon, M., Ting, P. and Chen, L. Aoto, J., Nam, C.I., Poon, M., Ting, P. and Chen, L. (2008). Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity. Neuron, 60, 308-320. 21, Maghsoodi, B., Poon, M., Nam, C.I., Aoto J., Ting, P. and Chen, L. (2008). Retinoic acid regulates RARα-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America, 105, 16015-20. 22, Poon, M. and Chen, L. (2008). Retinoic acid-gated sequence-dependent translational control by RARα. Proceedings of the National Academy of Sciences of the United States of America, 105, 20303-20308. 23, Little, D. and Chen, L. (2009). Identification of coevolving residues and coevolution potentials emphasizing structure, bond formation and catalytic coordination in protein evolution. PLoS ONE 4(3): e4762. doi:10.1371/journal.pone.0004762.
24, Soden, M. and Chen, L. (2010) Fragile-X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid (revised manuscript under review by Neuron). Review Articles 25, Thompson, R. F., Bao, S., Chen, L., Cipriano, B., Grethe, J. S., Kim, J. J., Thompson, J. K., Tracy, J., Weninger, M. S., and Krupa, D. J. (1996). Associative learning. In: The Cerebellum and Cognition. 151-189. (Eds. J. D. Schmahmann), Academic Press, New York. 26, Kim, J. J., Chen, L., Bao, S., Sun, W., and Thompson, R. F. (1996). Genetic dissection of the cerebellar circuitry involved in classical eyeblink conditioning. In: Gene Targeting and New Development in Neurobiology, 3-15. (Eds. S. Nakanishi et al.), Japan Scientific Societies Press, Tokyo. 27, Bao, S. and Chen., L (2002). Genetic substrates of memory: cerebellum [.In Encyclopedia of Learning and Memory, 2nd edition (Ed. Byrne, J. H.). MacMillan Publishers, Farmington Hills]. 28, Chen, L., and Maghsoodi, B., (2006). Synaptic trafficking of AMPA receptors. [.In Protein Trafficking in the Neuron (Ed. Bean, A. J.). Elsevier Academic Press, Oxford, UK]. 29, Aoto, J. and Chen, L. (2007). Bidirectional ephrin/Eph signaling in synaptic function. Brain Research Reviews 1184, 72-80. 30, Chen, L., Tracy, T., and Nam, C.I. (2007). Dynamics of postsynaptic glutamate receptor targeting. Current Opinion in Neurobiology 17 (1), 53-58. 31, Hastie, P. and Chen, L. (2007). Synaptic trapping of AMPA receptors. Cell Science Reviews.
