Cystectomy with adjuvant radiotherapy for invasive

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presented at: Cystectomy with adjuvant radiotherapy ... All patients underwent radical cystectomy and ... Urinary toxicity is scored if a neobladder is present.
Cystectomy with adjuvant radiotherapy for invasive bladder tumors: early results of a phase II study Swimberghe, M.1, Rammant, E.1, Decaestecker, K.2 , Ost, P.1, Junius, S.3, Dirix, P.4, De Meerleer, G.5, Fonteyne, V.1 1

Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium, 2 Department of Urology, Ghent University Hospital, Belgium, 3 Department of Radiotherapy, CH Mouscron, Mouscron, Belgium, 4 Department of Radiotherapy, GZA St-Augustinus Hospital, Antwerp, Belgium, 5 Department of Radiotherapy, University Hospitals Leuven, Leuven, Belgium

Study purpose Study purpose is to evaluate toxicity during and after adjuvant radiotherapy in patients who underwent radical cystectomy for high risk invasive bladder cancer. Secondary end points are local and distant control and disease-specific and overall survival.

Introduction and objectives Patients with locally advanced muscle invasive bladder cancer (MIBC) have a high risk of recurrence. Studies have shown a benefit on locoregional control of postoperative radiotherapy (PORT) after radical cystectomy, but its use remains limited due to fear of severe toxicity. With modern radiotherapy (RT) the place of PORT should be reassessed.

Materials and methods A phase II study was started to evaluate acute toxicity of PORT with modern RT. All patients underwent radical cystectomy and presented one or more of the following pathological findings: pT3 with lymphovascular invasion, pT4,