Decreased excretion of urine glycosaminoglycans as marker in renal ...

4 downloads 0 Views 173KB Size Report
Key words: AA amyloidosis; AL amyloidosis; glomer-constituents of proteoglycans which usually contain ular disease; glycosaminoglycans one or more GAG ...
Nephrol Dial Transplant ( 1997) 12: 1161–1166

Nephrology Dialysis Transplantation

Original Article

Decreased excretion of urine glycosaminoglycans as marker in renal amyloidosis Jan Tencer1, Ole Torvit2, Anders Grubb3, Sven Bjo¨rnsson4, Hans Thysell1 and Bengt Rippe1 1Department of Nephrology, 2Division of Diabetology and Endocrinology, 3Department of Clinical Chemistry, 4Division of Clinical Chemistry, Lund University Hospital, S-221 85 Lund; Va¨xjo¨ Central Hospital, S-351 85 Va¨xjo¨, Sweden

Abstract Background. The diagnosis of renal amyloidosis is normally established by kidney biopsy. In order to advance the determination of the diagnosis and the initiation of the therapy, fast and cheap, non-invasive diagnostic techniques are required. Methods. Urine excretion of glycosaminoglycans (GAG) was measured in 10 patients with AA amyloidosis and 5 patients with AL amyloidosis and compared to 25 controls with primary glomerular diseases and 22 healthy controls. The subjects with primary glomerular disease were matched with regard to their renal function and the degree of albuminuria. Results. The median urine GAG to creatinine ratio and the median fractional GAG excretion were significantly decreased (P